Zobrazeno 1 - 10
of 137
pro vyhledávání: '"A. L. Perrier"'
Autor:
Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106703- (2024)
Externí odkaz:
https://doaj.org/article/9b7b2a86457a4b27aeb7d79b1e947592
Autor:
Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106630- (2024)
Despite growing descriptions of wild-type Huntingtin (wt-HTT) roles in both adult brain function and, more recently, development, several clinical trials are exploring HTT-lowering approaches that target both wt-HTT and the mutant isoform (mut-HTT) r
Externí odkaz:
https://doaj.org/article/014f66c687ef4b789460f73ea00cc84e
Autor:
Romina Aron Badin, Aurore Bugi, Susannah Williams, Marta Vadori, Marie Michael, Caroline Jan, Alberto Nassi, Sophie Lecourtois, Antoine Blancher, Emanuele Cozzi, Philippe Hantraye, Anselme L. Perrier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Matching iPSC donors’ and patients’ HLA haplotypes has been proposed as a way to generate cell therapy products with enhanced immunological compatibility. Here the authors show that MHC matching alone is insufficient to grant long-term survival o
Externí odkaz:
https://doaj.org/article/c38f707228a749deb5410c466af92cb5
Autor:
Marija Fjodorova, Morgane Louessard, Zongze Li, Daniel C. De La Fuente, Emma Dyke, Simon P. Brooks, Anselme L. Perrier, Meng Li
Publikováno v:
Stem Cell Reports, Vol 13, Iss 3, Pp 448-457 (2019)
Summary: The mechanisms underlying the selective degeneration of medium spiny neurons (MSNs) in Huntington disease (HD) remain largely unknown. CTIP2, a transcription factor expressed by all MSNs, is implicated in HD pathogenesis because of its inter
Externí odkaz:
https://doaj.org/article/951ad28726b04624b556ebadd2e08d26
Autor:
Simona Gribaudo, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier
Publikováno v:
Stem Cell Reports, Vol 12, Iss 2, Pp 230-244 (2019)
Summary: Reappraisal of neuropathological studies suggests that pathological hallmarks of Alzheimer’s disease and Parkinson’s disease (PD) spread progressively along predictable neuronal pathways in the human brain through unknown mechanisms. Alt
Externí odkaz:
https://doaj.org/article/78075f0f658f496daa415520c4690dc1
Publikováno v:
Sciences, Eaux & Territoires, Iss Cahier spécial V (2021)
Depuis de nombreuses années, les territoires ont subi des aménagements fonciers ayant pour but de favoriser la productivité agricole, parfois au détriment de l'environnement, en particulier en contexte de grandes cultures. Les milieux aquatiques
Externí odkaz:
https://doaj.org/article/34c28039edb44b1b8eba337f7a94fe68
Autor:
Sylvain Perriot, Amandine Mathias, Guillaume Perriard, Mathieu Canales, Nils Jonkmans, Nicolas Merienne, Cécile Meunier, Lina El Kassar, Anselme L. Perrier, David-Axel Laplaud, Myriam Schluep, Nicole Déglon, Renaud Du Pasquier
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1199-1210 (2018)
Summary: Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases, interacting closely with other CNS cells but also with the immune system. However, due to the difficulty in obtaining human astrocytes, their role in thes
Externí odkaz:
https://doaj.org/article/4835770e4d1c4fb88ad494f4e27a421a
Autor:
Sophie Domingues, Yolande Masson, Aurore Marteyn, Jennifer Allouche, Anselme L. Perrier, Marc Peschanski, Cecile Martinat, Christine Baldeschi, Gilles Lemaître
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-7 (2017)
Abstract Background Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of the graft would be the major unmet deal in order to implement long-ter
Externí odkaz:
https://doaj.org/article/3ec13bd2c47742dcb992db00cb05683c
Autor:
Nicolas Merienne, Gabriel Vachey, Lucie de Longprez, Cécile Meunier, Virginie Zimmer, Guillaume Perriard, Mathieu Canales, Amandine Mathias, Lucas Herrgott, Tim Beltraminelli, Axelle Maulet, Thomas Dequesne, Catherine Pythoud, Maria Rey, Luc Pellerin, Emmanuel Brouillet, Anselme L. Perrier, Renaud du Pasquier, Nicole Déglon
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2980-2991 (2017)
Neurodegenerative disorders are a major public health problem because of the high frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders. We designed the
Externí odkaz:
https://doaj.org/article/c95c2641b9a34acb9503af6deab5c2eb
Autor:
Karine Cambon, Virginie Zimmer, Sylvain Martineau, Marie-Claude Gaillard, Margot Jarrige, Aurore Bugi, Jana Miniarikova, Maria Rey, Raymonde Hassig, Noelle Dufour, Gwenaelle Auregan, Philippe Hantraye, Anselme L. Perrier, Nicole Déglon
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 259-276 (2017)
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder resulting from a polyglutamine expansion in the huntingtin (HTT) protein. There is currently no cure for this disease, but recent studies suggest that RNAi to downregulat
Externí odkaz:
https://doaj.org/article/71c5f578d4f54a23910b98c544f67309