Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling

Autor: Andrew M. Anisfeld, Heidi R. Kast-Woelbern, Hans Lee, Yanqiao Zhang, Florence Y. Lee, Peter A. Edwards

Publikováno v: Journal of Lipid Research, Vol 46, Iss 3, Pp 458-468 (2005)

Three genes, fibrinogen-α (FBGα), -β, and -γ, encode proteins that make up the mature FBG protein complex. This complex is secreted from the liver and plays a key role in coagulation in response to vascular disruption. We identified all three FBG

Externí odkaz: https://doaj.org/article/d308df5bda65440aa920c9eb7d2440fe

BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis

Autor: Peter A. Edwards, Heidi R. Kast, Andrew M. Anisfeld

Publikováno v: Journal of Lipid Research, Vol 43, Iss 1, Pp 2-12 (2002)

During the last three years there have been a plethora of publications on the liver X-activated receptors (LXRα, NR1H3, and LXRβ, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role these n

Externí odkaz: https://doaj.org/article/a690b59beafe47ccade2c583181b895c

Oral abstracts 1: SpondyloarthropathiesO1. Detecting axial spondyloarthritis amongst primary care back pain referrals

Autor: C. Harris, D. Remedios, T. Aptowitzer, A. Keat, L. Hamilton, G. Guile, A. Belkhiri, D. Newman, A. Toms, A. Macgregor, K. Gaffney, L. Morton, G. T. Jones, A. G. MacDonald, C. Downham, G. J. Macfarlane, W. Tillett, D. Jadon, D. Wallis, L. Costa, N. Waldron, N. Griffith, C. Cavill, E. Korendowych, C. de Vries, N. McHugh, O. Iaremenko, D. Fedkov, P. Emery, D. Baeten, J. Sieper, J. Braun, D. van der Heijde, I. McInnes, J. Van Laar, R. Landewe, B. P. Wordsworth, J. Wollenhaupt, H. Kellner, I. Paramarta, A. Bertolino, A. M. Wright, W. Hueber, N. Sofat, C. Smee, M. Hermansson, J. Wajed, K. Sanyal, P. Kiely, M. Howard, F. A. Howe, T. R. Barrick, A. M. Abraham, M. S. Pearce, K. D. Mann, R. M. Francis, F. Birrell, A. Carr, I. Macleod, W.-F. Ng, A. Kavanaugh, C. Chattopadhyay, D. Gladman, P. Mease, G. Krueger, W. Xu, N. Goldstein, A. Beutler, X. Baraliakos, D. D. Laurent, S. Gsteiger, P. G. Conaghan, C. G. Peterfy, J. DiCarlo, E. Olech, A. R. Alberts, J. A. Alper, J. Devenport, A. M. Anisfeld, O. M. Troum, P. Cooper, M. Gimpel, G. Deakin, K. Jameson, M. Godtschailk, S. Gadola, M. Stokes, C. Cooper, C. Gordon, K. Kalunian, M. Petri, V. Strand, B. Kilgallen, A. Barry, D. Wallace, C. A. Flurey, M. Morris, J. Pollock, R. Hughes, P. Richards, S. Hewlett

Background: Inflammatory back pain (IBP) is an early feature of ankylosing spondylitis (AS) and its detection offers the prospect of early diagnosis of AS. However, since back pain is very common but only a very small minority of back pain sufferers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7966cef50559cc7ce7e54c88ea8e92b7
http://doc.rero.ch/record/290228/files/kes118.pdf

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Autor: Peter A. Edwards, Puiying A. Mak, Heidi R. Kast-Woelbern, Andrew M. Anisfeld

Publikováno v: Journal of Lipid Research, Vol 43, Iss 12, Pp 2037-2041 (2002)

Affymetrix microarray data and Northern blot assays demonstrated that phospholipid transfer protein (PL222222222216) was induced 6-fold when either murine or human macrophages were incubated in the presence of ligands for the liver X receptor (LXR) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d03d5baadbf12dc582da5e9b65a6f83
https://doi.org/10.1194/jlr.c200014-jlr200

CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene

Autor: Andrew M. Anisfeld, Johan Ericsson, Heidi Rachelle Kast, Peter A. Edwards, Catherine M. Nguyen

Publikováno v: Journal of Lipid Research, Vol 42, Iss 8, Pp 1266-1272 (2001)

The CTP:phosphocholine cytidylyltransferase (CT) gene encodes the rate-controlling enzyme in the phosphatidylcholine biosynthesis pathway. CTα mRNA levels, like farnesyl diphosphate synthase and the LDL receptor, are repressed when human or rodent c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e04c831ade4bc273a974e09fe04abf2
http://www.sciencedirect.com/science/article/pii/S0022227520315777