Zobrazeno 1 - 9
of 9
pro vyhledávání: '"A. L. Mazzu"'
Autor:
Wolfgang Mück, Reiner Frey, Christian Scheerans, Arthur L. Mazzu, Martin Blunck, Pavur R. Sundaresan, John Lettieri
Publikováno v:
The Journal of Clinical Pharmacology. 52:1240-1247
This open-label, parallel-group, single-dose study assessed the safety and pharmacokinetics of cinaciguat, a novel soluble guanylate cyclase activator in clinical development for the treatment of acute decompensated heart failure, in individuals with
Autor:
Leonard Joseph Appleman, Arthur L. Mazzu, Pavur R. Sundaresan, Alain C. Mita, Geoffrey I. Shapiro, Frank Cihon, Anthony W. Tolcher
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose To characterize the cardiovascular profile of sorafenib, a multitargeted kinase inhibitor, in patients with advanced cancer. Methods Fifty-three patients with advanced cancer received oral sorafenib 400 mg bid in continuous 28-day cycles in t
Publikováno v:
Journal of Clinical Oncology. 29:2580-2580
2580 Background: This study was undertaken to examine the influence of mild/moderate hepatic impairment on the safety and pharmacokinetic (PK) profile of sorafenib in non-cancer subjects. Methods: ...
Publikováno v:
American journal of hypertension. 5(12 Pt 1)
The effects of the calcium antagonist nitrendipine and the diuretic hydrochlorothiazide on plasma calciotropic hormone concentrations and lumbar bone density were compared during the treatment of hypertension in a randomized, double-blind, 8 week par
Autor:
Arthur L. Mazzu, G. Dennis Clifton, Mary H. H. Chandler, John T. Lettieri, Thomas S. Foster, Michael R. Harrison, Douglas R. Allington, Andrew C. Thieneman
Publikováno v:
Journal of clinical pharmacology. 32(6)
This randomized double-blind parallel group study characterized the pharmacokinetics of the calcium channel antagonist, nisoldipine (core-coat tablets), administered once daily for 7 days in doses of 5 mg (n = 12), 10 mg (n = 13), 20 mg (n = 12), and
Publikováno v:
The American journal of cardiology. 65(18)
We compared the effects of nitrendipine, a dihydropyridine calcium antagonist, with those of hydrochlorothiazide during treatment for approximately 1 year in 32 patients with mild or moderate systemic hypertension. To obtain comparable decrease in bl
Autor:
J. T. Lettieri, G. J. Krol, R. J. Taylor, D. E. Burkholder, A. L. Mazzu, C. Bon, J. P. Birkett
Publikováno v:
Journal of Cardiovascular Pharmacology. 9:S129-S135
Summary A five-way crossover study with 30 prescreened volunteers was performed to compare two dosage formulations of Miles nitrendipine tablets with corresponding Bayer A G tablet formulations. All tablet formulations were also compared with a 20 mg
Autor:
A. L. Mazzu, C. P. Smith
Publikováno v:
Journal of biomedical materials research. 18(8)
Polyurethanes are finding increasing utilization in biomedical applications. Recently, the reported finding of methylene dianiline (4,4'-diaminodiphenylmethane, MDA) in the aqueous extracts of autoclaved 4,4'-diphenylmethane diisocyanate-based polyur
Publikováno v:
HETEROCYCLES. 15:361