Zobrazeno 1 - 10
of 1 362
pro vyhledávání: '"A. M. Deane"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundT cells form one of the key pillars of adaptive immunity. Using their surface bound T cell antigen receptors (TCRs), these cells screen millions of antigens presented by major histocompatibility complex (MHC) or MHC-like molecules. In other
Externí odkaz:
https://doaj.org/article/2331d3c5d2894b149ead1b291cba1917
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Antibodies are a popular and powerful class of therapeutic due to their ability to exhibit high affinity and specificity to target proteins. However, the majority of antibody therapeutics are not genetically human, with initial therapeutic designs ty
Externí odkaz:
https://doaj.org/article/6406647f7b7649089c8989c43f5d8b0c
Autor:
Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Engineered antibody formats, such as antibody fragments and bispecifics, have the potential to offer improved therapeutic efficacy compared to traditional full-length monoclonal antibodies (mAbs). However, the translation of these non-natural molecul
Externí odkaz:
https://doaj.org/article/902ae4a0e4394deeb9b5cd245a0a3c88
Autor:
Abraham H. Hulst, Connie P. C. Ow, Clive N. May, Sally H. Hood, Mark P. Plummer, Jeroen Hermanides, Daniël H. van Raalte, Adam M. Deane, Rinaldo Bellomo, Yugeesh R. Lankadeva
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background People with type 2 diabetes mellitus treated with sodium-glucose transporter-2 inhibitors (SGLT2i) have lower rates of acute kidney injury (AKI). Sepsis is responsible for the majority of AKI in critically ill patients. This study
Externí odkaz:
https://doaj.org/article/fb3379f34b1d4f398e64131e44166cb9
Publikováno v:
CHEST Critical Care, Vol 2, Iss 3, Pp 100090- (2024)
Externí odkaz:
https://doaj.org/article/c9661ec8235149079b7e11a128b9e6e5
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Protein-ligand binding site prediction is a useful tool for understanding the functional behaviour and potential drug-target interactions of a novel protein of interest. However, most binding site prediction methods are tested by providing c
Externí odkaz:
https://doaj.org/article/20826a9cc211447c9e2924fdbcfa2204
Autor:
Eve Richardson, Sagida Bibi, Florence McLean, Lisa Schimanski, Pramila Rijal, Marie Ghraichy, Valentin von Niederhäusern, Johannes Trück, Elizabeth A. Clutterbuck, Daniel O’Connor, Kerstin Luhn, Alain Townsend, Bjoern Peters, Andrew J. Pollard, Charlotte M. Deane, Dominic F. Kelly
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Outbreaks of Ebolaviruses, such as Sudanvirus (SUDV) in Uganda in 2022, demonstrate that species other than the Zaire ebolavirus (EBOV), which is currently the sole virus represented in current licensed vaccines, remain a major threat to global healt
Externí odkaz:
https://doaj.org/article/245451aecafd4d5884059c3f71712a1a
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
To be viable therapeutics, antibodies must be tolerated by the human immune system. Rational approaches to reduce the risk of unwanted immunogenicity involve maximizing the ‘humanness’ of the candidate drug. However, despite the emergence of new
Externí odkaz:
https://doaj.org/article/0db197a996f4445f862a7fd69ab23712
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Antibodies with lambda light chains (λ-antibodies) are generally considered to be less developable than those with kappa light chains (κ-antibodies). Though this hypothesis has not been formally established, it has led to substantial syste
Externí odkaz:
https://doaj.org/article/3aa009e08b094dc2937b78da4414d5a3
Autor:
Daniel E. Leisman, Damian R. Handisides, Lakhmir S. Chawla, Timothy E. Albertson, Laurence W. Busse, David W. Boldt, Adam M. Deane, Michelle N. Gong, Kealy R. Ham, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, B. Taylor Thompson, James S. Tumlin, Christopher D. Adams, Tony N. Hodges, Rinaldo Bellomo
Publikováno v:
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Background The physiological effects of renin-angiotensin system modulation in acute respiratory distress syndrome (ARDS) remain controversial and have not been investigated in randomized trials. We sought to determine whether angiotensin-II
Externí odkaz:
https://doaj.org/article/d3e87ce500d34c3794fd0a6b208b4a32