Zobrazeno 1 - 10
of 5 037
pro vyhledávání: '"A. M., Levine"'
Autor:
Stelian Camara Dit Pinto, Jalal Cherkaoui, Debarshi Ghosh, Valentine Cazaubon, Kenza E. Benzeroual, Steven M. Levine, Mohammed Cherkaoui, Gagan K. Sood, Sharmila Anandasabapathy, Sadhna Dhingra, John M. Vierling, Nicolas R. Gallo
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Addressing drug-induced liver injury is crucial in drug development, often causing Phase III trial failures and market withdrawals. Traditional animal models fail to predict human liver toxicity accurately. Virtual twins of human organs pres
Externí odkaz:
https://doaj.org/article/9c77922ea234497ebfb17e16f09b1216
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Purpose Chimeric antigen receptor T-cell (CART) therapy has shown clinical efficacy in refractory and relapsed large B-cell lymphomas, but is associated with serious acute and long-term toxicities. To understand the patient perspective, we m
Externí odkaz:
https://doaj.org/article/d698902dbf064ab5803aeb8e9a30c975
Autor:
P.-C. Violet, N. Munyan, H.F. Luecke, Y. Wang, J. Lloyd, K. Patra, K. Blakeslee, I.C. Ebenuwa, M. Levine
Publikováno v:
Redox Biology, Vol 78, Iss , Pp 103425- (2024)
Ascorbic acid (AA, vitamin C) and dehydroascorbic acid (DHA) constitute a biological couple. No technique can accurately, independently, and simultaneously quantify both members of the couple in animal and human samples, thereby constraining advances
Externí odkaz:
https://doaj.org/article/e2a760a1cac848698d5833faa5e9b388
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111299- (2024)
Summary: It is advantageous to culture the ex vivo retina and other tissues at the air-liquid interface to allow for more efficient gas exchange. However, gene delivery to these cultures can be challenging. Electroporation is a fast and robust method
Externí odkaz:
https://doaj.org/article/703dce7f7a784c8388073165b9f9aed2
Autor:
Rina Das, Md. Ahshanul Haque, Karen L. Kotloff, Dilruba Nasrin, M. Jahangir Hossain, Dipika Sur, Tahmeed Ahmed, Myron M. Levine, Robert F. Breiman, A. S. G. Faruque, Matthew C. Freeman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Enteric viral pathogens are associated with a significant burden of childhood morbidity and mortality. We investigated the relationship between viral pathogens and child growth among under-5 children. We analyzed data from 5572/22,567 childr
Externí odkaz:
https://doaj.org/article/5862d5236ef24ce3a24202f043ebea07
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-6 (2024)
Abstract The oceans sequester a vast amount of carbon thus playing a central role in the global carbon cycle. Assessing how carbon cycling will be impacted by climate change requires an improved understanding of microbial dynamics, which are responsi
Externí odkaz:
https://doaj.org/article/099bc856424d44348309616275f4d13a
Autor:
Jayaum S. Booth, Rekha R. Rapaka, Monica A. McArthur, Stephanie Fresnay, Thomas C. Darton, Christoph J. Blohmke, Claire Jones, Claire S. Waddington, Myron M. Levine, Andrew J. Pollard, Marcelo B. Sztein
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Despite decades of intense research, our understanding of the correlates of protection against Salmonella Typhi (S. Typhi) infection and disease remains incomplete. T follicular helper cells (TFH), an important link between cellular and humoral immun
Externí odkaz:
https://doaj.org/article/2584ad89ecfd40c2bb661c8fb10159e5
Autor:
Franklin R. Toapanta, Jingping Hu, Kari Ann Shirey, Paula J. Bernal, Myron M. Levine, Thomas C. Darton, Claire S. Waddington, Andrew J. Pollard, Marcelo B. Sztein
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
An oral Controlled Human Infection Model (CHIM) with wild-type S. Typhi was re-established allowing us to explore the development of immunity. In this model, ~55% of volunteers who received the challenge reached typhoid diagnosis criteria (TD), while
Externí odkaz:
https://doaj.org/article/7f2e05bb0a404438a4c9919701980c1f
Autor:
Rylee Matheson, Courtney L. Sexton, Catherine F. Wise, Janice O’Brien, Amber J. Keyser, Mandy Kauffman, Matthew D. Dunbar, DAP Consortium, Joshua M. Akey, Brooke Benton, Elhanan Borenstein, Marta G. Castelhano, Amanda E. Coleman, Kate E. Creevy, Kyle Crowder, Virginia R. Fajt, Annette L. Fitzpatrick, Unity Jeffery, Erica C Jonlin, Matt Kaeberlein, Elinor K. Karlsson, Kathleen F. Kerr, Jonathan M. Levine, Jing Ma, Robyn L McClelland, Daniel E.L. Promislow, Audrey Ruple, Stephen M. Schwartz, Sandi Shrager, Noah Snyder-Mackler, M. Katherine Tolbert, Silvan R. Urfer, Benjamin S. Wilfond
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionCompanion animals offer a unique opportunity to investigate risk factors and exposures in our shared environment. Passive sampling techniques have proven effective in capturing environmental exposures in dogs and humans.MethodsIn a pilot
Externí odkaz:
https://doaj.org/article/d026a8041d8a468c8110320df8400a04
Autor:
Kenneth I. Aycock, Tom Battisti, Ashley Peterson, Jiang Yao, Steven Kreuzer, Claudio Capelli, Sanjay Pant, Pras Pathmanathan, David M. Hoganson, Steve M. Levine, Brent A. Craven
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Computational models of patients and medical devices can be combined to perform an in silico clinical trial (ISCT) to investigate questions related to device safety and/or effectiveness across the total product life cycle. ISCTs can potentially accel
Externí odkaz:
https://doaj.org/article/ccb778af6883417ab746f816059b55be