Výsledky vyhledávání - "A. M. DiBisceglie"

Data from Mutations in the Hepatitis C Virus core Gene Are Associated with Advanced Liver Disease and Hepatocellular Carcinoma

Autor: Andrea D. Branch, Gary Benson, Suresh M. Desai, Adrian M. DiBisceglie, Xiaofeng Fan, Cinzia Balestrieri, Stephanie H. Factor, Sarah L. Fishman

Purpose: Hepatitis C virus (HCV) infection can promote the development of hepatocellular carcinoma (HCC). Published data implicate the HCV core gene in oncogenesis. We tested the hypothesis that core gene sequences from HCC patients differ from those

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3736ad0c7e55fff55094a2f1e3c7e687
https://doi.org/10.1158/1078-0432.c.6517801.v1

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Mephenytoin disposition and serum bile acids as indices of hepatic function in chronic viral hepatitis*

Autor: Patricia A. Arns, Jeanne G. Waggoner, Grant R. Wilkinson, Robert A. Branch, Jay H. Hoofnagle, Adedayo Adedoyin, Adrian M. DiBisceglie

Publikováno v: Clinical Pharmacology & Therapeutics. 62:527-537

Background and objectives The effect of chronic viral hepatitis on liver function may vary from none to hepatic failure. Changes in function are usually the result of impaired hepatocyte function or altered vascular flow and architecture. Conventiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658f78a40091ba15c9e7c428fb2bb8ce
https://doi.org/10.1016/s0009-9236(97)90048-5

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Assessment of monoethylglycinexylidide as measure of liver function for patients with chronic viral hepatitis

Autor: Adrian M. DiBisceglie, Michael W. Fried, Maureen Sampson, David E. Kleiner, Mark E. Ruddel, Ronald J. Elin

Publikováno v: Clinical Chemistry. 43:1952-1957

The liver metabolizes lidocaine by oxidative deethylation to form monoethylglycinexylidide (MEGX), an analyte proposed as an index of liver function. We determined MEGX and lidocaine serum concentrations with the TDx (Abbott Laboratories) at baseline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60a8e46647570bce576d35387264e4bd
https://doi.org/10.1093/clinchem/43.10.1952

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Mutations in the Hepatitis C Virus Core Gene Are Associated with Advanced Liver Disease and Hepatocellular Carcinoma

Autor: Sarah L. Fishman, Stephanie H. Factor, Cinzia Balestrieri, Xiaofeng Fan, Adrian M. DiBisceglie, Suresh M. Desai, Gary Benson, Andrea D. Branch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cbd4c22bce1813ac07d555ba21cf1e
https://europepmc.org/articles/PMC3142862/

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Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B

Autor: Yun Fan Liaw, W. Bao, Jens Rasenack, Thierry Poynard, Stefan Zeuzem, Jinlin Hou, Maria Buti, Tuan T. Nguyen, Edward Gane, Anuchit Chutaputti, Adrian M. DiBisceglie, Seng Gee Lim, Bruce Belanger, Christopher B. O'Brien, Jidong Jia, Nikolai V. Naoumov

Publikováno v: Journal of hepatology. 51(1)

Background/Aims In the GLOBE trial, telbivudine treatment was identified as a significant, independent predictor of better outcomes at 2years. We analyzed all telbivudine recipients in this trial to determine the predictors of optimal outcomes. Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3e12794a4c0f807c94d9ea9f0b9290
https://pubmed.ncbi.nlm.nih.gov/19443071

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Quasispecies heterogeneity within the E1/E2 region as a pretreatment variable during pegylated interferon therapy of chronic hepatitis C virus infection

Autor: Edgardo Hembrador, Thomas J. Chambers, Xiaofeng Fan, Lynn B. Dustin, Adrian M. DiBisceglie, Deborah A. Droll, Michael Nickells, Tiffany Slater

Publikováno v: Journal of virology. 79(5)

A series of 29 patients undergoing treatment for chronic hepatitis C virus (HCV) genotype 1 infection with pegylated alpha-2a interferon plus ribavirin were studied for patterns of response to antiviral therapy and viral quasispecies evolution. All p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d2b8736f734f252b83c2801ddb9003
https://pubmed.ncbi.nlm.nih.gov/15709027

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Assessment of monoethylglycinexylidide as measure of liver function for patients with chronic viral hepatitis

Autor: R J, Elin, M W, Fried, M, Sampson, M, Ruddel, D E, Kleiner, A M, DiBisceglie

Publikováno v: Clinical chemistry. 43(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b97b3a229d2e148c1756a88bd4c84d96
https://pubmed.ncbi.nlm.nih.gov/9342018

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An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico

Autor: V. M.G. DeBenedetti, S. C. Chia, Judith A. Welsh, William P. Bennett, N. V. Bergasa, H. Cawley, Ylermi Soini, John D. Groopman, L. E. Munoz Espinosa, A. M. DiBisceglie, C. Hansen, E. A. Jones, Catherine Sandoval, I. E. Calderon, Curtis C. Harris, Jia-Sheng Wang, G. E. Trivers

Publikováno v: Carcinogenesis. 17(5)

The p53 tumor suppressor gene is commonly mutated in human hepatocellular carcinoma (HCC). The most frequent mutation in HCC in populations exposed to a high dietary intake of aflatoxin B1 (AFB1) is an AGGarg-->AGTser missense mutation in codon 249 o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f022db5b18ae5397309b3856dfa4bfaf
https://pubmed.ncbi.nlm.nih.gov/8640905

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Hepatitis C Viral RNA and Hepatic Cytokine Expression in Chronic Hepatitis C: Effects of Alpha Interferon Therapy

Autor: Jay H. Hoofnagle, Adrian M. DiBisceglie, Michiko Shindo

Publikováno v: Viral Hepatitis and Liver Disease ISBN: 9784431682578

We investigated the changes in serum and hepatic hepatitis C virus (HCV)-RNA levels and in hepatic cytokine expression in seven patients with chronic hepatitis C treated with recombinant alpha interferon (rIFNα). Titers of HCV-RNA in serum decreased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b434ac353735d6841dc7e5fa65cf77e
https://doi.org/10.1007/978-4-431-68255-4_164

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