Zobrazeno 1 - 10
of 1 809
pro vyhledávání: '"A. L. Gould"'
Autor:
Javier Encinar del Dedo, M. Belén Suárez, Rafael López-San Segundo, Alicia Vázquez-Bolado, Jingjing Sun, Natalia García-Blanco, Patricia García, Pauline Tricquet, Jun-Song Chen, Peter C. Dedon, Kathleen L. Gould, Elena Hidalgo, Damien Hermand, Sergio Moreno
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Quiescent cells require a continuous supply of proteins to maintain protein homeostasis. In fission yeast, entry into quiescence is triggered by nitrogen stress, leading to the inactivation of TORC1 and the activation of TORC2. In this study
Externí odkaz:
https://doaj.org/article/3119c497abcb4641aacf4684b00da464
Autor:
Monica Panca, Robert Howard, Elizabeth Cort, Charlotte Rawlinson, Rebecca L. Gould, Martin Wiegand, Anne Marie Downey, Sube Banerjee, Chris Fox, Rowan Harwood, Gill Livingston, Esme Moniz-Cook, Gregor Russell, Alan Thomas, Philip Wilkinson, Nick Freemantle, Rachael Maree Hunter
Publikováno v:
BJPsych Open, Vol 10 (2024)
Background Depression is common in people with dementia, and negatively affects quality of life. Aims This paper aims to evaluate the cost-effectiveness of an intervention for depression in mild and moderate dementia caused by Alzheimer's disease ov
Externí odkaz:
https://doaj.org/article/92772c9bcd8d4727a2f116462990d649
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Through predictive simulations, multibody models can aid the treatment of spinal pathologies by identifying optimal surgical procedures. Critical to achieving accurate predictions is the definition of the intervertebral joint. The joint pose is often
Externí odkaz:
https://doaj.org/article/ca269f79802b469a8c70f3cfdbc14c85
Autor:
Ana Belén Iglesias-Romero, Terersa Soto, Ignacio Flor-Parra, Silvia Salas-Pino, Gabriel Ruiz-Romero, Kathleen L. Gould, José Cansado, Rafael R. Daga
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into multiple adaptive responses. These responses involve transcriptional rewiring and the regulati
Externí odkaz:
https://doaj.org/article/be36313b2d3549719a218fbca1f39f4f
Autor:
Abigail M. Brown, Lindsay C. Meyers, Janani Varadarajan, Nicholas J. Ward, Jean‐Philippe Cartailler, Roger G. Chalkley, Kathleen L. Gould, Kimberly A. Petrie
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 11, Pp 427-452 (2023)
Abstract Biomedical sciences PhDs pursue a wide range of careers inside and outside academia. However, there is little data regarding how career interests of PhD students relate to the decision to pursue postdoctoral training or to their eventual car
Externí odkaz:
https://doaj.org/article/1ab1d5ad896c46e69235d15188f24fd0
Autor:
Rebecca L. Gould, Charlotte Rawlinson, Ben Thompson, Kirsty Weeks, Rebecca Gossage-Worrall, Hannah Cantrill, Marc A. Serfaty, Christopher D. Graham, Lance M. McCracken, David White, Robert J. Howard, Matt Bursnall, Mike Bradburn, Ammar Al-Chalabi, Richard Orrell, Suresh K. Chhetri, Rupert Noad, Aleksandar Radunovic, Tim Williams, Carolyn A. Young, David Dick, Vanessa Lawrence, Laura H. Goldstein, Tracey Young, John Ealing, Hamish McLeod, Nicola Williams, Helen Weatherly, Richard Cave, Theresa Chiwera, Francesco Pagnini, Cindy Cooper, Pamela J. Shaw, Christopher J. McDermott, and the COMMEND Collaboration Group
Publikováno v:
Pilot and Feasibility Studies, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Background Motor neuron disease (MND) is a fatal, progressive neurodegenerative disease that causes progressive weakening and wasting of limb, bulbar, thoracic and abdominal muscles. Clear evidence-based guidance on how psychological distres
Externí odkaz:
https://doaj.org/article/1f16105dce8c44dfaed6f28d5a4b1ea8
Autor:
Samuele L. Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction: Musculoskeletal multibody models of the spine can be used to investigate the biomechanical behaviour of the spine. In this context, a correct characterisation of the passive mechanical properties of the intervertebral joint is crucial.
Externí odkaz:
https://doaj.org/article/aed210ee35c7406da1e972a1818171f8
Autor:
Nathaniel L. Gould, Gila R. Scherer, Silvia Carvalho, Khriesto Shurrush, Haneen Kayyal, Efrat Edry, Alina Elkobi, Orit David, Maria Foqara, Darshit Thakar, Tommaso Pavesi, Vijendra Sharma, Matthew Walker, Matthew Maitland, Orly Dym, Shira Albeck, Yoav Peleg, Nicolas Germain, Ilana Babaev, Haleli Sharir, Maya Lalzar, Boris Shklyar, Neta Hazut, Mohammad Khamaisy, Maxime Lévesque, Gilles Lajoie, Massimo Avoli, Gabriel Amitai, Bruce Lefker, Chakrapani Subramanyam, Brian Shilton, Haim Barr, Kobi Rosenblum
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer’s disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the brain, i
Externí odkaz:
https://doaj.org/article/ac5cf5dd51f14d3ba8d30c4735cde0de
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010987 (2023)
Coupling cell wall expansion with cell growth is a universal challenge faced by walled organisms. Mutations in Schizosaccharomyces pombe css1, which encodes a PM inositol phosphosphingolipid phospholipase C, prevent cell wall expansion but not synthe
Externí odkaz:
https://doaj.org/article/7e1fb22ce6324b87ab7b109937d4355e
Autor:
Rebecca L. Gould, Benjamin J. Thompson, Charlotte Rawlinson, Pavithra Kumar, David White, Marc A. Serfaty, Christopher D. Graham, Lance M. McCracken, Matt Bursnall, Mike Bradburn, Tracey Young, Robert J. Howard, Ammar Al-Chalabi, Laura H. Goldstein, Vanessa Lawrence, Cindy Cooper, Pamela J. Shaw, Christopher J. McDermott
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Motor neuron disease (MND) is a rapidly progressive, fatal neurodegenerative disease that predominantly affects motor neurons from the motor cortex to the spinal cord and causes progressive wasting and weakening of bulbar, limb, a
Externí odkaz:
https://doaj.org/article/f13abace9f2343e7b3e06a0f72dff1ed