Výsledky vyhledávání - "A. L. Parnas"

Chiral N,N-Disubstituted Trifluoro-3-Amino-2-Propanols Are Potent Inhibitors of Cholesteryl Ester Transfer Protein

Publikováno v: Journal of Medicinal Chemistry. 45:3891-3904

A novel series of substituted N-benzyl-N-phenyl-trifluoro-3-amino-2-propanols are described that reversibly inhibit cholesteryl ester transfer protein (CETP). Starting with screening lead 22, various structural features were explored with respect to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054e4cc40c00d2928100cc032ffe6208
https://doi.org/10.1021/jm020038h

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Requirements-based monitors for real-time systems

Autor: Dennis K. Peters, David L. Parnas

Publikováno v: ACM SIGSOFT Software Engineering Notes. 25:77-85

Before designing safety- or mission-critical real-time systems, a specification of the required behaviour of the system should be produced and reviewed by domain experts. After the system has been implemented, it should be thoroughly tested to ensure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8916e9fa1ea64a1697b7205e190e5f7f
https://doi.org/10.1145/347636.348874

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Preface

Autor: Wolfram Kahl, David L. Parnas, Gunther Schmidt

Publikováno v: Electronic Notes in Theoretical Computer Science. 44(3):221-223

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7664b62aaf5e88a3f93b6273c7215045

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Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2

Autor: Barry L. Parnas, Randy H. Weiss, Richard W. Gross, Stanley L. Hazen, Daniel P. Getman, Karl W. Aston, Patrick J. Lennon, Lori A. Zupan

Publikováno v: Journal of Medicinal Chemistry. 36:95-100

Haloenol lactones are potent mechanism-based inhibitors of a novel class of calcium-independent phospholipases A2 which have been implicated as the enzymic mediators of membrane dysfunction during myocardial ischemia (Hazen, S. L.; et al. J. Biol. Ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e397d9026a25039dc79e818e404d01aa
https://doi.org/10.1021/jm00053a012

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Synthesis of high specific activity tritium labeled (E)-6-(bromomethylene)-tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one as a selective probe for calcium-independent phospholipase a2

Autor: Barry L. Parnas, Randy H. Weiss, Richard C. Durley

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 31:685-691

The synthesis of (E)-6-(bromomethylene)-tetrahydro-3-([4-3H]-1-naphthalenyl)-2H-pyran-2-one at a specific activity of 24.0 Ci/mmol is described. This probe was synthesized to determine whether (E)-6-(bromomethylene)-tetrahydro-3-(1-naphthalenyl)-2H-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::980d212138be9588192a4f41309d1862
https://doi.org/10.1002/jlcr.2580310907

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Application of parallel gradient high performance liquid chromatography with ultra-violet, evaporative light scattering and electrospray mass spectrometric detection for the quantitative quality control of the compound file to support pharmaceutical discovery

Autor: Adrian G Wright, Peter Waghorn, Anthony W. Squibb, Barry L. Parnas, Mark R. Taylor, Gareth P. Williams, Frank S. Pullen, Richard Girdler

Publikováno v: Journal of chromatography. A. 1189(1-2)

The success of drug discovery assays, using plate-based technologies, relies heavily on the quality of the substrates being tested. Sample purity, identity and concentration must be assured for a screening hit to be validated. Most major pharmaceutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2153ab9c7ccb5efa01ab97f1a7930cc9
https://pubmed.ncbi.nlm.nih.gov/18061198

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