Zobrazeno 1 - 10
of 778
pro vyhledávání: '"A. M. Binley"'
Autor:
Tommy Tong, Alessio D'Addabbo, Jiamin Xu, Himanshi Chawla, Albert Nguyen, Paola Ochoa, Max Crispin, James M Binley
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011452 (2023)
Recent HIV-1 vaccine development has centered on "near native" soluble envelope glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and apically (between gp120 and gp41). These mutations have been leveraged for u
Externí odkaz:
https://doaj.org/article/da0b002c81154636a46ef072541aaecf
Autor:
Emma T. Crooks, Francisco Almanza, Alessio D’Addabbo, Erika Duggan, Jinsong Zhang, Kshitij Wagh, Huihui Mou, Joel D. Allen, Alyssa Thomas, Keiko Osawa, Bette T. Korber, Yaroslav Tsybovsky, Evan Cale, John Nolan, Max Crispin, Laurent K. Verkoczy, James M. Binley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion pep
Externí odkaz:
https://doaj.org/article/30ea4c2a548142c8b204822f276498bc
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Current global-scale nitrogen (N) budgets quantifying anthropogenic impacts on the N cycle do not explicitly consider nitrate storage in the vadose zone. Here, using estimates of depth to groundwater and nitrate leaching between 1900–2000, the auth
Externí odkaz:
https://doaj.org/article/37545a5b8b744e0c9300f74ac11545fa
Publikováno v:
AIDS Res Hum Retroviruses
Human immunodeficiency virus type-1 (HIV-1) antigenic variation poses a great challenge for vaccine immunogen design to elicit broadly neutralizing antibodies (bNAbs). Over the last 10-15 years, great progress has been made to understand the conserve
Autor:
Ema T Crooks, Samantha L Grimley, Michelle Cully, Keiko Osawa, Gillian Dekkers, Kevin Saunders, Sebastian Rämisch, Sergey Menis, William R Schief, Nicole Doria-Rose, Barton Haynes, Ben Murrell, Evan Mitchel Cale, Amarendra Pegu, John R Mascola, Gestur Vidarsson, James M Binley
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007024 (2018)
The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with othe
Externí odkaz:
https://doaj.org/article/07efec52348049c5a19cfd97bdec12dd
Autor:
Nicole A Doria-Rose, Han R Altae-Tran, Ryan S Roark, Stephen D Schmidt, Matthew S Sutton, Mark K Louder, Gwo-Yu Chuang, Robert T Bailer, Valerie Cortez, Rui Kong, Krisha McKee, Sijy O'Dell, Felicia Wang, Salim S Abdool Karim, James M Binley, Mark Connors, Barton F Haynes, Malcolm A Martin, David C Montefiori, Lynn Morris, Julie Overbaugh, Peter D Kwong, John R Mascola, Ivelin S Georgiev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006148 (2017)
Computational neutralization fingerprinting, NFP, is an efficient and accurate method for predicting the epitope specificities of polyclonal antibody responses to HIV-1 infection. Here, we present next-generation NFP algorithms that substantially imp
Externí odkaz:
https://doaj.org/article/8a81c72949514c31829e9f7bf5c3f8b9
Autor:
Francisco Almanza, Jinsong Zhang, Yaroslav Tsybovsky, Erika Duggan, Max Crispin, Kshitij Wagh, John P. Nolan, Joel D. Allen, Keiko Osawa, James M. Binley, Huihui Mou, Alyssa Thomas, Alessio D'addabbo, Evan M. Cale, Emma T. Crooks, Laurent Verkoczy, Bette T. Korber
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
PLoS Pathogens
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion pep
Autor:
Ema T Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O'Dell, Celia LaBranche, James E Robinson, David C Montefiori, Krisha McKee, Sean X Du, Nicole Doria-Rose, Peter D Kwong, John R Mascola, Ping Zhu, William R Schief, Richard T Wyatt, Robert G Whalen, James M Binley
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004932 (2015)
Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually potent nAb titers developed in 2 of 8 rabbits
Externí odkaz:
https://doaj.org/article/65b7f896418649c1899f642d72673ccb
Publikováno v:
Hydrology and Earth System Sciences, Vol 1, Iss 2, Pp 291-302 (1997)
Abstract: Better understanding of field-scale unsaturated zone transport mechanisms is required if the fate of contaminants released at the surface is to be predicted accurately. Interpretation of results from direct tracer sampling in terms of opera
Externí odkaz:
https://doaj.org/article/c5bc28a2b5054140a3c52047df257d16
Autor:
Johannes S Gach, Heribert Quendler, Tommy Tong, Kristin M Narayan, Sean X Du, Robert G Whalen, James M Binley, Donald N Forthal, Pascal Poignard, Michael B Zwick
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72054 (2013)
Primary isolates of HIV-1 resist neutralization by most antibodies to the CD4 binding site (CD4bs) on gp120 due to occlusion of this site on the trimeric spike. We describe 1F7, a human CD4bs monoclonal antibody that was found to be exceptionally pot
Externí odkaz:
https://doaj.org/article/cce40e1dc2ad4d5893581ac52a615e3f