Zobrazeno 1 - 10
of 317
pro vyhledávání: '"A. L. Dill"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Genome assembly approaches are limited by factors including cost, power and incomplete resolution. Here, the authors present Aquila, a method that uses a reference sequence and linked read data to generate high quality diploid genome assemblies from
Externí odkaz:
https://doaj.org/article/510921fb5e644af2b377aa9970ed505a
Publikováno v:
Electronic Proceedings in Theoretical Computer Science, Vol 257, Iss Proc. FVAV 2017, Pp 19-26 (2017)
Autonomous vehicles are highly complex systems, required to function reliably in a wide variety of situations. Manually crafting software controllers for these vehicles is difficult, but there has been some success in using deep neural networks gener
Externí odkaz:
https://doaj.org/article/a514f56939b549819950c8f58fa3d54d
Autor:
Subarna Sinha, Daniel Thomas, Steven Chan, Yang Gao, Diede Brunen, Damoun Torabi, Andreas Reinisch, David Hernandez, Andy Chan, Erinn B. Rankin, Rene Bernards, Ravindra Majeti, David L. Dill
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
There are no robust methods for systematically identifying mutation-specific synthetic lethal (SL) partners in cancer. Here, the authors develop a computational algorithm that uses pan-cancer data to detect mutation-andcancer-specific SL partners and
Externí odkaz:
https://doaj.org/article/e49e620b8adf451f9e5a7aa02173d0b8
Autor:
Nathalie Y.R. Agar, R. Graham Cooks, Sandro Santagata, Keith L. Ligon, Alexandra J. Golby, Allison L. Dill, Isaiah Norton, Livia S. Eberlin
PDf file - 728K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5bfd5085733678eaf032ec4101c1c4
https://doi.org/10.1158/0008-5472.22395102
https://doi.org/10.1158/0008-5472.22395102
Publikováno v:
Formal Methods in System Design. 60:87-116
Deep neural networks have emerged as a widely used and effective means for tackling complex, real-world problems. However, a major obstacle in applying them to safety-critical systems is the great difficulty in providing formal guarantees about their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b78325d354e458e30ee4bf0be67870
https://doi.org/10.1007/s10703-021-00363-7
https://doi.org/10.1007/s10703-021-00363-7
Autor:
James D. Brooks, Rie von Eyben, Yang Li, Amato J. Giaccia, Anh N. Diep, Donna M. Peehl, James Broughton, Jose A. Seoane, Yiren Xiao, Jiangbin Ye, Erinn B. Rankin, Hongjuan Zhao, David L. Dill, Kaushik N. Thakkar, Subarna Sinha, Thomas J. Metzner, John T. Leppert, Christina Curtis
Publikováno v:
Proceedings of the National Academy of Sciences. 117:21441-21449
Loss of the von Hippel–Lindau (VHL) tumor suppressor is a hallmark feature of renal clear cell carcinoma. VHL inactivation results in the constitutive activation of the hypoxia-inducible factors (HIFs) HIF-1 and HIF-2 and their downstream targets,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1240e4286ca6c14c427e214d78cd014
https://doi.org/10.1073/pnas.2000516117
https://doi.org/10.1073/pnas.2000516117
Autor:
Cherokee S. Hoaglund Hyzer, Bruno Catacchio, Donnie Pulliam, Mingkun Fu, Chait Wannere, Yelizaveta Babayan, Allison L. Dill, Eric Adamec, Megan McMahon, Fenghe Qiu, Angela Coon, Robert Timpano, Lars Gruenig, Karina Szymulanska-Ramamurthy, Michael Lesslie, Brian P. Regler
Publikováno v:
Journal of Pharmaceutical Innovation. 16:566-574
Purpose Lean stability is a science- and risk-based initiative which utilizes the enhanced understanding of drug substance and drug product physical and chemical characteristics to (1) reduce and optimize the design of standard stability protocols; (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4437b626ad512d2419274099ad60dd05
https://doi.org/10.1007/s12247-020-09463-z
https://doi.org/10.1007/s12247-020-09463-z
Autor:
Tiffany L. Dill, Francisco J. Naya
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 5, Iss 3, p 37 (2018)
The imprinted Dlk1-Dio3 genomic region harbors a noncoding RNA cluster encoding over fifty microRNAs (miRNAs), three long noncoding RNAs (lncRNAs), and a small nucleolar RNA (snoRNA) gene array. These distinct noncoding RNAs (ncRNAs) are thought to a
Externí odkaz:
https://doaj.org/article/e3d4622ab7974c2e8ba721e0e61c458b
Autor:
Ming Zheng, Haili Zhang, David L Dill, J David Clark, Susan Tu, Arielle L Yablonovitch, Meng How Tan, Rui Zhang, Dan Rujescu, Manhong Wu, Lino Tessarollo, Wilfred Vieira, Michael M Gottesman, Suhua Deng, Livia S Eberlin, Richard N Zare, Jean-Martin Billard, Jean-Pierre Gillet, Jin Billy Li, Gary Peltz
Publikováno v:
PLoS Medicine, Vol 12, Iss 2, p e1001782 (2015)
We know very little about the genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, and this has limited our ability to optimally utilize existing drugs or to develop new drugs for CNS disorders. For exampl
Externí odkaz:
https://doaj.org/article/b2f23056989947ef8256583d59db6011
Autor:
Bo Zhou, Jared M Schrader, Virginia S Kalogeraki, Eduardo Abeliuk, Cong B Dinh, James Q Pham, Zhongying Z Cui, David L Dill, Harley H McAdams, Lucy Shapiro
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004831 (2015)
Each Caulobacter cell cycle involves differentiation and an asymmetric cell division driven by a cyclical regulatory circuit comprised of four transcription factors (TFs) and a DNA methyltransferase. Using a modified global 5' RACE protocol, we globa
Externí odkaz:
https://doaj.org/article/5d8969144c244a3fbe5a3b63edbe57a3