Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)Summary

Autor: Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi, Ian Arnott, Aiden Cahill, Malcolm Smith, Tariq Ahmad, Sreedhar Subramanian, Simon Travis, John Morris, John Hamlin, Anjan Dhar, Chuka Nwokolo, Cathryn Edwards, Tom Creed, Stuart Bloom, Mohamed Yousif, Linzi Thomas, Simon Campbell, Stephen J. Lewis, Shaji Sebastian, Sandip Sen, Simon Lal, Chris Hawkey, Charles Murray, Fraser Cummings, Jason Goh, James O. Lindsay, Naila Arebi, Lindsay Potts, Aileen J. McKinley, John M. Thomson, John A. Todd, Mhairi Collie, Ashley Mowat, Daniel R. Gaya, Jack Winter, Graham D. Naismith, Catriona Keerie, Steff Lewis, Robin J. Prescott, Gordan Lauc, Harry Campbell, Dermot P.B. McGovern, Vito Annese, Vlatka Zoldoš, Iain K. Permberton, Manfred Wuhrer, Daniel Kolarich, Daryl L. Fernandes, Evropi Theorodorou, Victoria Merrick Daniel I. Spencer, Richard A. Gardner, Ray Doran, Archana Shubhakar, Ray Boyapati, Igor Rudan, Paolo Lionetti, Irena Trbojević Akmačić, Jasminka Krištić, Frano Vuč ković, Jerko Štambuk, Mislav Novokmet, Maja Pučić-Baković, Olga Gornik, Angelo Andriulli, Laura Cantoro, Giancarlo Sturniolo, Gionata Fiorino, Natalia Manetti, Anna Latiano, Anna Kohn, Renata D’Inca`, Silvio Danese, Ian D. Arnott, Colin L. Noble, Charlie W. Lees, Alan G. Shand, Gwo-Tzer Ho, Lee Murphy, Jude Gibson, Louise Evenden, Nicola Wrobel, Tamara Gilchrist, Angie Fawkes, Guinevere S.M. Kammeijer, Florent Clerc, Noortje de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, Paula Dobrinić, Yurii Aulchenko, Tim van den Heuve, Daisy Jonkers, Marieke Pierik

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 431-450 (2023)

Background & Aims: DNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA me

Externí odkaz: https://doaj.org/article/f32b67ecfa854c6487a3c5196a5070e3

Ultrasound-mediated gene delivery of factor VIII plasmids for hemophilia A gene therapy in mice

Autor: Shuxian Song, Meghan J. Lyle, Misty L. Noble-Vranish, Dominic M. Min-Tran, James Harrang, Weidong Xiao, Evan C. Unger, Carol H. Miao

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 916-926 (2022)

Gene therapy offers great promises for a cure of hemophilia A resulting from factor VIII (FVIII) gene deficiency. We have developed and optimized a non-viral ultrasound-mediated gene delivery (UMGD) strategy. UMGD of reporter plasmids targeting mice

Externí odkaz: https://doaj.org/article/b94d4d026cfa4bb19aa9f92a3a0f7cef

Scratching the Surface: A Marine Sediment Provenance Record From the Continental Slope of Central Wilkes Land, East Antarctica

Autor: Sian Tooze, Jacqueline A. Halpin, Taryn L. Noble, Zanna Chase, Philip E. O'Brien, Leanne Armand

Publikováno v: Geochemistry, Geophysics, Geosystems, Vol 21, Iss 11, Pp n/a-n/a (2020)

Abstract The geology of Wilkes Land, East Antarctica, is masked by kilometers of ice and remains largely unexplored. Defining the sediment provenance adjacent to this hidden region is important for distinguishing the proximal subglacial basement terr

Externí odkaz: https://doaj.org/article/19454053bb144ff883b8211ee163effc

Ultrasound-Mediated Gene Therapy in Swine Livers Using Single-Element, Multi-lensed, High-Intensity Ultrasound Transducers

Autor: Misty L. Noble-Vranish, Shuxian Song, Kyle P. Morrison, Dominic M. Tran, Ryan R. Sun, Keith R. Loeb, George W. Keilman, Carol H. Miao

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 179-188 (2018)

We have achieved significant enhancement of gene delivery into livers of large animals using ultrasound (US)-targeted microbubble (MB) destruction methods. An infusion of pGL4 (encoding a luciferase reporter gene) plasmid DNA (pDNA) and MBs into a po

Externí odkaz: https://doaj.org/article/411c2bb3bde8429ab04f2514882c96b9

From the Surface Ocean to the Seafloor: Linking Modern and Paleo‐Genetics at the Sabrina Coast, East Antarctica (IN2017_V01)

Autor: Linda Armbrecht, Amaranta Focardi, Kelly‐Anne Lawler, Phil O’Brien, Amy Leventer, Taryn L. Noble, Bradley Opdyke, Meghan Duffy, Dimitris Evangelinos, Simon C. George, Jan Lieser, Adrián López‐Quirós, Alix Post, Martin Ostrowski, Ian Paulsen, Leanne Armand

Publikováno v: Journal of Geophysical Research: Biogeosciences. 128

This project was supported through funding from the Australian Government’s Australian Antarctic Science Grant Programs (AAS 4333 and AAS 4419) and the Australian Research Council’s Discovery Projects funding scheme (DP170100557). We thank the te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c893b031dffd88fadc04e6357913abd
https://doi.org/10.1029/2022jg007252