Zobrazeno 1 - 10
of 652
pro vyhledávání: '"A. M. De Marzo"'
Autor:
Mindy K. Graham, Rulin Wang, Roshan Chikarmane, Bulouere Abel, Ajay Vaghasia, Anuj Gupta, Qizhi Zheng, Jessica Hicks, Polina Sysa-Shah, Xin Pan, Nicole Castagna, Jianyong Liu, Jennifer Meyers, Alyza Skaist, Yan Zhang, Michael Rubenstein, Kornel Schuebel, Brian W. Simons, Charles J. Bieberich, William G. Nelson, Shawn E. Lupold, Theodore L. DeWeese, Angelo M. De Marzo, Srinivasan Yegnasubramanian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract How prostate cancer cells and their precursors mediate changes in the tumor microenvironment (TME) to drive prostate cancer progression is unclear, in part due to the inability to longitudinally study the disease evolution in human tissues.
Externí odkaz:
https://doaj.org/article/e570ed028e564316b359132fbf5d96e9
Autor:
Mark C. Markowski, Mary-Ellen Taplin, Rahul Aggarwal, Laura A. Sena, Hao Wang, Hanfei Qi, Aliya Lalji, Victoria Sinibaldi, Michael A. Carducci, Channing J. Paller, Catherine H. Marshall, Mario A. Eisenberger, David E. Sanin, Srinivasan Yegnasubramanian, Carolina Gomes-Alexandre, Busra Ozbek, Tracy Jones, Angelo M. De Marzo, Samuel R. Denmeade, Emmanuel S. Antonarakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cyclic high-dose testosterone administration, known as bipolar androgen therapy (BAT), is a treatment strategy for patients with metastatic castration-resistant prostate cancer (mCRPC). Here, we report the results of a multicenter, single ar
Externí odkaz:
https://doaj.org/article/48b46172ca5a4aa0833d3da4c8f53c4c
Autor:
Hannah E. Bergom, Laura A. Sena, Abderrahman Day, Benjamin Miller, Carly D. Miller, John R. Lozada, Nicholas Zorko, Jinhua Wang, Eugene Shenderov, Francisco Pereira Lobo, Fernanda Caramella-Pereira, Luigi Marchionni, Charles G. Drake, Tamara Lotan, Angelo M. De Marzo, Justin Hwang, Emmanuel S. Antonarakis
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-9 (2024)
Abstract Patients with prostate cancer (PC) generally do not respond favorably to immune checkpoint inhibitors, which may be due to a low abundance of tumor-infiltrating lymphocytes even when mutational load is high. Here, we identified a patient who
Externí odkaz:
https://doaj.org/article/a63fc47e643a46939677c01b1b4e10df
Autor:
Joakin O. Mori, Elizabeth A. Platz, Jiayun Lu, Alexandria Brame, Misop Han, Corinne E. Joshu, Angelo M. De Marzo, Alan K. Meeker, Christopher M. Heaphy
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundTelomeres are located at chromosomal termini and function to maintain genomic integrity. Telomere dysfunction is a well-recognized contributor to aging and age-related diseases, such as prostate cancer. Since telomere length is highly herit
Externí odkaz:
https://doaj.org/article/320c4606921c4c48b2696c1f46557873
Autor:
Christopher M Heaphy, Corinne E Joshu, John R Barber, Christine Davis, Jiayun Lu, Reza Zarinshenas, Edward Giovannucci, Lorelei A Mucci, Meir J Stampfer, Misop Han, Angelo M De Marzo, Tamara L Lotan, Elizabeth A Platz, Alan K Meeker
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 5, Pp 481-491 (2022)
Abstract Current biomarkers are inadequate prognostic predictors in localized prostate cancer making treatment decision‐making challenging. Previously, we observed that the combination of more variable telomere length among prostate cancer cells an
Externí odkaz:
https://doaj.org/article/d83e9cf0b5244fd6a2439370f8fc6cb4
Autor:
Mark C. Markowski, Hao Wang, Angelo M. De Marzo, Michael T. Schweizer, Emmanuel S. Antonarakis, Samuel R. Denmeade
Publikováno v:
European Urology Open Science, Vol 41, Iss , Pp 112-115 (2022)
Bipolar androgen therapy (BAT) relies on oscillating levels of serum testosterone as a way to treat patients with metastatic castration-resistant prostate cancer (mCRPC). Aggressive-variant prostate cancers typically require combination chemotherapy
Externí odkaz:
https://doaj.org/article/4bc2a24fd1db4ec6b43aeedc41d28c67
Autor:
Laura A. Sena, Rajendra Kumar, David E. Sanin, Elizabeth A. Thompson, D. Marc Rosen, Susan L. Dalrymple, Lizamma Antony, Yuhan Yang, Carolina Gomes-Alexandre, Jessica L. Hicks, Tracy Jones, Kiara A. Bowers, Jillian N. Eskra, Jennifer Meyers, Anuj Gupta, Alyza Skaist, Srinivasan Yegnasubramanian, Jun Luo, W. Nathaniel Brennen, Sushant K. Kachhap, Emmanuel S. Antonarakis, Angelo M. De Marzo, John T. Isaacs, Mark C. Markowski, Samuel R. Denmeade
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have previously demonstrated that the cyclical administration of supraphysiological androgen (SPA),
Externí odkaz:
https://doaj.org/article/1190b8e3606d4217ab6c491c95462033
Autor:
Tesa M. Severson, Yanyun Zhu, Angelo M. De Marzo, Tracy Jones, Jonathan W. Simons, William G. Nelson, Srinivasan Yegnasubramanian, Matthew L. Freedman, Lodewyk Wessels, Andries M. Bergman, Michael C. Haffner, Wilbert Zwart
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1942-1955 (2021)
The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors d
Externí odkaz:
https://doaj.org/article/56b5db94e7bb424f9f026fc02defd139
Autor:
Lauren B. Peiffer, Jessica Hicks, Rebecca Y. Sosa, Angelo M. De Marzo, Karen S. Sfanos, Janielle P. Maynard
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The 5-year survival rate for patients diagnosed with distant metastatic prostate cancer in the United States is 30.6%. Therefore, there is a great need to develop in vivo model systems to study prostate cancer metastasis and to test potential therape
Externí odkaz:
https://doaj.org/article/d5fb3d77abd240289fd047095a2786a4
Autor:
William G. Nelson, Otis W. Brawley, William B. Isaacs, Elizabeth A. Platz, Srinivasan Yegnasubramanian, Karen S. Sfanos, Tamara L. Lotan, Angelo M. De Marzo
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Prostate cancer exerts a greater toll on African American men than on White men of European descent (hereafter referred to as European American men): the disparity in incidence and mortality is greater than that of any other common cancer. The dispro
Externí odkaz:
https://doaj.org/article/efe4325533a14b22bf895c05a7fb49fa