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Akademický článek

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Publikováno v: Open Biology, Vol 7, Iss 10 (2017)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3–5 years of diagnosis. Recently, we identified disease-linke

Externí odkaz: https://doaj.org/article/de64dd65912e44579c028274a46fd196

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Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Publikováno v: Cellular and Molecular Life Sciences. 75:335-354

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that have common molecular and pathogenic characteristics, such as aberrant accumulation and ubiquitylation of TDP-43; however, the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf250d9fd1f8a49e0587e6310ee11a3
https://doi.org/10.1007/s00018-017-2632-8

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A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease

Autor: Andrew P. Badrock, Emily K. Don, Isabel Formella, Thomas E. Hall, Nicholas J. Cole, Alison L. Hogan, Elinor Hortle, Serene S. L. Gwee, Sharron Chow, Jack J Stoddart, Marco Morsch, Roger S. Chung, Garth A. Nicholson

Publikováno v: Zebrafish. 14:69-72

Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd59877d187f021421bdbe27e87d9c96
https://doi.org/10.1089/zeb.2016.1321

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Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V

Publikováno v: Protein engineering, design & selection : PEDS, 32(10), 443-457. Oxford University Press

The accumulation of toxic protein aggregates is thought to play a key role in a range of degenerative pathologies, but it remains unclear why aggregation of polypeptides into non-native assemblies is toxic and why cellular clearance pathways offer in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5436fd137e8390bee55460977820cf
https://research.utwente.nl/en/publications/5d08f882-1c15-4b53-9004-7ca723b489d2

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Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype

Publikováno v: Human molecular genetics. 28(4)

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative disease characterised by the death of upper and lower motor neurons. Approximately 10% of cases have a known family history of ALS and disease-linked mutations in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0d38a5c647694e6e6c4878cd12c91a
https://pubmed.ncbi.nlm.nih.gov/28444311

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Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish

Autor: Adrian K. West, Nicholas J. Cole, Andrew P. Badrock, Sharron Chow, Emily K. Don, Marco Morsch, Monisha D. Syal, Roger S. Chung, Steve N. S. Cheung, Albert Lee, Rowan A. W. Radford, Isabel Formella, Serene S. L. Gwee

Publikováno v: Cellular and molecular life sciences : CMLS. 75(23)

Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in orchestrating cell division and cytokinesis, and is prominently expressed in healthy proliferating and cancerous cells. However, the role of AurkB in diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5426b80d06fe6af88c1f154a8e1ed3
https://pubmed.ncbi.nlm.nih.gov/29468257

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Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Publikováno v: Open Biology
Open Biology, Vol 7, Iss 10 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7fbfa53f37912d776e3e714c90cde8
http://europepmc.org/articles/PMC5666078

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Enhancement of Power System Transient Response by Control of HVDC Converter Power

Autor: C. L. Gwee, T. J. Hammons, P. A. Kacejko, R. L. Yeo

Publikováno v: Scopus-Elsevier

This paper examines enhancement of power system stability by control of real power which is injected into or taken from the AC system by the high-voltage direct current (HVDC) converter in transmission systems with HVDC transmission. It also investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc10ad0279e750ba3c03323e24c277a
https://doi.org/10.1080/073135600268342

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