Zobrazeno 1 - 10
of 604
pro vyhledávání: '"A. L. Landay"'
Autor:
Preeti Moar, Scott Bowler, Alan L. Landay, Sara Gianella, Lishomwa C. Ndhlovu, Thomas A. Premeaux
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Despite the success in the management of HIV with antiretroviral therapy (ART), people with HIV (PWH) have a heightened state of immune activation and inflammation, and an estimated 10%–40% demonstrate poor CD4 T-cell reconstitution, there
Externí odkaz:
https://doaj.org/article/4a2052060491425ea306eee7f1bab276
Autor:
Kai Luo, Brandilyn A. Peters, Jee-Young Moon, Xiaonan Xue, Zheng Wang, Mykhaylo Usyk, David B. Hanna, Alan L. Landay, Michael F. Schneider, Deborah Gustafson, Kathleen M. Weber, Audrey French, Anjali Sharma, Kathryn Anastos, Tao Wang, Todd Brown, Clary B. Clish, Robert C. Kaplan, Rob Knight, Robert D. Burk, Qibin Qi
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Gut dysbiosis has been linked with both HIV infection and diabetes, but its interplay with metabolic and inflammatory responses in diabetes, particularly in the context of HIV infection, remains unclear. Methods We first conducted
Externí odkaz:
https://doaj.org/article/ddd735eae386481991401f432e4d62a0
Autor:
Leila B. Giron, Qin Liu, Opeyemi S. Adeniji, Xiangfan Yin, Toshitha Kannan, Jianyi Ding, David Y. Lu, Susan Langan, Jinbing Zhang, Joao L. L. C. Azevedo, Shuk Hang Li, Sergei Shalygin, Parastoo Azadi, David B. Hanna, Igho Ofotokun, Jason Lazar, Margaret A. Fischl, Sabina Haberlen, Bernard Macatangay, Adaora A. Adimora, Beth D. Jamieson, Charles Rinaldo, Daniel Merenstein, Nadia R. Roan, Olaf Kutsch, Stephen Gange, Steven M. Wolinsky, Mallory D. Witt, Wendy S. Post, Andrew Kossenkov, Alan L. Landay, Ian Frank, Phyllis C. Tien, Robert Gross, Todd T. Brown, Mohamed Abdel-Mohsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this
Externí odkaz:
https://doaj.org/article/834ccc7d78f64593bd700f4fd920f417
Autor:
Thomas A. Premeaux, Scott Bowler, Courtney M. Friday, Carlee B. Moser, Martin Hoenigl, Michael M. Lederman, Alan L. Landay, Sara Gianella, Lishomwa C. Ndhlovu
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109945- (2024)
Summary: Despite the success of antiretroviral therapy (ART), individuals with HIV remain at risk for experiencing non-AIDS adverse events (NAEs), including cardiovascular complications and malignancy. Several surrogate immune biomarkers in blood hav
Externí odkaz:
https://doaj.org/article/d190aea2d2ba4ccb8dda73df9260d004
Autor:
Shalini Singh, Leila B. Giron, Maliha W. Shaikh, Shivanjali Shankaran, Phillip A. Engen, Zlata R. Bogin, Simona A. Bambi, Aaron R. Goldman, Joao L. L. C. Azevedo, Lorena Orgaz, Nuria de Pedro, Patricia González, Martin Giera, Aswin Verhoeven, Elena Sánchez-López, Ivona Pandrea, Toshitha Kannan, Ceylan E. Tanes, Kyle Bittinger, Alan L. Landay, Michael J. Corley, Ali Keshavarzian, Mohamed Abdel-Mohsen
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-23 (2024)
Abstract Background People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial dysbiosis and transl
Externí odkaz:
https://doaj.org/article/03326450ced04999be69828f4f9541f9
Autor:
