Zobrazeno 1 - 10
of 1 257
pro vyhledávání: '"A. M., Sapozhnikov"'
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 905-912 (2024)
Currently, a large amount of data has demonstrated that many types of tumor cells, in contrast to their non-transformed forms, are characterized by the translocation of intracellular heat shock proteins 70 kDa (HSP70) to the surface of the plasma mem
Externí odkaz:
https://doaj.org/article/4289fa96b7b24ec9a74f34aa51c7c532
Publikováno v:
Медицинская иммунология, Vol 26, Iss 4, Pp 657-662 (2024)
Heat shock proteins of the 70 kDa family (HSP70) are intracellular chaperones necessary for the cell to maintain protein homeostasis. In the cytosol, under normal conditions, these proteins promote the correct folding of proteins, preventing their ag
Externí odkaz:
https://doaj.org/article/681dfb13eb6c4c3ebdb3ea5d6918ddbd
Autor:
Daniel M. Sapozhnikov, Moshe Szyf
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTTransgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/Cas9-based epigenetic editing technique to mod
Externí odkaz:
https://doaj.org/article/4d383914f15e48b3a9642ed8b465d9f0
Autor:
Nadezhda A. Alekseeva, Anna A. Boyko, Marina A. Shevchenko, Maria V. Grechikhina, Maria A. Streltsova, Ludmila G. Alekseeva, Alexander M. Sapozhnikov, Sergey M. Deyev, Elena I. Kovalenko
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2398 (2024)
Background/objectives: The functional activity of a certain tumor determines the effectiveness of primary NK cells and NK-92 cell line-based cancer therapy; their therapeutic effectiveness against different tumors can vary. This work provides a direc
Externí odkaz:
https://doaj.org/article/e985cae832ee4d638c6ef4804884ca5b
Autor:
Elad Lax, Sonia Do Carmo, Yehoshua Enuka, Daniel M. Sapozhnikov, Lindsay A. Welikovitch, Niaz Mahmood, Shafaat A. Rabbani, Liqing Wang, Jonathan P. Britt, Wayne W. Hancock, Yosef Yarden, Moshe Szyf
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The Methyl-CpG-Binding Domain Protein family has been implicated in neurodevelopmental disorders. The Methyl-CpG-binding domain 2 (Mbd2) binds methylated DNA and was shown to play an important role in cancer and immunity. Some evidence linke
Externí odkaz:
https://doaj.org/article/ac756fae07a44e51b83b8e00c01221ca
Autor:
M. A. Shevchenko, D. G. Garbuz, A. I. Davletshin, A. A. Boyko, M. B. Evgen'ev, A. M. Sapozhnikov
Publikováno v:
Медицинская иммунология, Vol 25, Iss 3, Pp 447-452 (2023)
Heat shock proteins 70 kDa (HSP70) protect intracellular proteins from the damaging effects of stress factors of various natures. Moreover, HSP70 play an important role in the vital activity of cells under normal physiological conditions, performing
Externí odkaz:
https://doaj.org/article/0018c8853e7e4e66973163d3028b5883
Autor:
Daniel M. Sapozhnikov, Moshe Szyf
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Off-target mutagenesis of CRISPR/Cas systems must be solved to facilitate safe gene therapy. Here, we report a novel approach, termed "PROTECTOR", to shield known off-target sites by directing the binding of an orthologous nuclease-dead Cas
Externí odkaz:
https://doaj.org/article/5caa7ecd6a084a3ab948ff83a913264f
Autor:
Ludmila G. Alekseeva, Olga V. Ovsyanikova, Alexey A. Schulga, Maria V. Grechikhina, Olga A. Shustova, Elena I. Kovalenko, Elena V. Svirshchevskaya, Sergey M. Deyev, Alexander M. Sapozhnikov
Publikováno v:
Cells, Vol 13, Iss 4, p 317 (2024)
(1) Background: We have previously shown that the use of an artificial supramolecular two-component system based on chimeric recombinant proteins 4D5scFv-barnase and barstar-heat shock protein 70 KDa (HSP70) allows targeted delivery of HSP70 to the s
Externí odkaz:
https://doaj.org/article/2b5af5d8233f457481386f74029cfef6
Autor:
Daniel M. Sapozhnikov, Moshe Szyf
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-26 (2021)
The causal relationship between DNA demethylation and gene expression regulation has not yet been fully resolved. Here the authors develop a nuclease-dead Cas9 (dCas9) and gRNA site-specific targeting approach to physically block DNA methylation at s
Externí odkaz:
https://doaj.org/article/ec5522b1496a4c3d90ef8ee39e17ce5a
Autor:
Ivan V. Bogdanov, Maria A. Streltsova, Elena I. Kovalenko, Alexander M. Sapozhnikov, Pavel V. Panteleev, Tatiana V. Ovchinnikova
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1316 (2023)
The only human cathelicidin, LL-37, is a host defense antimicrobial peptide with antimicrobial activities against protozoans, fungi, Gram(+) and Gram(−) bacteria, and enveloped viruses. It has been shown in experiments in vitro that LL-37 is able t
Externí odkaz:
https://doaj.org/article/a7e582cdad5041c2ac2cb32bc1170a17