Zobrazeno 1 - 10
of 74
pro vyhledávání: '"A. K. Wege"'
Autor:
Daniela Schulz, Laura Feulner, Dominique Santos Rubenich, Sina Heimer, Sophia Rohrmüller, Yvonne Reinders, Marcelo Falchetti, Martin Wetzel, Elizandra Braganhol, Edroaldo Lummertz da Rocha, Nicole Schäfer, Sabine Stöckl, Gero Brockhoff, Anja K. Wege, Jürgen Fritsch, Fabian Pohl, Torsten E. Reichert, Tobias Ettl, Richard J. Bauer
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 431-452 (2024)
The programmed cell death 1 ligand 1 (PD‐L1)/programmed cell death protein 1 (PD‐1) axis is primarily associated with immunosuppression in cytotoxic T lymphocytes (CTLs). However, mounting evidence is supporting the thesis that PD‐L1 not only f
Externí odkaz:
https://doaj.org/article/19e719a9435c482aa6a7f4c3dac48db2
Autor:
Christina Bruss, Veruschka Albert, Stephan Seitz, Stephanie Blaimer, Kerstin Kellner, Fabian Pohl, Olaf Ortmann, Gero Brockhoff, Anja K. Wege
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Pre-operative radiation therapy is not currently integrated into the treatment protocols for breast cancer. However, transforming immunological “cold” breast cancers by neoadjuvant irradiation into their “hot” variants is supposed to elicit a
Externí odkaz:
https://doaj.org/article/a00b7cc954714b9ba261cd27888f6f00
Autor:
Lia Walcher, Nadja Hilger, Anja K. Wege, Franziska Lange, U. Sandy Tretbar, André‐René Blaudszun, Stephan Fricke
Publikováno v:
Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 363-370 (2020)
Abstract Introduction Models of mice carrying a human immune system, so‐called humanized mice, are used increasingly as preclinical models to bridge the gap between model organisms and human beings. Challenges of the humanized mouse model include f
Externí odkaz:
https://doaj.org/article/95318c3a61a54935998e827bbec93457
Autor:
Paloma Riquelme, Jan Haarer, Anja Kammler, Lisa Walter, Stefan Tomiuk, Norbert Ahrens, Anja K. Wege, Ivan Goecze, Daniel Zecher, Bernhard Banas, Rainer Spang, Fred Fändrich, Manfred B. Lutz, Birgit Sawitzki, Hans J. Schlitt, Jordi Ochando, Edward K. Geissler, James A. Hutchinson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs ma
Externí odkaz:
https://doaj.org/article/bde1072b3b4842efb0f1df25fc4a3f9e
Autor:
Fernanda Ramos-Gomes, Julia Bode, Alyona Sukhanova, Svetlana V. Bozrova, Mara Saccomano, Miso Mitkovski, Julia Eva Krueger, Anja K. Wege, Walter Stuehmer, Pavel S. Samokhvalov, Daniel Baty, Patrick Chames, Igor Nabiev, Frauke Alves
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Early detection of malignant tumours and, especially, micrometastases and disseminated tumour cells is still a challenge. In order to implement highly sensitive diagnostic tools we demonstrate the use of nanoprobes engineered from nanobodies
Externí odkaz:
https://doaj.org/article/31f241baea3d44148c2b495267e0f415
Publikováno v:
Molecular Therapy: Oncolytics, Vol 5, Iss C, Pp 41-61 (2017)
Oncolytic vaccinia virus (VACV) therapy is an alternative cancer treatment modality that mediates targeted tumor destruction through a tumor-selective replication and an induction of anti-tumor immunity. We developed a humanized tumor mouse model wit
Externí odkaz:
https://doaj.org/article/edcec4d93cc046278ffd6f5ee17b6bd9
Autor:
Holger Bronger, Gabriele Multhoff, Viktor Magdolen, Ute Reuning, Marion Kiechle, Julia Dorn, Manfred Schmitt, Jürgen Ruland, Wilko Weichert, Anja K. Wege, Aurelia Noske, Alexander Hapfelmeier, Stefan Stangl, Stefanie Seitz, Wolfgang Sievert, Jil Jelsma, Daniela Schilling, Nadine Heithorst, Christoph Stange, Sabine Kuhn, Tobias F. Dreyer
Patient characteristics of the whole breast cancer cohort used for CX3CL1 expression analysis (n=250)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294517599c0d0d4d5a2ae3dce6640ee5
https://doi.org/10.1158/2326-6066.22543890
https://doi.org/10.1158/2326-6066.22543890
Autor:
Holger Bronger, Gabriele Multhoff, Viktor Magdolen, Ute Reuning, Marion Kiechle, Julia Dorn, Manfred Schmitt, Jürgen Ruland, Wilko Weichert, Anja K. Wege, Aurelia Noske, Alexander Hapfelmeier, Stefan Stangl, Stefanie Seitz, Wolfgang Sievert, Jil Jelsma, Daniela Schilling, Nadine Heithorst, Christoph Stange, Sabine Kuhn, Tobias F. Dreyer
CX3CL1 mRNA expression is associated with improved recurrence-free, distant-metastasis free, and overall survival in human breast cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095d42e442b47dc9109ad0a4e9eb9db2
https://doi.org/10.1158/2326-6066.22543914.v1
https://doi.org/10.1158/2326-6066.22543914.v1
Autor:
Holger Bronger, Gabriele Multhoff, Viktor Magdolen, Ute Reuning, Marion Kiechle, Julia Dorn, Manfred Schmitt, Jürgen Ruland, Wilko Weichert, Anja K. Wege, Aurelia Noske, Alexander Hapfelmeier, Stefan Stangl, Stefanie Seitz, Wolfgang Sievert, Jil Jelsma, Daniela Schilling, Nadine Heithorst, Christoph Stange, Sabine Kuhn, Tobias F. Dreyer
A crucial mode of action of trastuzumab is the labeling of HER2-positive (HER2+) tumor cells for the eradication by natural killer (NK) cells, a process called antibody-dependent cellular cytotoxicity (ADCC). However, despite widespread HER2 expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7916972621b15ba7ad93f29035da6c
https://doi.org/10.1158/2326-6066.c.6550452.v1
https://doi.org/10.1158/2326-6066.c.6550452.v1
Autor:
Albrecht Schwab, Christin Emming, Zoltán Pethő, Rita Schröter, Anja K. Wege, Pavel I. Nedvetsky, Julia Harms, Justine Guske, Simona Mareike Lüttgenau, Ute Neugebauer, Michael P. Krahn, Katrin Weber, Olga Panichkina, Thomas Wagner, Florian Weber
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Molecular Cancer
Molecular Cancer
Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals1 is affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68251a2d6690ffa704c97e9b102cd182
https://doaj.org/article/2474a5be80114ad884671a3f42dd5a01
https://doaj.org/article/2474a5be80114ad884671a3f42dd5a01