Zobrazeno 1 - 10
of 19
pro vyhledávání: '"A. L. Oza"'
Autor:
Ker Boyce, Robert J. Graumann, Russell Reeves, Ashish L. Oza, John P. Payne, Shephal K. Doshi, Michael D. Pittaro, Jesus E. Val-Mejias, Mark W. Kroll
Publikováno v:
Pacing and Clinical Electrophysiology. 35:1253-1261
Background: The efficacy of tuned defibrillation waveforms versus the nominal fixed-tilt waveform has been previously studied. However, the optimal membrane time constant for tuning was not known. The POWER (Pulsewidth Optimized Waveform Evaluation t
Autor:
R. Allam, W. Galal, H. El-Damnhoury, A. Mortada, R. Guo, F. Fang, J. M. Xie, Q. Zhang, Y. S. Chan, W. H. Fung, O. Razali, H. Azlan, K. H. Lam, C. K. Chan, C. M. Yu, F. M. F. Wong, J. W. H. Sit, E. M. L. Wong, V. Lee, H. Hemingway, R. Harb, T. Crake, P. Lambiase, Q. Y. Zhao, S. B. Yu, H. Huang, M. Qin, H. Y. Cui, T. Huang, C. X. Huang, Y. W. Leung, C. S. Yue, K. F. Leung, C. Y. R. Fung, Y. M. W. Mak, K. S. Chow, S. K. Tang, J. Sperzel, K. Tscheliessnigg, J. J. J. Bucx, J. Silvestre, A. L. Oza, N. Yu Mironov, S. P. Golitsyn, S. F. Sokolov, Y. A. Yuricheva, E. B. Maikov, N. B. Shlevkov, Y. V. Mareev, L. V. Rosenstraukh, E. I. Chazov, B. N. Li, J. Qin, K. Xiang, W. M. Pang, L. S. Wang, H. S. Wu, T. T. Wong, P. A. Heng, J. Clatot, A. Ziyadeh-Isleem, A. Coulombe, S. Maugenre, G. Dilanian, S. Hatem, I. Denjoy, N. Neyroud, P. Guicheney, G. B. Plameras, M. V. Valentin, M. Ramirez, C. Suga, T. Hirahara, Y. Sugawara, J. Nakajima, H. Wakaba, J. Ako, S. Momomura, D. Ye Volkov, Y. I. Karpenko, D. A. Lopin, S. Y. Chair, J. C. K. Lee, K. C. Choi, E. M. Wong, C. W. H. Chan, W. K. W. So, A. H. Y. Cheng, A. K. Hamid, J. G. Lainchbury, R. W. Troughton, T. G. Yandle, C. M. Frampton, A. M. Richards
Publikováno v:
European Heart Journal Supplements. 14:A7-A11
Autor:
Paul G. Wyatt, Alan H. Fairlamb, Julie A. Frearson, Sandra L. Oza, Stephen Thompson, Daniel Spinks, Susan Wyllie, Justin R. Harrison, Leah S. Torrie, Ian H. Gilbert
Publikováno v:
Journal of Biological Chemistry. 284:36137-36145
In the search for new therapeutics for the treatment of human African trypanosomiasis, many potential drug targets in Trypanosoma brucei have been validated by genetic means, but very few have been chemically validated. Trypanothione synthetase (TryS
Publikováno v:
FEBS Journal. 275:5408-5421
Glutathionylspermidine is an intermediate formed in the biosynthesis of trypanothione, an essential metabolite in defence against chemical and oxidative stress in the Kinetoplastida. The kinetic mechanism for glutathionylspermidine synthetase (EC 6.3
Publikováno v:
The Journal of Biological Chemistry
The bifunctional trypanothione synthetase-amidase catalyzes biosynthesis and hydrolysis of the glutathione-spermidine adduct trypanothione, the principal intracellular thiol-redox metabolite in parasitic trypanosomatids. These parasites are unique wi
Publikováno v:
Molecular and Biochemical Parasitology. 149:117-120
Trypanothione synthetase (TryS) is a protein unique to the Kinetoplastida and has been shown to be essential in Trypanosoma brucei by RNAi techniques [1,2]. TryS is the sole enzyme responsible for the biosynthesis of trypanothione in the human pathog
Publikováno v:
Biochemical Journal. 391:425-432
Trypanothione plays a pivotal role in defence against chemical and oxidant stress, thiol redox homoeostasis, ribonucleotide metabolism and drug resistance in parasitic kinetoplastids. In Trypanosoma brucei, trypanothione is synthesized from glutathio
Autor:
Shephal K, Doshi, Michael D, Pittaro, Russell, Reeves, Ker, Boyce, John P, Payne, Mark W, Kroll, Robert J, Graumann, Ashish L, Oza, Jesus E, Val-Mejias
Publikováno v:
Pacing and clinical electrophysiology : PACE. 35(10)
The efficacy of tuned defibrillation waveforms versus the nominal fixed-tilt waveform has been previously studied. However, the optimal membrane time constant for tuning was not known. The POWER (Pulsewidth Optimized Waveform Evaluation tRial) trial
Autor:
Alan H. Fairlamb, Sandra L. Oza, Antoaneta Y. Sokolova, Stephen Patterson, Kevin D. Read, Susan Wyllie
Publikováno v:
Antimicrobial agents and chemotherapy. 54(7)
The protozoan parasites Trypanosoma brucei gambiense and T. b. rhodesiense are the causative agents of human African trypanosomiasis (HAT), commonly known as sleeping sickness. This epidemic disease was largely under control in the 1960s but has reem
Publikováno v:
Molecular and Biochemical Parasitology
As part of a drug discovery programme to discover new treatments for human African trypanosomiasis, recombinant trypanothione reductase from Trypanosoma brucei has been expressed, purified and characterized. The crystal structure was solved by molecu