Zobrazeno 1 - 10
of 389
pro vyhledávání: '"A. L. Oberg"'
Autor:
Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xianon Hou, Paula A. Schneider, Annabella R. Strathman, Karen S. Flatten, Chance C. Sine, Emily A. Balczewski, Cordelia D. McGehee, Melissa C. Larson, Laura N. Duffield, X. Wei Meng, Nicole D. Vincelette, Husheng Ding, Ann L. Oberg, Fergus J. Couch, Elizabeth M. Swisher, Hu Li, S. John Weroha, Scott H. Kaufmann
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid tumors, including platinum-resistant high grade serous ovarian cancer (HGSOC). Howev
Externí odkaz:
https://doaj.org/article/10416db1db3e4dd388e15b58bcaf44a8
Autor:
Abigail E. Asangba, Jun Chen, Krista M. Goergen, Melissa C. Larson, Ann L. Oberg, Jvan Casarin, Francesco Multinu, Scott H. Kaufmann, Andrea Mariani, Nicholas Chia, Marina R. S. Walther-Antonio
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Ovarian cancer (OC) is the second most common gynecological malignancy and the fifth leading cause of death due to cancer in women in the United States mainly due to the late-stage diagnosis of this cancer. It is, therefore, critical to iden
Externí odkaz:
https://doaj.org/article/c7bfec31158d4008840d29b28ac570cc
Autor:
Sierra Nguyen, Heather Carlson, Andrea Yoder, William R. Bamlet, Ann L. Oberg, Gloria M. Petersen, Steven G. Carmella, Stephen S. Hecht, Rick J. Jansen
Publikováno v:
Nutrients, Vol 16, Iss 5, p 688 (2024)
Exposure to polycyclic aromatic hydrocarbons (PAHs), byproducts of incomplete combustion, and their effects on the development of cancer are still being evaluated. Recent studies have analyzed the relationship between PAHs and tobacco or dietary inta
Externí odkaz:
https://doaj.org/article/79386e82be8f4ce0ad183e1a58a49d55
Autor:
Shounak Majumder, Thorvardur R. Halfdanarson, Calise K. Berger, Patrick H. Foote, Xiaoming Cao, Maria C. McGlinch, Brianna J. Gysbers, Jaime de La Fuente, Mariah J. Robran, Karen A. Doering, Kelli N. Burger, William E. Bamlet, Ann L. Oberg, Douglas W. Mahoney, Rondell P. Graham, William R. Taylor, Gloria M. Petersen, John B. Kisiel
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 3, Pp 409-416 (2022)
Background and Aims: Methylated DNA markers (MDMs) accurately identify several different cancer types, but there are limited data for pancreatic neuroendocrine tumors (pNETs). We aimed to identify MDM candidates in tissue that differentiate pNETs fro
Externí odkaz:
https://doaj.org/article/90339e48a18143f3be865fc2ccd81cc1
Autor:
Tara L. Hogenson, Hao Xie, William J. Phillips, Merih D. Toruner, Jenny J. Li, Isaac P. Horn, Devin J. Kennedy, Luciana L. Almada, David L. Marks, Ryan M. Carr, Murat Toruner, Ashley N. Sigafoos, Amanda N. Koenig-Kappes, Rachel L.O. Olson, Ezequiel J. Tolosa, Cheng Zhang, Hu Li, Jason D. Doles, Jonathan Bleeker, Michael T. Barrett, James H. Boyum, Benjamin R. Kipp, Amit Mahipal, Joleen M. Hubbard, Temperance J. Scheffler Hanson, Gloria M. Petersen, Surendra Dasari, Ann L. Oberg, Mark J. Truty, Rondell P. Graham, Michael J. Levy, Mojun Zhu, Daniel D. Billadeau, Alex A. Adjei, Nelson Dusetti, Juan L. Iovanna, Tanios S. Bekaii-Saab, Wen Wee Ma, Martin E. Fernandez-Zapico
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
BACKGROUND A patient-derived organoid (PDO) platform may serve as a promising tool for translational cancer research. In this study, we evaluated PDO’s ability to predict clinical response to gastrointestinal (GI) cancers.METHODS We generated PDOs
Externí odkaz:
https://doaj.org/article/f973dfbdbe53458f81a1c8da0742e768
Autor:
Upasana Ray, Debarshi Roy, Ling Jin, Prabhu Thirusangu, Julie Staub, Yinan Xiao, Eleftheria Kalogera, Andrea E. Wahner Hendrickson, Grace D. Cullen, Krista Goergen, Ann L. Oberg, Viji Shridhar
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Abstract Background Aberrant lipogenicity and deregulated autophagy are common in most advanced human cancer and therapeutic strategies to exploit these pathways are currently under consideration. Group III Phospholipase A2 (sPLA2-III/PLA2G3), an aty
Externí odkaz:
https://doaj.org/article/c51f205913f048ecae91afeecbaec90f
Autor:
Max J. Cotler, Khalil B. Ramadi, Xiaonan Hou, Elena Christodoulopoulos, Sebastian Ahn, Ashvin Bashyam, Huiming Ding, Melissa Larson, Ann L. Oberg, Charles Whittaker, Oliver Jonas, Scott H. Kaufmann, S. John Weroha, Michael J. Cima
Publikováno v:
Translational Oncology, Vol 21, Iss , Pp 101427- (2022)
Long-term treatment outcomes for patients with high grade ovarian cancers have not changed despite innovations in therapies. There is no recommended assay for predicting patient response to second-line therapy, thus clinicians must make treatment dec
Externí odkaz:
https://doaj.org/article/c99a7e1699694096a41da7ceb49b727a
Autor:
Ann L. Oberg, Ethan P. Heinzen, Xiaonan Hou, Mariam M. Al Hilli, Rachel M. Hurley, Andrea E. Wahner Hendrickson, Krista M. Goergen, Melissa C. Larson, Marc A. Becker, Jeanette E. Eckel-Passow, Matthew J. Maurer, Scott H. Kaufmann, Paul Haluska, S. John Weroha
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Repeated measures studies are frequently performed in patient-derived xenograft (PDX) models to evaluate drug activity or compare effectiveness of cancer treatment regimens. Linear mixed effects regression models were used to perform statist
Externí odkaz:
https://doaj.org/article/ff6b9ed53489469fac350642c746a06e
Autor:
Arun Kanakkanthara, Catherine J. Huntoon, Xiaonan Hou, Minzhi Zhang, Ethan P. Heinzen, Daniel R. O’Brien, Ann L. Oberg, S. John Weroha, Scott H. Kaufmann, Larry M. Karnitz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
High-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and in
Externí odkaz:
https://doaj.org/article/cd553ee268364657964406f6c999755e
Publikováno v:
Journal of Thoracic Oncology. 18:143-157
Next-generation sequencing (NGS) technologies are high-throughput methods for DNA sequencing and have become a widely adopted tool in cancer research. The sheer amount and variety of data generated by NGS assays require sophisticated computational me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f941c60d7bf51fefc65bf99135275d08
https://doi.org/10.1016/j.jtho.2022.11.006
https://doi.org/10.1016/j.jtho.2022.11.006