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Akademický článek

Cubic crystal elastic constants of a white dwarf stellar core determined via modal analysis

Autor: K. A. Pestka II, A. M. Crews, R. C. Highley, L. K. Deale

Publikováno v: AIP Advances, Vol 11, Iss 10, Pp 105111-105111-7 (2021)

In this work, we present the cubic crystal elastic constants of a fully crystallized white dwarf stellar core. Elastic constants were calculated utilizing modal analysis of three-dimensional single-layer and stratified multi-layer crystalline core mo

Externí odkaz: https://doaj.org/article/bbca3c423c5d4e00aee6caa8777b05f2

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Akademický článek

Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

Autor: Lucas D Sanor, Grant Parker Flowers, Craig M Crews

Publikováno v: eLife, Vol 9 (2020)

Axolotls and other salamanders can regenerate entire limbs after amputation as adults, and much recent effort has sought to identify the molecular programs controlling this process. While targeted mutagenesis approaches like CRISPR/Cas9 now permit ge

Externí odkaz: https://doaj.org/article/6cb4be7d445d43168d6e9b16052a967f

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Akademický článek

Enrollee Characteristics in an Intensive Tobacco Dependence Treatment Program: The Relationship of Race and Sex to Demographic Factors and Tobacco Use Patterns

Autor: Thomas J. Payne, Christine E. Sheffer, Natalie W. Gaughf, Monica J. Sutton, Holly H. Peeples, Okan U. Elci, Jennie Z. Ma, Alan Penman, Karen M. Crews

Publikováno v: Frontiers in Psychiatry, Vol 10 (2019)

Intensive tobacco treatment programs offer many advantages relative to other treatment options, particularly for more complex patients, e.g., highly nicotine dependent, or those with medical and psychiatric symptoms and disorders. Efforts to better u

Externí odkaz: https://doaj.org/article/5eb1c6c18cc149f495843ce33989d598

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Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC

Autor: Jake C. Swartzel, Michael J. Bond, Andreas P. Pintado-Urbanc, Mehana Daftary, Mackenzie W. Krone, Todd Douglas, Evan J. Carder, Joshua T. Zimmer, Takahiro Maeda, Matthew D. Simon, Craig M. Crews

Publikováno v: ACS Chemical Biology. 17:1789-1798

The RNA decapping scavenger protein, DcpS, has recently been identified as a dependency in acute myeloid leukemia (AML). The potent DcpS inhibitor RG3039 attenuates AML cell viability, and shRNA knockdown of DcpS is also antiproliferative. Importantl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dbc1f4df166eac81299905db0dd4b9
https://doi.org/10.1021/acschembio.2c00145

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PROTACs: past, present and future

Autor: Ke Li, Craig M. Crews

Publikováno v: Chem Soc Rev

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules consisting of one ligand that binds to a protein of interest (POI) and another that can recruit an E3 ubiquitin ligase. The chemically-induced proximity between the POI and E3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e834e80f1723a742681dc5f95265f2
https://doi.org/10.1039/d2cs00193d

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Data from MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

Autor: Craig M. Crews, Yimin Qian, Hanqing Dong, Schan Lartigue, John Hines

Although the number of proteins effectively targeted for posttranslational degradation by PROTAC has grown steadily, the number of E3 ligases successfully exploited to accomplish this has been limited to the few for which small-molecule ligands have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f2c02c2f038f549b633d22cb8b0251
https://doi.org/10.1158/0008-5472.c.6510722.v1

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Supplementary Data from Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation

Autor: Craig M. Crews, Brian J. Druker, Samantha L. Savage Stevens, Christopher A. Eide, Daniel P. Bondeson, Anna Reister Schultz, George M. Burslem

Supplemental Figures and Tables. Figure S1 - Immunoblotting characterization of GMB-101 and GMB-475. Figure S2 - Validation of degradation and compound toxicity via comparison of GMB-475 and GMB-651. Figure S3 - Combinations of ATP competitive TKIs w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c16edb5114867b4d870998a6ddd8d8
https://doi.org/10.1158/0008-5472.22421222

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Supplementary Data from MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

Autor: Craig M. Crews, Yimin Qian, Hanqing Dong, Schan Lartigue, John Hines

Figure S1 shows that treatment of cultured cells (HCT116) with the dual mode of action PROTAC A1874 results in an antiproliferative effect that is equally potent and more effective than a combination treatment with both component ligands (JQ1 and ida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a368466326f379202d8cd1450561662
https://doi.org/10.1158/0008-5472.22420688.v1

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