Výsledky vyhledávání - "A. M. Ali Imam"

Investigation of the spatial structure and interactions of the genome at sub-kilobase-pair resolution using T2C

Autor: Kerstin S. Wendt, Harmen J.G. van de Werken, Jessica Zuin, Michael Lesnussa, Petros Kolovos, Christel E M Kockx, Frank Grosveld, Rutger W W Brouwer, Tobias Knoch, A. M. Ali Imam, Wilfred F. J. van IJcken, Nick Kepper

Publikováno v: Nature Protocols, 13(3), 459-477. Nature Publishing Group

Chromosome conformation capture (3C) and its derivatives (e.g., 4C, 5C and Hi-C) are used to analyze the 3D organization of genomes. We recently developed targeted chromatin capture (T2C), an inexpensive method for studying the 3D organization of gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b439f3f1522391f3f726238751465060
https://pure.eur.nl/en/publications/ab145eb6-b5ba-46f5-aada-a1c5c5f4881d

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The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes

Autor: Nick Kepper, Harmen J.G. van de Werken, Anis Abuseiris, Petros Kolovos, Rutger W W Brouwer, Jessica Zuin, Malte Wachsmuth, Wilfred F. J. van IJcken, Michael Lesnussa, Christel E M Kockx, Frank Grosveld, Tobias Knoch, A. M. Ali Imam, Kerstin S. Wendt

Publikováno v: Epigenetics & Chromatin, 9:58. BioMed Central Ltd.
Epigenetics & Chromatin

BackgroundThe dynamic three-dimensional chromatin architecture of genomes and its co-evolutionary connection to its function—the storage, expression, and replication of genetic information—is still one of the central issues in biology. Here, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62654b2f034ee2e3c1438ee1b93ba9a1
https://doi.org/10.1186/s13072-016-0089-x

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An embryonic specific repressor element located 3' to the Ay-globin gene influences transcription of the human beta globin locus in transgenic mice

Autor: John Strouboulis, Mariken de Krom, John Kong-a-San, A. M. Ali Imam, Frank Grosveld, Nicholas P. Anagnou, Eleni Katsantoni

Publikováno v: Experimental Hematology, 32, 224-233. Elsevier Inc.

Objective Persistent expression of the human fetal γ-globin genes in the adult stage is often associated with naturally occurring deletions in the human β-globin locus. The mapping of the 5′ breakpoints of these deletions within the A γ- to δ-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4ef27c4d703a7a7db0801256394905
https://pure.eur.nl/en/publications/56c42b32-0ebe-4663-8772-3807cabe394b

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Transcription factors induced by interferons α and γ

Autor: Andrew M. Ackrill, Ian M. Kerr, Trevor Clive Dale, A. M. Ali Imam, George Stark Stark

Publikováno v: Nucleic Acids Research. 18:6573-6580

Factors induced by interferons (IFNs) bind to the IFN-stimulated response elements (ISREs) of many genes. In human cells treated with type I (alpha, beta) IFN, factor E is induced in about 1 min and factor M after about 1 hr. Factor G is induced afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad8985f98e3ae4512cee491a3b44c415
https://doi.org/10.1093/nar/18.22.6573

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Succesful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vector

Autor: A. M. Ali Imam, Rogier Louwen, Ruvalic M. Buijs-Offerman, Bob J. Scholte, Frank Grosveld, Pascal van der Wegen, Maarten Sinaasappel

Publikováno v: Molecular Therapy, 12(2), 374-381. Cell Press
Molecular Therapy, 13(2), 374-381. Cell Press

Treatment of congenital and acquired liver disease is one of the main issues in the field of gene therapy. Self-inactivating lentiviral vectors have several potential advantages over alternative systems. We have constructed a self-inactivating lentiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ff1658e4b22b9b57f478f4c15a3e79
https://pure.eur.nl/en/publications/29f5f8a9-590a-42b4-ab5d-9ba0550a3138

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The role of the –50 region of the human γ-globin gene in switching

Autor: Frank Grosveld, Dubravka Drabek, Maria Serafina Ristaldi, Daniela Poddie, Nikos Yannoutsous, Antonio Cao, Joost Gribnau, A. M. Ali Imam

Publikováno v: EMBO Journal, 20(18), 5242-5249. Wiley-Blackwell

During the switch from human gamma- (fetal) to beta- (adult) globin gene expression, the gamma and beta genes are expressed competitively by an alternating transcription mechanism. The -50 region of the gamma gene promoter has been proposed to be res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138ecaab546ecc37f2e9e45429bf4ad4
https://europepmc.org/articles/PMC125618/

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Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli

Autor: Stefania Bottardi, Frank Grosveld, David J. Sherratt, Rick Janssens, Eleni Katsantoni, A. M. Ali Imam, Albert W. K. Wai, Mariken de Krom, George P. Patrinos

Publikováno v: Nucleic Acids Research, 28(12), 65-65. Oxford University Press

We report here modifications of human beta-globin PAC clones by homologous recombination in Escherichia coli DH10B, utilising a plasmid temperature sensitive for replication, the recA gene and a wild-type copy of the rpsL gene which allows for an eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd3ff6ee3ed5a622ae219b3239ffa50
https://pubmed.ncbi.nlm.nih.gov/10871388

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TBP binding and the rate of transcription initiation from the human beta-globin gene

Autor: Ernie de Boer, Frank Grosveld, Eugenia Spanopoulou, A. M. Ali Imam, Michael Antoniou

Publikováno v: Nucleic acids research. 23(17)

DNA-protein interaction studies in vitro revealed several factors binding over the TATA box and the region of transcription initiation (cap) site of the human beta-globin promoter; TATA binding protein TBP at -30, Sp1 at -19, GATA-1 at -12 and +5, YY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df66add9f0366123e57620f84a2c21be
https://pubmed.ncbi.nlm.nih.gov/7567458

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Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells

Autor: George R. Stark, Trevor Clive Dale, A. M. Ali Imam, Ian M. Kerr

Publikováno v: Proceedings of the National Academy of Sciences. 86:1203-1207

The highly conserved interferon (IFN)-stimulated regulatory elements of the human genes 6-16 and 9-27 bind to one or more proteins (E factor) detected in extracts of human Bristol 8 B cells or human foreskin fibroblast cells treated with IFN-alpha. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49710cbc9dd0e0cb024e92a76c1faf7d
https://doi.org/10.1073/pnas.86.4.1203

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