Výsledky vyhledávání - "A. M. Chudzinski-Tavassi"

Akademický článek

Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity

Autor: K. L. P. Morais, L. Ciccone, E. Stura, M. P. Alvarez-Flores, G. Mourier, M. Vanden Driessche, J. M. Sciani, A. Iqbal, S. P. Kalil, G. J. Pereira, R. Marques-Porto, P. Cunegundes, L. Juliano, D. Servent, A. M. Chudzinski-Tavassi

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Amblyomin-X is a Kunitz-type FXa inhibitor identified through the transcriptome analysis of the salivary gland from Amblyomma sculptum tick. This protein consists of two domains of equivalent size, triggers apoptosis in different tumor cell lines, an

Externí odkaz: https://doaj.org/article/1dda03cd9dbb4ede84e2fbe8555f9a69

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Akademický článek

rACLF, a recombinant snake venom metalloprotease, activates endothelial cells in vitro

Autor: C. K. De Moraes, M. Fritzen, A. M. Chudzinski-Tavassi, H. S. Selistre-de-Araújo

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 14, Iss 1, Pp 113-127 (2008)

Snake venom metalloproteases (SVMPs) comprise a family of snake venom toxins responsible for most of local and systemic effects observed during envenomation by snakes from the Viperidae family. The vascular system and more specifically the endotheliu

Externí odkaz: https://doaj.org/article/ca80bbba3e974683a572c5fb1efcbf91

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Akademický článek

Biochemical and biological properties of Lonomia obliqua bristle extract

Autor: A. M. Chudzinski-Tavassi, L. C. Carrijo-Carvalho

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 2, Pp 159-171 (2006)

Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the mai

Externí odkaz: https://doaj.org/article/0477e1256f7d474a8847b563230bc453

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A Kunitz-type inhibitor from tick salivary glands: A promising novel antitumor drug candidate

Autor: Aline R. M. Lobba, Miryam Paola Alvarez-Flores, Melissa Regina Fessel, Marcus Vinicius Buri, Douglas S. Oliveira, Renata N. Gomes, Priscila S. Cunegundes, Carlos DeOcesano-Pereira, Victor D. Cinel, Ana M. Chudzinski-Tavassi

Publikováno v: Frontiers in molecular biosciences. 9

Salivary glands are vital structures responsible for successful tick feeding. The saliva of ticks contains numerous active molecules that participate in several physiological processes. A Kunitz-type factor Xa (FXa) inhibitor, similar to the tissue f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc061e0986ec9326dac6a121818f6a64
https://pubmed.ncbi.nlm.nih.gov/36052162

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Biochemical and biological properties of Lonomia obliqua bristle extract

Autor: L. C. Carrijo-Carvalho, A. M. Chudzinski-Tavassi

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 2, Pp 159-171 (2006)
Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 12, Issue: 2, Pages: 159-171, Published: APR 2006
Journal of Venomous Animals and Toxins including Tropical Diseases v.12 n.2 2006
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565f149d5fa615ec2ebd9d95b65250a
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200002

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New insight into the mechanism of Lonomia obliqua envenoming: toxin involvement and molecular approach

Autor: M P, Alvarez Flores, M, Zannin, A M, Chudzinski-Tavassi

Publikováno v: Pathophysiology of haemostasis and thrombosis. 37(1)

Despite the nearly worldwide distribution of Lepidoptera, there are few species with clear documentation of adverse reactions in humans. Most syndromes caused by Lepidoptera are consequences of direct contact with the hairs or setae of caterpillars.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d733292e45ef7e53edb3f36b48baa60
https://pubmed.ncbi.nlm.nih.gov/20714126

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rACLF, a recombinant snake venom metalloprotease, activates endothelial cells in vitro

Autor: M. Fritzen, A. M. Chudzinski-Tavassi, C. K. De Moraes, Heloisa S. Selistre-de-Araujo

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases v.14 n.1 2008
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 14, Issue: 1, Pages: 113-127, Published: 2008
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 14, Iss 1, Pp 113-127 (2008)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ef3d82baf607b6bd3eede839ceddb0
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100009

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A prothrombin activator serine protease from the Lonomia obliqua caterpillar venom (Lopap) biochemical characterization

Autor: C V, Reis, F C, Portaro, S A, Andrade, M, Fritzen, B L, Fernandes, C A, Sampaio, A C, Camargo, A M, Chudzinski-Tavassi

Publikováno v: Thrombosis research. 102(5)

Lonomia obliqua venom causes a severe consumptive coagulopathy, which can lead to a hemorrhagic syndrome. The crude bristles extract displays a procoagulant activity due to a Factor X and to a prothrombin activating activity. Here, we describe a 69 k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2e45f22af4ce5246cf1253bcd5ac420
https://pubmed.ncbi.nlm.nih.gov/11395128

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A Ca++ activated serine protease (LOPAP) could be responsible for the haemorrhagic syndrome caused by the caterpillar Lonomia obliqua. L obliqua Prothrombin Activator Protease

Autor: C V, Reis, E M, Kelen, S H, Farsky, F C, Portaro, C A, Sampaio, B L, Fernandes, A C, Camargo, A M, Chudzinski-Tavassi

Publikováno v: Lancet (London, England). 353(9168)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ecbc2bdeca5db010bf5c0b6a662d5c48
https://pubmed.ncbi.nlm.nih.gov/10371584

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Akademický článek

Preclinical evaluation of Amblyomin-X, a Kunitz-type protease inhibitor with antitumor activity

Autor: Durvanei A. Maria, Sonia Elisabete A.L. Will, Rosemary V. Bosch, Jean G. Souza, Juliana M. Sciani, Mauricio B. Goldfeder, Giuliana G. Rondon, Ana M. Chudzinski-Tavassi

Publikováno v: Toxicology Reports, Vol 6, Iss , Pp 51-63 (2019)

Amblyomin-X, a Kunitz-type protease inhibitor, is a recombinant protein that selectively induces apoptosis in tumor cells and promotes tumor reduction in vivo in melanoma animal models. Furthermore, Amblyomin-X was able to drastically reduce lung met

Externí odkaz: https://doaj.org/article/10194f3bcbaf480f88ffcab08a20c7d6

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