Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume

Autor: M. Desai, A. Kundu, M. Hageman, H. Lou, D. Boisvert

Publikováno v: mAbs, Vol 15, Iss 1 (2023)

ABSTRACTBiologic drugs are used to treat a variety of cancers and chronic diseases. While most of these treatments are administered intravenously by trained healthcare professionals, a noticeable trend has emerged favoring subcutaneous (SC) administr

Externí odkaz: https://doaj.org/article/0270db5f955147f4b112cea346da962a

Assessing the Performance of the DINOv2 Self-supervised Learning Vision Transformer Model for the Segmentation of the Left Atrium from MRI Images

Autor: Kundu, Bipasha, Khanal, Bidur, Simon, Richard, Linte, Cristian A.

Accurate left atrium (LA) segmentation from pre-operative scans is crucial for diagnosing atrial fibrillation, treatment planning, and supporting surgical interventions. While deep learning models are key in medical image segmentation, they often req

Externí odkaz: http://arxiv.org/abs/2411.09598

A System Level Performance Evaluation for Superconducting Digital Systems

Autor: Kundu, Joyjit, Bhattacharjee, Debjyoti, Josephsen, Nathan, Pokhrel, Ankit, De Silva, Udara, Guo, Wenzhe, Van Winckel, Steven, Brebels, Steven, Perumkunnil, Manu, Herr, Quentin, Herr, Anna

Publikováno v: DATE 2025

Superconducting Digital (SCD) technology offers significant potential for enhancing the performance of next generation large scale compute workloads. By leveraging advanced lithography and a 300 mm platform, SCD devices can reduce energy consumption

Externí odkaz: http://arxiv.org/abs/2411.08645

Elliptic curves of conductor $2^m p$, quadratic twists, and Watkins's conjecture

Autor: Hatley, Jeffrey, Kundu, Debanjana

Let $\mathsf{E}/\mathbb{Q}$ be an elliptic curve. By the modularity theorem, it admits a surjection from a modular curve $X_0(N) \to \mathsf{E}$, and the minimal degree among such maps is called the modular degree of $\mathsf{E}$. By the Mordell--Wei

Externí odkaz: http://arxiv.org/abs/2411.08321

High-Statistics Measurement of the Cosmic-Ray Electron Spectrum with H.E.S.S

Autor: Aharonian, F., Benkhali, F. Ait, Aschersleben, J., Ashkar, H., Backes, M., Martins, V. Barbosa, Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Borowska, J., Bouyahiaoui, M., Brose, R., Brown, A., Brun, F., Bruno, B., Bulik, T., Burger-Scheidlin, C., Bylund, T., Casanova, S., Celic, J., Cerruti, M., Chand, T., Chandra, S., Chen, A., Chibueze, J., Chibueze, O., Collins, T., Cotter, G., Mbarubucyeye, J. Damascene, Devin, J., Djuvsland, J., Dmytriiev, A., Egberts, K., Einecke, S., Ernenwein, J. -P., Fegan, S., Feijen, K., Fontaine, G., Funk, S., Gabici, S., Gallant, Y. A., Glicenstein, J. F., Glombitza, J., Grolleron, G., Heß, B., Hofmann, W., Holch, T. L., Holler, M., Horns, D., Huang, Zhiqiu, Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzynski, K., Kerszberg, D., Khatoon, R., Khelifi, B., Kluzniak, W., Komin, Nu., Kosack, K., Kostunin, D., Kundu, A., Lang, R. G., Stum, S. Le, Leitl, F., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Leuschner, F., Luashvili, A., Mackey, J., Malyshev, D., Marandon, V., Marinos, P., Marti-Devesa, G., Marx, R., Meyer, M., Mitchell, A., Moderski, R., Moghadam, M. O., Mohrmann, L., Montanari, A., Moulin, E., de Naurois, M., Niemiec, J., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, D., Pensec, U., Peron, G., Pühlhofer, G., Punch, M., Quirrenbach, A., Ravikularaman, S., Regeard, M., Reimer, A., Reimer, O., Reis, I., Ren, H., Reville, B., Rieger, F., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Salzmann, H., Santangelo, A., Sasaki, M., Schäfer, J., Schüssler, F., Schutte, H. M., Shapopi, J. N. S., Sharma, A., Sol, H., Spencer, S., Stawarz, L., Steinmassl, S., Steppa, C., Suzuki, H., Takahashi, T., Tanaka, T., Taylor, A. M., Terrier, R., Tsirou, M., van Eldik, C., Vecchi, M., Venter, C., Vink, J., Wach, T., Wagner, S. J., Wierzcholska, A., Zacharias, M., Zdziarski, A. A., Zech, A., Zywucka, N.

Owing to their rapid cooling rate and hence loss-limited propagation distance, cosmic-ray electrons and positrons (CRe) at very high energies probe local cosmic-ray accelerators and provide constraints on exotic production mechanisms such as annihila

Externí odkaz: http://arxiv.org/abs/2411.08189