Zobrazeno 1 - 10
of 26
pro vyhledávání: '"A. Lyndsay Drayer"'
Publikováno v:
European Journal of Haematology, 83(3), 235-245. Wiley
Objective:During megakaryopoiesis, hematopoietic progenitor cells in the bone marrow proliferate and ultimately differentiate in mature megakaryocytes (MK). We and others have recently described a role for the mammalian target of Rapamycin (mTOR) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ccfac970830f3c89afaf18ac44d0f8
https://doi.org/10.1111/j.1600-0609.2009.01263.x
https://doi.org/10.1111/j.1600-0609.2009.01263.x
Autor:
Gerald de Haan, Sandra Olthof, A. Lyndsay Drayer, Ido P. Kema, Vincent W. Bloks, Pieter J. J. Sauer, Nel R. Blom, Folkert Kuipers, Janine K. Kruit, Edo Vellenga
Publikováno v:
The Journal of Biological Chemistry, 283(10), 6281-6287. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Mutations in either ABCG5 or ABCG8 cause sitosterolemia, an inborn error of metabolism characterized by high plasma plant sterol concentrations. Recently, macrothrombocytopenia was described in a number of sitosterolemia patients, linking hematologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc76d544f8a30d3007e1eaffbf6bed7
https://doi.org/10.1074/jbc.m706689200
https://doi.org/10.1074/jbc.m706689200
Autor:
Jan Jacob Schuringa, Gwenny M. Fuhler, Edo Vellenga, Sandra Olthof, Paul J. Coffer, A. Lyndsay Drayer
Publikováno v:
Blood, 111(1), 359-368. AMER SOC HEMATOLOGY
Patients with myelodysplasia (MDS) show a differentiation defect in the multipotent stem-cell compartment. An important factor in stem-cell differentiation is their proper localization within the bone marrow microenvironment, which is regulated by st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82e1f2ae84f402850460f0719827f2a
https://doi.org/10.1182/blood-2006-11-060632
https://doi.org/10.1182/blood-2006-11-060632
Publikováno v:
STEM CELLS, 24(1), 105-114. Wiley-Blackwell
Thrombopoietin (TPO) is a potent regulator of megakaryopoiesis and stimulates megakaryocyte (MK) progenitor expansion and MK differentiation. In this study, we show that TPO induces activation of the mammalian target of rapamycin (mTOR) signaling pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f291aca41bb745ed0312f9ac296206
https://doi.org/10.1634/stemcells.2005-0062
https://doi.org/10.1634/stemcells.2005-0062
Publikováno v:
Journal of Leukocyte Biology, 77(2), 257-266. FEDERATION AMER SOC EXP BIOL
Patients with myelodysplasia suffer from recurrent bacterial infections as a result of differentiation defects of the myeloid lineage and a disturbed functioning of neutrophilic granulocytes. Important physiological activators of neutrophils are the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b1ed5cd1499295100fd913796405e1
https://research.rug.nl/en/publications/0c934cc2-01a9-414c-9004-e862a44e623f
https://research.rug.nl/en/publications/0c934cc2-01a9-414c-9004-e862a44e623f
Publikováno v:
STEM CELLS, 23(2), 240-251. Wiley-Blackwell
Stem cell factor (SCF) has a potent synergistic effect during megalkaryopoiesis when administered in combination with the major megalkaryocytic cytokine, thrombopoietin (TPO). In this study we analyzed the underlying mechanisms with regard to STAT5 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46633ef59169e025f1198311b5e37c1e
https://doi.org/10.1634/stemcells.2004-0153
https://doi.org/10.1634/stemcells.2004-0153
Autor:
Edo Vellenga, Gwenny M. Fuhler, Karen A. Cadwallader, A. Lyndsay Drayer, Gerlinde J. Knol, Edwin R. Chilvers
Publikováno v:
Journal of Leukocyte Biology, 76(1), 254-262. FEDERATION AMER SOC EXP BIOL
The production of reactive oxygen species (ROS) by human neutrophils is imperative for their bactericidal activity. Proinflammatory agents such as granulocyte macrophage-colony stimulating factor (GM-CSF) can prime ROS production in response to chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afd0ff2df9d214f2b8bb3760dc655ac
https://doi.org/10.1189/jlb.0204071
https://doi.org/10.1189/jlb.0204071
Publikováno v:
Blood, 101(3), 1172-1180. AMER SOC HEMATOLOGY
Neutrophils from patients with myelodysplastic syndrome (MDS) show a disturbed differentiation pattern and are generally dysfunctional. To study these defects in more detail, we investigated reactive-oxygen species (ROS) production and F-actin polyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d098cfe9ce6712307b25675ab3681418
https://doi.org/10.1182/blood.v101.3.1172
https://doi.org/10.1182/blood.v101.3.1172
Publikováno v:
Blood. 100:467-473
Erythroid colony formation in response to erythropoietin (EPO) stimulation is enhanced by costimulating the cells with prostaglandin-E2 (PGE2). The present study further analyzed the underlying mechanisms and demonstrated that EPO-mediated STAT5 tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3ae9b2585af54d006442246aabb28d
https://doi.org/10.1182/blood.v100.2.467
https://doi.org/10.1182/blood.v100.2.467
Autor:
Rüdiger Woscholski, Monique Plantavid, Christophe Erneux, Anneke Lyndsay Drayer, Hugues Chap, Bernard Payrastre, Sylvie Giuriato, Peter J. Parker
Publikováno v:
ResearcherID
The SH2 domain-containing inositol 5-phosphatase, SHIP, known to dephosphorylate inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate has recently been shown to be expressed in a variety of hemopoietic cells. This 145-kDa p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da82ca868b07fbddd738fb565b230da8
https://doi.org/10.1074/jbc.272.43.26857
https://doi.org/10.1074/jbc.272.43.26857