Zobrazeno 1 - 10
of 67
pro vyhledávání: '"A. M. Babsky"'
Publikováno v:
Біологічні студії, Vol 16, Iss 4, Pp 19-32 (2022)
Background. Drug delivery systems (DDS) have demonstrated a significant ability to overcome many of the challenges associated with the delivery of hydrophobic chemotherapeutic compounds to tumor tissues. However, hepatotoxicity and suppression of the
Externí odkaz:
https://doaj.org/article/82f707fcfcde49b1a1370aea6bb87fbf
Publikováno v:
Біологічні студії, Vol 16, Iss 2, Pp 19-28 (2022)
Background. Many types of tumors are sensitive to changes in prooxidant-antioxidant balance. Thus, further studies on reactive oxygen species inducing antitumor drugs that generate oxidative stress-dependent cytotoxic effects are promising. Our previ
Externí odkaz:
https://doaj.org/article/553c1a2ca1fa4586a692877e12226dbe
Publikováno v:
Біологічні студії, Vol 15, Iss 4, Pp 37-48 (2021)
Background. Previous studies have shown a pronounced cytotoxic effect of thiazole derivatives in combination with polymeric carriers on tumor cells. At the same time, the derivatives were not cytotoxic against non-cancerous cells in vitro. It was sho
Externí odkaz:
https://doaj.org/article/1af81c10b43a4fac9a0bd8353fa537a7
Autor:
M. V. Popovych, Ya. R. Shalai, V. P. Hreniukh, O. R. Kulachkovskyy, S. M. Mandzynets, N. E. Mitina, O. S. Zaichenko, A. M. Babsky
Publikováno v:
Біологічні студії, Vol 15, Iss 2, Pp 15-24 (2021)
Background. A pronounced cytotoxic action of the thiazole derivatives complexed with polymeric carriers on tumor cells in vitro was reported earlier, while no cytotoxicity of these compounds was detected toward noncancerous cells. It was found that t
Externí odkaz:
https://doaj.org/article/311c245da19a4933901364fa4d4cb27a
Publikováno v:
The Ukrainian Biochemical Journal, Vol 93, Iss 3, Pp 61-67 (2021)
Thiazole derivatives were shown to have toxic effects in vitro on cancer cells of different origin and can be considered as potentially antineoplastic, but their effect on the normal tissues needs to be studied. In this research the newly synthesized
Externí odkaz:
https://doaj.org/article/70ac6bb362184dab867c6878c0bcdb10
Autor:
N. S. Finiuk, O. Yu. Klyuchivska, I. I. Ivasechko, N. E. Mitina, Yu. V. Ostapiuk, M. D. Obushak, O. S. Zaichenko, A. M. Babsky, R. S. Stoika
Publikováno v:
The Ukrainian Biochemical Journal, Vol 93, Iss 3, Pp 39-51 (2021)
Thiazole derivatives are perspective antitumor compounds characterized by a broad range of bioactivity, while polymeric carriers are widely used to enhance the efficiency of biological action of drugs, improve their biocompatibility and water solubil
Externí odkaz:
https://doaj.org/article/ec798388f6fa40e09972e029bd7eb46e
Publikováno v:
Біологічні студії, Vol 14, Iss 4, Pp 15-22 (2020)
Background. The influence in vitro of thiazole derivative 8-methyl-2-Me-7-[trifluoromethyl-phenylmethyl]-pyrazolo-[4,3-e]-[1,3]-thiazolo-[3,2-a]-pyrimidin-4(2H)-one (PP2) on the level of lipid peroxidation products, superoxide anion radical and ant
Externí odkaz:
https://doaj.org/article/f23b705676db4eaab02fa5dff6f9bff5
Autor:
V. P. Hreniukh, N. S. Finiuk, Ya. R. Shalai, B. O. Manko, B. V. Manko, Yu. V. Ostapiuk, O. R. Kulachkovskyy, M. D. Obushak, R. S. Stoika, A. M. Babsky
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 2, Pp 121-130 (2020)
Thiazole derivatives have cytotoxic effects towards tumor cells, such as glioblastoma, melanoma, leukemia and lymphoma. However, the intracellular mechanism of this action is not clear. The aim of our study was to investigate the action of N-(5-benzy
Externí odkaz:
https://doaj.org/article/0d95acffb7b64a4e9267c50ffed7c816
Autor:
Ya. R. Shalai, M. V. Popovych, O. R. Kulachkovskyy, V. P. Hreniukh, S. M. Mandzynets, N. S. Finiuk, A. M. Babsky
Publikováno v:
Біологічні студії, Vol 13, Iss 1, Pp 51-60 (2019)
The influence of newly synthesized thiazole derivative N-(5-benzyl-1,3-thiazol-2-yl)-3,5-dimethyl-1-benzofuran-2-carboxamide on cellular ultrastructure and antioxidant system activity in lymphoma cells was studied in vitro. A pronounced cytotoxic a
Externí odkaz:
https://doaj.org/article/050d1761426040249facd3d3443c5410
Autor:
N. S. Finiuk, I. I. Ivasechko, O. Yu. Klyuchivska, Yu. V. Ostapiuk, V. P. Hreniukh, Ya. R. Shalai, V. S. Matiychuk, M. D. Obushak, A. M. Babsky, R. S. Stoika
Publikováno v:
The Ukrainian Biochemical Journal, Vol 91, Iss 2, Pp 29-39 (2019)
Derivatives of 2-amino-5-benzylthiazole are heterocyclic pharmacophores that exhibit different pharmacological activities including anticancer action. The mechanisms of such action of these compounds are not clear. The aim of the present study was to
Externí odkaz:
https://doaj.org/article/27ac830802be498180465ac22808e03e