Zobrazeno 1 - 10
of 1 575
pro vyhledávání: '"A. Kipar"'
Autor:
Cordelia Dunai, Claire Hetherington, Sarah A. Boardman, Jordan J. Clark, Parul Sharma, Krishanthi Subramaniam, Kukatharmini Tharmaratnam, Edward J. Needham, Robyn Williams, Yun Huang, Greta K. Wood, Ceryce Collie, Andrew Fower, Hannah Fox, Mark A. Ellul, Marie Held, Franklyn N. Egbe, Michael Griffiths, Tom Solomon, Gerome Breen, Anja Kipar, Jonathan Cavanagh, Sarosh R. Irani, Angela Vincent, James P. Stewart, Leonie S. Taams, David K. Menon, Benedict D. Michael
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected in the brain parenchyma. To model this situation, we developed a novel low-inoculum K18-hACE2 mo
Externí odkaz:
https://doaj.org/article/b407a024b99e4716aa954f209f08e65d
Autor:
Irma Telarovic, Carmen S. M. Yong, Lisa Kurz, Irene Vetrugno, Sabrina Reichl, Alba Sanchez Fernandez, Hung-Wei Cheng, Rona Winkler, Matthias Guckenberger, Anja Kipar, Burkhard Ludewig, Martin Pruschy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Cancer resistance to immune checkpoint inhibitors motivated investigations into leveraging the immunostimulatory properties of radiotherapy to overcome immune evasion and to improve treatment response. However, clinical benefits of radiother
Externí odkaz:
https://doaj.org/article/5e4fb3861c2944398416dd9f676c87db
Autor:
E.M. Spencer, K.E. Chandler, K. Haddley, M.R. Howard, D. Hughes, N.D. Belyaev, J.M. Coulson, J.P. Stewart, N.J. Buckley, A. Kipar, M.C. Walker, J.P. Quinn
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 1, Pp 41-52 (2006)
Repressor element-1 silencing transcription factor (REST) is a candidate modulator of gene expression during status epilepticus in the rodent. In such models, full-length REST and the truncated REST4 variant are induced and can potentially direct dif
Externí odkaz:
https://doaj.org/article/491e5c421fd942f6ae950887f8cea208
Autor:
Luz E Cabrera, Suvi T Jokiranta, Sanna Mäki, Simo Miettinen, Ravi Kant, Lauri Kareinen, Tarja Sironen, Jukka-Pekka Pietilä, Anu Kantele, Eliisa Kekäläinen, Hanna Lindgren, Pirkko Mattila, Anja Kipar, Olli Vapalahti, Tomas Strandin
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012368 (2024)
The severity of COVID-19 is linked to excessive inflammation. Neutrophils represent a critical arm of the innate immune response and are major mediators of inflammation, but their role in COVID-19 pathophysiology remains poorly understood. We conduct
Externí odkaz:
https://doaj.org/article/d08c9a0c6bf14abc8cfd31ca9ef6a0ed
Autor:
Lee Tatham, Anja Kipar, Jo Sharp, Edyta Kijak, Joanne Herriott, Megan Neary, Helen Box, Eduardo Gallardo Toledo, Anthony Valentijn, Helen Cox, Henry Pertinez, Paul Curley, Usman Arshad, Rajith Kumar Reddy Rajoli, Steve Rannard, James P. Stewart, Andrew Owen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT With some exceptions, global policymakers have recommended against the use of existing monoclonal antibodies in COVID-19 due to loss of neutralization of newer variants. The purpose of this study was to investigate the impact of Ronapreve on
Externí odkaz:
https://doaj.org/article/f7da676fb57b4ce9b203c40c216624a1
Publikováno v:
Viruses, Vol 16, Iss 11, p 1730 (2024)
Bovine gammaherpesvirus 6 (BoHV-6) is endemic in cattle in Europe, with a high prevalence. There is evidence that the virus is a commensal and not associated with disease processes. For other gammaherpesviruses, it is known that they have a rather sp
Externí odkaz:
https://doaj.org/article/fdfd423edf824d4d9c670bf6aae256cf
Autor:
Katy Cornish, Jiandong Huo, Luke Jones, Parul Sharma, Joseph W. Thrush, Sahar Abdelkarim, Anja Kipar, Siva Ramadurai, Miriam Weckener, Halina Mikolajek, Sai Liu, Imogen Buckle, Eleanor Bentley, Adam Kirby, Ximeng Han, Stephen M. Laidlaw, Michelle Hill, Lauren Eyssen, Chelsea Norman, Audrey Le Bas, John Clarke, William James, James P. Stewart, Miles Carroll, James H. Naismith, Raymond J. Owens
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
The Omicron strains of SARS-CoV-2 pose a significant challenge to the development of effective antibody-based treatments as immune evasion has compromised most available immune therapeutics. Therefore, in the ‘arms race’ with the virus, there is
Externí odkaz:
https://doaj.org/article/724360808c1547398a8abe34b3a38c53
Autor:
Liina Hannula, Suvi Kuivanen, Jonathan Lasham, Ravi Kant, Lauri Kareinen, Mariia Bogacheva, Tomas Strandin, Tarja Sironen, Jussi Hepojoki, Vivek Sharma, Petri Saviranta, Anja Kipar, Olli Vapalahti, Juha T. Huiskonen, Ilona Rissanen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTIn response to the ongoing COVID-19 pandemic, the quest for coronavirus inhibitors has inspired research on a variety of small proteins beyond conventional antibodies, including robust single-domain antibody fragments, i.e., “nanobodies.”
Externí odkaz:
https://doaj.org/article/cecbf8f257de4f2482e0413c26276bab
Autor:
Juliette Kuhn, Iris Marti, Marie-Pierre Ryser-Degiorgis, Kerstin Wernike, Sarah Jones, Grace Tyson, Gary Delalay, Patrick Scherrer, Stéphanie Borel, Margaret J. Hosie, Anja Kipar, Evelyn Kuhlmeier, Tatjana Chan, Regina Hofmann-Lehmann, Marina L. Meli
Publikováno v:
Viruses, Vol 16, Iss 9, p 1407 (2024)
Amid the SARS-CoV-2 pandemic, concerns surfaced regarding the spread of the virus to wildlife. Switzerland lacked data concerning the exposure of free-ranging animals to SARS-CoV-2 during this period. This study aimed to investigate the potential exp
Externí odkaz:
https://doaj.org/article/95be399f8d14499a932bd6c969420796
Autor:
Zhuang, Xiaodong, Gallo, Giulia, Sharma, Parul, Ha, Jiyeon, Magri, Andrea, Borrmann, Helene, Harris, James M., Tsukuda, Senko, Bentley, Eleanor, Kirby, Adam, de Neck, Simon, Yang, Hongbing, Balfe, Peter, Wing, Peter A.C., Matthews, David, Harris, Adrian L., Kipar, Anja, Stewart, James P., Bailey, Dalan, McKeating, Jane A.
Publikováno v:
In iScience 19 January 2024 27(1)