Genomic and Functional Overlap between Somatic and Germline Chromosomal Rearrangements

Autor: Sebastiaan van Heesch, Marieke Simonis, Markus J. van Roosmalen, Vamsee Pillalamarri, Harrison Brand, Ewart W. Kuijk, Kim L. de Luca, Nico Lansu, A. Koen Braat, Androniki Menelaou, Wensi Hao, Jeroen Korving, Simone Snijder, Lars T. van der Veken, Ron Hochstenbach, Alida C. Knegt, Karen Duran, Ivo Renkens, Najla Alekozai, Myrthe Jager, Sarah Vergult, Björn Menten, Ewart de Bruijn, Sander Boymans, Elly Ippel, Ellen van Binsbergen, Michael E. Talkowski, Klaske Lichtenbelt, Edwin Cuppen, Wigard P. Kloosterman

Publikováno v: Cell Reports, Vol 9, Iss 6, Pp 2001-2010 (2014)

Genomic rearrangements are a common cause of human congenital abnormalities. However, their origin and consequences are poorly understood. We performed molecular analysis of two patients with congenital disease who carried de novo genomic rearrangeme

Externí odkaz: https://doaj.org/article/3fde279ae3264a15b1b84b25ba00f8e2

Loss of PRDM11 promotes MYC-driven lymphomagenesis

Autor: Carsten Friis, Kirsten Grønbæk, Linda Jacobsen, Christophe Côme, Klaus T. Jensen, Louise Rosgaard, Anders H. Lund, Cathrine K. Fog, Alison Louw, Fazila Asmar, Arie Koen Braat, Jens Vilstrup Johansen, Maarten van Lohuizen, Kristian Anthonsen, Elisabeth Ralfkiaer, Nina Friesgaard Øbro, Hanne Vibeke Marquart, Tony Bou Kheir

Publikováno v: Blood. 125:1272-1281

The PR-domain (PRDM) family of genes encodes transcriptional regulators, several of which are deregulated in cancer. By using a functional screening approach, we sought to identify novel tumor suppressors among the PRDMs. Here we demonstrate oncogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814892d084c3043b1616e6de49dfe3ea
https://doi.org/10.1182/blood-2014-03-560805

A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation

Autor: Lukas A. Huber, Ad J. M. Gillis, Marleen Blom, Hans Stoop, A. Koen Braat, Joseph H.A. Vissers, Marko Potman, Wouter Nijkamp, E. Verhoeven, Maarten van Lohuizen, Roderick L. Beijersbergen, Nicole Taub, Bart A. Westerman, Leendert H. J. Looijenga, Arno Velds

Publikováno v: Journal of experimental medicine, 208(13), 2675-2689. Rockefeller University Press
The Journal of Experimental Medicine
Journal of Experimental Medicine, 208(13), 2675-2689. Rockefeller University Press
Westerman, B A, Braat, A K, Taub, N, Potman, M, Vissers, J H A, Blom, M, Verhoeven, E, Stoop, H, Gillis, A, Velds, A, Nijkamp, W, Beijersbergen, R, Huber, L A, Looijenga, L H J & van Lohuizen, M 2011, ' A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation ', Journal of Experimental Medicine, vol. 208, no. 13, pp. 2675-2689 . https://doi.org/10.1084/jem.20102037

Knockdown of the scaffolding protein Mek binding protein 1 (Mp1) in mouse embryonic stem cells suppresses differentiation but not proliferation, and more invasive human germ cell tumors express lower amounts of Mp1.
Despite intense investigation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22aa384157972ff0f382ecc57131e12
https://doi.org/10.1084/jem.20102037

Characterization of zebrafish primordial germ cells: Morphology and early distribution ofvasa RNA

Autor: Sandra van de Water, Henk J.Th. Goos, Thijs Zandbergen, Danica Zivkovic, Arie Koen Braat

Publikováno v: Developmental Dynamics. 216:153-167

Research into germ line development is of conceptual and biotechnologic importance. In this study, we used morphology at the level of light and electron microscope to characterize the primordial germ cells (PGCs) of the zebrafish throughout embryonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b6980a62ad8e5c0053b4ade1b393b1d
https://doi.org/10.1002/(sici)1097-0177(199910)216:2<153::aid-dvdy6>3.0.co

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy

Autor: Boudewijn M.T. Burgering, Cornelieke Pals, Frank C. P. Holstege, Ruben van Boxtel, Sebastian Zellmer, Mario Mauthe, Rolf Gebhardt, Tassula Proikas-Cezanne, Marrit Putker, Marian J. A. Groot Koerkamp, Stephin J. Vervoort, Liesbeth P. Verhagen, Kristan E. van der Vos, Paul J. Coffer, Iris J. van Zutphen, Tobias B. Dansen, A. Koen Braat, Pernilla Eliasson

Publikováno v: Nature Cell Biology, 14(8), 829-837. Nature Publishing Group

The PI(3)K-PKB-FOXO signalling network provides a major intracellular hub for the regulation of cell proliferation, survival and stress resistance. Here we report an unexpected role for FOXO transcription factors in regulating autophagy by modulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193047a8ba5a6d1f380b3153a2fbb7fa
https://research.rug.nl/en/publications/74b026e3-fce9-4fcf-95a6-12e75cb339e3