Dysregulation of platelet serotonin, 14–3–3, and GPIX in sudden infant death syndrome

Autor: Andrew L. Frelinger, Robin L. Haynes, Richard D. Goldstein, Michelle A. Berny-Lang, Anja J. Gerrits, Molly Riehs, Elisabeth A. Haas, Brankica Paunovic, Othon J. Mena, Steven C. Campman, Ginger L. Milne, Lynn A. Sleeper, Hannah C. Kinney, Alan D. Michelson

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Sudden infant death syndrome (SIDS) is the leading cause of post-neonatal infant mortality, but the underlying cause(s) are unclear. A subset of SIDS infants has abnormalities in the neurotransmitter, serotonin (5-hydroxytryptamine [5-HT]) a

Externí odkaz: https://doaj.org/article/3c59b8e94be64128b9d6845b97a05786

Blood-based DNA methylation markers for lung cancer prediction

Autor: Marc Chadeau-Hyam, Paolo Vineis, Caroline Relton, Mattias Johansson, Gianluca Severi, Roger L Milne, Melissa C Southey, Pierre-Antoine Dugué, Florence Guida, Mikael Johansson, Torkjel Sandanger, Justina Ucheojor Onwuka, Ryan Langdon, Therese Haugdahl Nøst, Hilary A. Robbins, Matthew Suderman

Publikováno v: BMJ Oncology, Vol 3, Iss 1 (2024)

Objective Screening high-risk individuals with low-dose CT reduces mortality from lung cancer, but many lung cancers occur in individuals who are not eligible for screening. Risk biomarkers may be useful to refine risk models and improve screening el

Externí odkaz: https://doaj.org/article/31adadfff44f48119b68988cdec01203

An integrative multi-omics approach to characterize interactions between tuberculosis and diabetes mellitus

Autor: Caian L. Vinhaes, Eduardo R. Fukutani, Gabriel C. Santana, María B. Arriaga, Beatriz Barreto-Duarte, Mariana Araújo-Pereira, Mateus Maggiti-Bezerril, Alice M.S. Andrade, Marina C. Figueiredo, Ginger L. Milne, Valeria C. Rolla, Afrânio L. Kristki, Marcelo Cordeiro-Santos, Timothy R. Sterling, Bruno B. Andrade, Artur T.L. Queiroz

Publikováno v: iScience, Vol 27, Iss 3, Pp 109135- (2024)

Summary: Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, a machine learning algorithm was applied to multi-platform data, including cytokines and gene expres

Externí odkaz: https://doaj.org/article/5f21262bf6024bae9b93b8627b42b9d7

The Effects of Aspirin Intervention on Inflammation-Associated Lingual Bacteria: A Pilot Study from a Randomized Clinical Trial

Autor: Guillaume C. Onyeaghala, Shweta Sharma, Mosunmoluwa Oyenuga, Christopher M. Staley, Ginger L. Milne, Ryan T. Demmer, Aasma Shaukat, Bharat Thyagarajan, Robert J. Straka, Timothy R. Church, Anna E. Prizment

Publikováno v: Microorganisms, Vol 12, Iss 8, p 1609 (2024)

Several bacterial taxa enriched in inflammatory bowel diseases and colorectal cancer (CRC) are found in the oral cavity. We conducted a pilot study nested within a six-week aspirin intervention in a randomized placebo-controlled trial to test their r

Externí odkaz: https://doaj.org/article/e1b10069edd9494f97c74d46c12cfbff

A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

Autor: Pooja Middha, Xiaoliang Wang, Sabine Behrens, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Thaïs Baert, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Javier Benitez, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Daniele Campa, Federico Canzian, Angel Carracedo, Jose E. Castelao, Stephen J. Chanock, Georgia Chenevix-Trench, CTS Consortium, Emilie Cordina-Duverger, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Laure Dossus, Pierre-Antoine Dugué, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Olivia Fletcher, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Graham G. Giles, Anna González-Neira, Felix Grassmann, Anne Grundy, Pascal Guénel, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Susan E. Hankinson, Elaine F. Harkness, Bernd Holleczek, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Christian Ingvar, ABCTB Investigators, kConFab Investigators, Karolin Isaksson, Helena Jernström, Esther M. John, Michael E. Jones, Rudolf Kaaks, Renske Keeman, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Nicole L. Larson, Susanna Larsson, Loic Le Marchand, Flavio Lejbkowicz, Shuai Li, Martha Linet, Jolanta Lissowska, Maria Elena Martinez, Tabea Maurer, Anna Marie Mulligan, Claire Mulot, Rachel A. Murphy, William G. Newman, Sune F. Nielsen, Børge G. Nordestgaard, Aaron Norman, Katie M. O’Brien, Janet E. Olson, Alpa V. Patel, Ross Prentice, Erika Rees-Punia, Gad Rennert, Valerie Rhenius, Kathryn J. Ruddy, Dale P. Sandler, Christopher G. Scott, Mitul Shah, Xiao-Ou Shu, Ann Smeets, Melissa C. Southey, Jennifer Stone, Rulla M. Tamimi, Jack A. Taylor, Lauren R. Teras, Katarzyna Tomczyk, Melissa A. Troester, Thérèse Truong, Celine M. Vachon, Sophia S. Wang, Clarice R. Weinberg, Hans Wildiers, Walter Willett, Stacey J. Winham, Alicja Wolk, Xiaohong R. Yang, M. Pilar Zamora, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul D. P. Pharoah, Montserrat García-Closas, Marjanka K. Schmidt, Peter Kraft, Roger L. Milne, Sara Lindström, Douglas F. Easton, Jenny Chang-Claude

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-13 (2023)

Abstract Background Genome-wide studies of gene–environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million comm

Externí odkaz: https://doaj.org/article/6c79833d7bd146bb9546b870710a3333