Zobrazeno 1 - 10
of 1 740
pro vyhledávání: '"A. Kerksiek"'
Autor:
Spinedi, Matteo, Clark, Christopher, Zullo, Leonardo, Kerksiek, Anja, Pistis, Giorgio, Castelao, Enrique, von Gunten, Armin, Preisig, Martin, Lütjohann, Dieter, Popp, Julius
Publikováno v:
In iScience 16 February 2024 27(2)
Autor:
Matteo Spinedi, Christopher Clark, Leonardo Zullo, Anja Kerksiek, Giorgio Pistis, Enrique Castelao, Armin von Gunten, Martin Preisig, Dieter Lütjohann, Julius Popp
Publikováno v:
iScience, Vol 27, Iss 2, Pp 109013- (2024)
Summary: Neurodegenerative, vascular, and dementia diseases are linked to dysregulations in cholesterol metabolism. Dietary plant sterols, or phytosterols, may interfere to neurodegeneration and cognitive decline, and have cholesterol-lowering, anti-
Externí odkaz:
https://doaj.org/article/679ba0983d91415e9526cf37ffdc8e96
Autor:
Kiss, Robert S., Chicoine, Jarred, Khalil, Youssef, Sladek, Robert, Chen, He, Pisaturo, Alessandro, Martin, Cyril, Dale, Jessica D., Brudenell, Tegan A., Kamath, Archith, Kyei-Boahen, Jeffrey, Hafiane, Anouar, Daliah, Girija, Alecki, Célia, Hopes, Tayah S., Heier, Martin, Aligianis, Irene A., Lebrun, Jean-Jacques, Aspden, Julie, Paci, Emanuele, Kerksiek, Anja, Lütjohann, Dieter, Clayton, Peter, Wills, Jimi C., von Kriegsheim, Alex, Nilsson, Tommy, Sheridan, Eamonn, Handley, Mark T.
Publikováno v:
In Journal of Biological Chemistry November 2023 299(11)
Autor:
Marietta Fabiano, Naoto Oikawa, Anja Kerksiek, Jun-ichi Furukawa, Hirokazu Yagi, Koichi Kato, Ulrich Schweizer, Wim Annaert, Jongkyun Kang, Jie Shen, Dieter Lütjohann, Jochen Walter
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5417 (2024)
Presenilin proteins (PS1 and PS2) represent the catalytic subunit of γ-secretase and play a critical role in the generation of the amyloid β (Aβ) peptide and the pathogenesis of Alzheimer disease (AD). However, PS proteins also exert multiple func
Externí odkaz:
https://doaj.org/article/af385f8c8b2f4b14a98185444d0c55c1
Autor:
Clark, Christopher, Gholam, Mehdi, Zullo, Leonardo, Kerksiek, Anja, Castelao, Enrique, von Gunten, Armin, Preisig, Martin, Lütjohann, Dieter, Popp, Julius
Publikováno v:
In iScience 16 June 2023 26(6)
Autor:
Christopher Clark, Mehdi Gholam, Leonardo Zullo, Anja Kerksiek, Enrique Castelao, Armin von Gunten, Martin Preisig, Dieter Lütjohann, Julius Popp
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106740- (2023)
Summary: Dysregulations in cholesterol metabolism are associated with neurodegenerative and vascular pathologies, and dementia. Diet-derived plant sterols (phytosterols) have cholesterol-lowering, anti-inflammatory, and antioxidant properties and may
Externí odkaz:
https://doaj.org/article/0af2c3be12fb4d51ace2f4d09437cedc
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Autor:
Mustafa Yalcinkaya, Anja Kerksiek, Katrin Gebert, Wijtske Annema, Rahel Sibler, Silvija Radosavljevic, Dieter Lütjohann, Lucia Rohrer, Arnold von Eckardstein
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 4, Pp 492-504 (2020)
Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well a
Externí odkaz:
https://doaj.org/article/5d1ba45ad54d475ca39156b754feed59
Autor:
Fuhrmann, Arne, Weingärtner, Oliver, Meyer, Sven, Cremers, Bodo, Seiler-Mußler, Sarah, Schött, Hans-F., Kerksiek, Anja, Friedrichs, Silvia, Ulbricht, Ursula, Zawada, Adam M., Laufs, Ulrich, Scheller, Bruno, Fliser, Danilo, Schulze, Paul Christian, Böhm, Michael, Heine, Gunnar H., Lütjohann, Dieter
Publikováno v:
In Atherosclerosis December 2018 279:17-22
Autor:
Júlia Canet-Pons, Nesli-Ece Sen, Aleksandar Arsović, Luis-Enrique Almaguer-Mederos, Melanie V. Halbach, Jana Key, Claudia Döring, Anja Kerksiek, Gina Picchiarelli, Raphaelle Cassel, Frédérique René, Stéphane Dieterlé, Nina V. Fuchs, Renate König, Luc Dupuis, Dieter Lütjohann, Suzana Gispert, Georg Auburger
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105289- (2021)
Large polyglutamine expansions in Ataxin-2 (ATXN2) cause multi-system nervous atrophy in Spinocerebellar Ataxia type 2 (SCA2). Intermediate size expansions carry a risk for selective motor neuron degeneration, known as Amyotrophic Lateral Sclerosis (
Externí odkaz:
https://doaj.org/article/52a024677ac64e5d9a2e23fc61696b54