Zobrazeno 1 - 10
of 44
pro vyhledávání: '"A. L. Nikkel"'
Autor:
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
Publikováno v:
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://doaj.org/article/7ff3f238f99040afb97c2dc3b9419d6e
Autor:
Arthur L. Nikkel, Marian T. Namovic, D. L. Widomski, Diana L. Donnelly-Roberts, Steve McGaraughty, Zhi Su, Laura Leys, Murali Gopalakrishnan
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 29:281-290
Background:Losartan, a blocker of the angiotensin II type I receptor, is an important part of the standard of care for diabetic nephropathy (DN). The obese ZSF-1 rats display many aspects of the clinical features of human Type II DN. The current stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ee6718b0617d47fc87a9b5095eb0e3
https://doi.org/10.1515/jbcpp-2017-0157
https://doi.org/10.1515/jbcpp-2017-0157
Autor:
Arthur L. Nikkel, Stella Markosyan, Michael F. Jarvis, Katharine L. Chu, Jill-Desiree Brederson, Robert S. Bitner, Rebecca M. Edelmayer, Steve McGaraughty, Jun Xu
Publikováno v:
Journal of Orthopaedic Research®. 36:2109-2117
Osteoarthritis (OA) is a degenerative form of arthritis that can result in loss of joint function and chronic pain. The pathological pain state that develops with OA disease involves plastic changes in the peripheral and central nervous systems, howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa2f03d418732f3471116d24283369f
https://doi.org/10.1002/jor.23869
https://doi.org/10.1002/jor.23869
Autor:
Anthony M. Giamis, Andrew Goodearl, Christine Grinnell, Kelly J. Doyle, Katherine Salte, Victor Sun, Todd B. Cole, Murali Gopalakrishnan, L. Olson, Susan E. Lacy, Meha Chhaya, Yanping Luo, Steve McGaraughty, Arthur L. Nikkel, Rachel Davis-Taber, Chang Z. Zhu, Gregory M. Preston
Publikováno v:
Journal of the American Society of Nephrology. 28:3616-3626
Targeted delivery of a therapeutic agent to a site of pathology to ameliorate disease while limiting exposure at undesired tissues is an aspirational treatment scenario. Targeting diseased kidneys for pharmacologic treatment has had limited success.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659c791d91484f4775bf1a55608ce936
https://doi.org/10.1681/asn.2017010013
https://doi.org/10.1681/asn.2017010013
Autor:
Nicole V Haste, Diana Donnelly-Roberts, Swathi Krishnan, Lauren LeBon, Jennifer M. Frost, Fiona E. McAllister, Andrea T. Ireland, Yao Liang Wong, Carmela Sidrauski, Stephan Riedmaier, Michael J. Dart, Kathy L. Kohlhaas, Lei Shi, Nimrod D. Rubinstein, Ana M. Basso, Janani Prakash, Kathleen A. Martin, Andrew M. Swensen, Arthur L. Nikkel, Jonathon J. O’Brien, Margaret Ann Roy, Holly M. Robb
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9990114b53b75c88cb58914a496683c
https://doi.org/10.7554/elife.42940
https://doi.org/10.7554/elife.42940
Autor:
Diana L. Donnelly-Roberts, Ana M. Basso, Arthur L. Nikkel, Andrea T. Ireland, Jennifer M. Frost, Lauren LeBon, Carmela Sidrauski, Stephan Riedmaier, Nimrod D. Rubinstein, Holly M. Robb, Kathleen A. Martin, Nicole V Haste, Fiona E. McAllister, Swathi Krishnan, Lei Shi, Margaret Ann Roy, Andrew M. Swensen, Janani Prakash, Jonathon J. O’Brien, Kathy L. Kohlhaas, Yao Liang Wong, Michael J. Dart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ebd2110389786065142053652d6bb1f
https://doi.org/10.7554/elife.42940.036
https://doi.org/10.7554/elife.42940.036
Autor:
Arthur L. Nikkel, Ji Ma, L. Olson, Sujatha M. Gopalakrishnan, Kelly J. Doyle, Vivek C. Abraham, D. L. Widomski, Steve McGaraughty, Brent Putman, Murali Gopalakrishnan, Laura Leys, Chang Z. Zhu, Steve D. Pratt, Zhi Su, Chih-Hung Lee, K. Salte
Publikováno v:
European Journal of Pharmacology. 788:1-11
Adenosine (ADO) is an important regulatory purine nucleoside that accumulates at sites of inflammation and tissue injury including in diseases associated with renal pathology. Endogenous levels of ADO may be increased by inhibiting the ADO-metabolizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb16781e9a82796fc5637e8ffccc0b2
https://doi.org/10.1016/j.ejphar.2016.06.012
https://doi.org/10.1016/j.ejphar.2016.06.012
Autor:
Ana M. Basso, Nimrod D. Rubinstein, Arthur L. Nikkel, Fiona E. McAllister, Jennifer M. Frost, Michael J. Dart, Janani Prakash, Diana Donnelly-Roberts, Kathleen A. Martin, Kathy L. Kohlhaas, Andrew M. Swensen, Lauren LeBon, Lei Shi, Jonathon J. O’Brien, Yao Liang Wong, Stephan Riedmaier, Swathi Krishnan, Nicole V Haste, Carmela Sidrauski, Holly M. Robb
The Integrated Stress Response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792bd23e32b80b51dd87fa6b42310ee3
Autor:
Karen T. Kaye, Arthur L. Nikkel, Eric G. Mohler, Jordan W. Brown, Tammy L. Dellovade, Chang Z. Zhu, Holly M. Robb, Victoria A. Roderwald
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa7f145250bc591ba7efba26ec6819b
https://doi.org/10.1016/j.jalz.2018.06.136
https://doi.org/10.1016/j.jalz.2018.06.136
Autor:
Diana L. Donnelly-Roberts, Arthur L. Nikkel, Chang Z. Zhu, Steve McGaraughty, Kelly J. Doyle, Murali Gopalakrishnan, Marian T. Namovic, K. Salte, Lauren Olsen, D. L. Widomski, Zhi Su
Publikováno v:
Journal of pharmacological and toxicological methods. 94(Pt 1)
Introduction The adenine model of kidney disease typically involves dietary delivery of adenine over several weeks. This model can be variable in its disease progression and can result in significant mortality. In the current study, the amount of ade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e16bcc1990a1673c0f52adad06e199e
https://pubmed.ncbi.nlm.nih.gov/29684554
https://pubmed.ncbi.nlm.nih.gov/29684554