Zheng Wang, Brandilyn A. Peters, MacKenzie Bryant, David B. Hanna, Tara Schwartz, Tao Wang, Christopher C. Sollecito, Mykhaylo Usyk, Evan Grassi, Fanua Wiek, Lauren St. Peter, Wendy S. Post, Alan L. Landay, Howard N. Hodis, Kathleen M. Weber, Audrey French, Elizabeth T. Golub, Jason Lazar, Deborah Gustafson, Anjali Sharma, Kathryn Anastos, Clary B. Clish, Robert D. Burk, Robert C. Kaplan, Rob Knight, Qibin Qi
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Background Alterations in gut microbiota have been implicated in HIV infection and cardiovascular disease. However, how gut microbial alterations relate to host inflammation and metabolite profiles, and their relationships with atheroscleros
Externí odkaz:
https://doaj.org/article/da80297957c64761a09224215e94a1c0
Autor:
Jenifer Vallejo, Ryosuke Saigusa, Rishab Gulati, Sujit Silas Armstrong Suthahar, Vasantika Suryawanshi, Ahmad Alimadadi, Christopher P. Durant, Yanal Ghosheh, Payel Roy, Erik Ehinger, Tanyaporn Pattarabanjird, David B. Hanna, Alan L. Landay, Russell P. Tracy, Jason M. Lazar, Wendy J. Mack, Kathleen M. Weber, Adaora A. Adimora, Howard N. Hodis, Phyllis C. Tien, Igho Ofotokun, Sonya L. Heath, Avishai Shemesh, Coleen A. McNamara, Lewis L. Lanier, Catherine C. Hedrick, Robert C. Kaplan, Klaus Ley
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Cryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- and treatment-relevant data in clinical studies. Here, we developed combined protein (40 antibodies) and transcript single-cell
Externí odkaz:
https://doaj.org/article/02a45738c2a44c44b7e9d1b98a16d7b0
Autor:
Cristian Apetrei, Thaidra Gaufin, Egidio Brocca-Cofano, Ranjit Sivanandham, Paola Sette, Tianyu He, Sindhuja Sivanandham, Natalie Martinez Sosa, Kathryn J. Martin, Kevin D. Raehtz, Adam J. Kleinman, Audrey Valentine, Noah Krampe, Rajeev Gautam, Andrew A. Lackner, Alan L. Landay, Ruy M. Ribeiro, Ivona Pandrea
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Resolution of T cell activation and inflammation is a key determinant of the lack of SIV disease progression in African green monkeys (AGMs). Although frequently considered together, T cell activation occurs in response to viral stimulation of acquir
Externí odkaz:
https://doaj.org/article/f3187b8d640d4184b98561564f00b330
Autor:
Tomas Raul Wiche Salinas, Yuwei Zhang, Annie Gosselin, Natalia Fonseca Rosario, Mohamed El-Far, Ali Filali-Mouhim, Jean-Pierre Routy, Carl Chartrand-Lefebvre, Alan L. Landay, Madeleine Durand, Cécile L. Tremblay, Petronela Ancuta
Publikováno v:
Cells, Vol 13, Iss 2, p 157 (2024)
Cardiovascular disease (CVD) remains an important comorbidity in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Our previous studies performed in the Canadian HIV/Aging Cohort Study (CHACS) (>40 years-old; Framingham Risk Sco
Externí odkaz:
https://doaj.org/article/6e3d5b0e9ac945fea97b1abf8a1ce930
Autor:
Nuria Gallego Márquez, Armaan Jamal, Rowena Johnston, E India Richter, Pamina M Gorbach, Tracy D Vannorsdall, Leah H Rubin, Cheryl Jennings, Alan L Landay, Michael J Peluso, Annukka A R Antar
Publikováno v:
JMIR Research Protocols, Vol 12, p e47079 (2023)
BackgroundLiving with HIV is a risk factor for severe acute COVID-19, but it is unknown whether it is a risk factor for long COVID. ObjectiveThis study aims to characterize symptoms, sequelae, and cognition formally and prospectively 12 months follo
Externí odkaz:
https://doaj.org/article/6e90f619636246f7a5f3720a1ffb8e25