Výsledky vyhledávání - "A. L. Abrams"

Akademický článek

Respecting local knowledge keepers through cellphilms featuring local water bodies: towards decolonizing water management

Autor: S. Van Borek, A. L. Abrams

Publikováno v: Aqua, Vol 72, Iss 5, Pp 663-672 (2023)

This paper outlines arts-based methods aimed at exploring how storytelling with local knowledge keepers (KKs) through cellphilms featuring local waterways might contribute to decolonizing water management by uncovering different values of and relatio

Externí odkaz: https://doaj.org/article/2af7ff9e3e7640a2a066b1d836fa9b55

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Akademický článek

Managing stormwater in South African neighbourhoods: When engineers and scientists need social science skills to get their jobs done

Autor: C. T. Tanyanyiwa, A. L. Abrams, K. Carden, N. P. Armitage, R. Schneuwly, P. Mguni, L. Byskov Herslund, J. Mclachlan

Publikováno v: Aqua, Vol 72, Iss 4, Pp 456-464 (2023)

Stormwater harvesting via managed aquifer recharge in retrofitted infrastructure has been posited as a method for resource augmentation in Cape Town. However, the existing guidelines on stormwater retrofits are technically inclined, occidental, and g

Externí odkaz: https://doaj.org/article/3a867862c8ea4e22883a266908962edd

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Akademický článek

Echocardiographic and electrocardiographic findings in Irish Wolfhounds eating high‐pulse or low‐pulse diets

Autor: Lily M. Coppinger, Lisa M. Freeman, William D. Tyrrell Jr, Steven L. Rosenthal, Mariellen E. Dentino, Frances L. Abrams, John E. Rush

Publikováno v: Journal of Veterinary Internal Medicine, Vol 38, Iss 3, Pp 1300-1304 (2024)

Abstract Background Apparently healthy dogs of various breeds eating nontraditional, high‐pulse diets can have larger left ventricular diameter, lower systolic function, and more ventricular premature complexes (VPCs) compared with dogs eating trad

Externí odkaz: https://doaj.org/article/c733492b69924c02a9e210cd0b0fdad8

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Akademický článek

APR-246—The Mutant TP53 Reactivator—Increases the Effectiveness of Berberine and Modified Berberines to Inhibit the Proliferation of Pancreatic Cancer Cells

Autor: James Andrew McCubrey, Stephen L. Abrams, Linda S. Steelman, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Paolo Lombardi, Agnieszka Gizak, Przemysław Duda

Publikováno v: Biomolecules, Vol 12, Iss 2, p 276 (2022)

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. In ~75% of PDAC, the tumor suppressor TP53 gene is mutated. Novel approaches to treat cancer involve compounds called mutant TP53 reactivators. They interact with m

Externí odkaz: https://doaj.org/article/aac6b390233f4ba7924495fb91e906e6

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Akademický článek

Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53

Autor: Stephen L. Abrams, Przemysław Duda, Shaw M. Akula, Linda S. Steelman, Matilde L. Follo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Giuseppe Montalto, Maria Rita Emma, Melchiorre Cervello, Dariusz Rakus, Agnieszka Gizak, James A. McCubrey

Publikováno v: Cells, Vol 11, Iss 5, p 794 (2022)

The TP53 tumor suppressor is mutated in ~75% of pancreatic cancers. The mutant TP53 protein in pancreatic ductal adenocarcinomas (PDAC) promotes tumor growth and metastasis. Attempts have been made to develop molecules that restore at least some of t

Externí odkaz: https://doaj.org/article/b88503daf256434e9d204e634e50ec26

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Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties

Autor: James A. McCubrey, Akshaya K. Meher, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Michelle M. LaHair, Richard A. Franklin, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Fulvio Barbaro, Przemysław Duda, Agnieszka Gizak

Publikováno v: Aging. 14:3365-3386

TP53 is a master regulator of many signaling and apoptotic pathways involved in: aging, cell cycle progression, gene regulation, growth, apoptosis, cellular senescence, DNA repair, drug resistance, malignant transformation, metastasis, and metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edd25c24fbd50ad712ed6ca3b0705ab
https://doi.org/10.18632/aging.204038

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Akademický článek

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

Autor: Przemysław Duda, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Saverio Candido, Massimo Libra, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, James A. McCubrey

Publikováno v: Cells, Vol 9, Iss 5, p 1110 (2020)

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although GSK-3 originally was identified to have functions in regulation of glycogen synthase, it was subsequently determined to have roles in multiple normal biochemical

Externí odkaz: https://doaj.org/article/4013e82b8ba443de968a8ae058a04c3d

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