Zobrazeno 1 - 10
of 415
pro vyhledávání: '"A. Leslie Morrow"'
Autor:
Irina Balan, Adelina Grusca, Samantha Lucenell Chéry, Baylee R. Materia, Todd K. O’Buckley, A. Leslie Morrow
Publikováno v:
Life, Vol 14, Iss 7, p 860 (2024)
This study investigates the impact of allopregnanolone ([3α,5α]3-hydroxypregnan-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP); 10 mg/kg, IP) on fractalkine/CX3-C motif chemokine ligand 1 (CX3CL1) levels, associated signaling components, an
Externí odkaz:
https://doaj.org/article/6fa149dd1a5a44508eca65ad840ae1c9
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundPrevious studies demonstrated the inhibitory effect of allopregnanolone (3α,5α-THP) on the activation of inflammatory toll-like receptor 4 (TLR4) signals in RAW264.7 macrophages and the brains of selectively bred alcohol-preferring (P) ra
Externí odkaz:
https://doaj.org/article/a0903cfeb67f4ccfaf629de8acebf24e
Autor:
Irina Balan, Giorgia Boero, Samantha Lucenell Chéry, Minna H. McFarland, Alejandro G. Lopez, A. Leslie Morrow
Publikováno v:
Life, Vol 14, Iss 5, p 582 (2024)
Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors. Clinical studies
Externí odkaz:
https://doaj.org/article/fca29f2a91c74860ad3a637d1bf388ce
Autor:
Andrew M. Novick, Korrina A. Duffy, Rachel L. Johnson, Mary D. Sammel, Wen Cao, Andrew A. Strasser, Mehmet Sofuoglu, Alexandra Kuzma, James Loughead, A. Leslie Morrow, C. Neill Epperson
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-14 (2022)
Highlights Progesterone has sex-dependent effects on smoking measures in individuals with Tobacco Use Disorder. Higher conversion of progesterone to allopregnanolone (as indicated by the allopregnanolone:progesterone ratio) was associated with lower
Externí odkaz:
https://doaj.org/article/3e1906bc16fd4529a5d2f3a5e8ab85ce
Autor:
Irina Balan, Riah Patterson, Giorgia Boero, Holly Krohn, Todd K. O'Buckley, Samantha Meltzer-Brody, A. Leslie Morrow
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104473- (2023)
Summary: Background: Brexanolone has rapid, long-lasting, and remarkable efficacy in the treatment of post-partum depression (PPD). We test the hypothesis that brexanolone inhibits proinflammatory modulators and macrophage activation in PPD patients,
Externí odkaz:
https://doaj.org/article/a57fe11b9fed4ff19d4b847a48fb82ff
Autor:
Giorgia Boero, Minna H. McFarland, Ryan E. Tyler, Todd K. O’Buckley, Samantha L. Chéry, Donita L. Robinson, Joyce Besheer, A. Leslie Morrow
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1205 (2023)
The neurosteroid 3α,5α-THP is a potent GABAA receptor-positive modulator and its regulatory action on the HPA axis stress response has been reported in numerous preclinical and clinical studies. We previously demonstrated that 3α,5α-THP down-regu
Externí odkaz:
https://doaj.org/article/9939bdb810684702942edc51cb2b9101
Autor:
Irina Balan, Laure Aurelian, Kimberly S. Williams, Brian Campbell, Rick B. Meeker, A. Leslie Morrow
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We recently discovered that (3α,5α)3-hydroxypregnan-20-one (allopregnanolone) inhibits pro-inflammatory toll-like receptor (TLR) activation and cytokine/chemokine production in mouse macrophage RAW264.7 cells. The present studies evaluate neuroster
Externí odkaz:
https://doaj.org/article/44ed84a4e3a84904b61c24de85fc33d0
Autor:
Irina Balan, Laure Aurelian, Riana Schleicher, Giorgia Boero, Todd O’Buckley, A. Leslie Morrow
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract We have shown that endogenous neurosteroids, including pregnenolone and 3α,5α-THP inhibit toll-like receptor 4 (TLR4) signal activation in mouse macrophages and the brain of alcohol-preferring (P) rat, which exhibits innate TLR4 signal act
Externí odkaz:
https://doaj.org/article/bf981cc862c742bd85a7e2bd2d048b08
Autor:
Sung-Ho Lee, Margaret A. Broadwater, Woomi Ban, Tzu-Wen Winnie Wang, Hyeon-Joong Kim, Jaiden Seongmi Dumas, Ryan P. Vetreno, Melissa A. Herman, A. Leslie Morrow, Joyce Besheer, Thomas L. Kash, Charlotte A. Boettiger, Donita L. Robinson, Fulton T. Crews, Yen-Yu Ian Shih
Publikováno v:
NeuroImage, Vol 243, Iss , Pp 118541- (2021)
Resting-state functional magnetic resonance imaging (fMRI) has drastically expanded the scope of brain research by advancing our knowledge about the topologies, dynamics, and interspecies translatability of functional brain networks. Several database
Externí odkaz:
https://doaj.org/article/eb50d64d64ad42faa983f0c8ab2cf8b8
Autor:
Giorgia Boero, Ryan E. Tyler, Todd K. O’Buckley, Irina Balan, Joyce Besheer, A. Leslie Morrow
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1134 (2022)
Corticotropin-releasing factor (CRF) regulates the stress response in the hypothalamus and modulates neurotransmission across the brain through CRF receptors. Acute stress increases hypothalamic CRF and the GABAergic neurosteroid (3α,5α)3-hydroxypr
Externí odkaz:
https://doaj.org/article/ffe3e9d01b1042249ce28d3a5700d719