Zobrazeno 1 - 10
of 60
pro vyhledávání: '"A. K. Shchyolkina"'
Autor:
Galina V. Chashchina, Anna K. Shchyolkina, Simon V. Kolosov, Artemy D. Beniaminov, Dmitry N. Kaluzhny
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Evolutionary conservation or over-representation of the potential G-quadruplex sequences (PQS) in genomes are usually considered as a sign of the functional relevance of these sequences. However, uneven base distribution (GC-content) along the genome
Externí odkaz:
https://doaj.org/article/c9a55947a72a4e18a0162010d411281a
Autor:
Artemy D Beniaminov, Lyubov G Dezhenkova, Olga K Mamaeva, Anna K Shchyolkina, Anna N Tevyashova, Dmitry N Kaluzhny, Alexander A Shtil
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191923 (2018)
The current model of binding of the antitumor antibiotic olivomycin A (1) to GC-rich DNA regions presumes that coordination of the magnesium divalent cation with drug dimers is necessary for binding of 1 into the minor groove of the DNA duplex. Previ
Externí odkaz:
https://doaj.org/article/de18a24dbaca4e2fbd897f7073dd323c
Autor:
A. D. Beniaminov, Simon V Kolosov, Dmitry N. Kaluzhny, Galina V Chashchina, Anna K. Shchyolkina
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Frontiers in Microbiology
Frontiers in Microbiology
Evolutionary conservation or over-representation of the potential G-quadruplex sequences (PQS) in genomes are usually considered as a sign of the functional relevance of these sequences. However, uneven base distribution (GC-content) along the genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ee06a295e7bbd0c938ee706a5a4035
https://www.frontiersin.org/articles/10.3389/fmicb.2021.647851/full
https://www.frontiersin.org/articles/10.3389/fmicb.2021.647851/full
Publikováno v:
Biochimie. 191
Major advances have been made recently in the application of the highly selective G4 DNA ligand pyridostatin (PDS) for targeting and visualization of this noncanonical DNA structure in eukaryotic genomes. However, the interaction of PDS with the G4 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b9ca36af652dd4847b29e8aff0a759
https://pubmed.ncbi.nlm.nih.gov/34418485
https://pubmed.ncbi.nlm.nih.gov/34418485
Autor:
Dmitry N. Kaluzhny, Anna K. Shchyolkina, Nikolay S. Ilyinsky, Olga F. Borisova, Alexander A. Shtil
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
The indolocarbazole derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione (AIC) has demonstrated a high potency (at nanomolar to submicromolar concentrations) towards the NCI panel of human tumor cell lines and transplan
Externí odkaz:
https://doaj.org/article/af0e9d5f120c4a9bb51759db53fcab76
Autor:
Roman A. Novikov, Vladimir A. Mitkevich, Anna K. Shchyolkina, Igor P. Smirnov, O. K. Mamaeva, A. D. Beniaminov, M. A. Livshits, Dmitry N. Kaluzhny
Publikováno v:
Nucleic Acids Research
Structure-specific ligands are convenient tools for the recognition, targeting or probing of non-canonical DNA structures. Porphyrin derivatives exhibit a preference for interaction with G-quadruplex (G4) structures over canonical duplex DNA and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f44ebfa3b431c5fcf9254bc35095951
http://europepmc.org/articles/PMC5137456
http://europepmc.org/articles/PMC5137456
Autor:
M. A. Livshits, Galina V. Chashchina, Anna K. Shchyolkina, Dmitry N. Kaluzhny, Olga I. Kechko, O. K. Mamaeva, Vladimir A. Mitkevich, Anna N. Tevyashova, A. D. Beniaminov, Alexander A. Shtil
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5299, p 5299 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 15
International Journal of Molecular Sciences
Volume 21
Issue 15
Olivomycin A (OA) exerts its cytotoxic potency due to binding to the minor groove of the G/C-rich DNA and interfering with replication and transcription. Screening of the complete set of tetranucleotide G/C sites by electrophoretic mobility gel shift
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca139d2becc977c9512d81251a8dfd2
https://doi.org/10.3390/ijms21155299
https://doi.org/10.3390/ijms21155299
Autor:
Anna N. Tevyashova, Anna K. Shchyolkina, Alexander A. Shtil, A. D. Beniaminov, O. K. Mamaeva, Lyubov G. Dezhenkova, Dmitry N. Kaluzhny
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0191923 (2018)
PLoS ONE, Vol 13, Iss 2, p e0191923 (2018)
The current model of binding of the antitumor antibiotic olivomycin A (1) to GC-rich DNA regions presumes that coordination of the magnesium divalent cation with drug dimers is necessary for binding of 1 into the minor groove of the DNA duplex. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec17edd0502551c55f168b994cfca85b
http://europepmc.org/articles/PMC5805246
http://europepmc.org/articles/PMC5805246
Autor:
Dulat M. Azhibek, Andrey E. Shchekotikhin, Maria I. Zvereva, Nikolay S. Ilyinsky, Yuri N. Luzikov, Yuri B. Sinkevich, Jan Balzarini, Ekaterina S. Kolotova, Dmitry N. Kaluzhny, Alexander A. Shtil, Olga F. Borisova, Anna K. Shchyolkina, M. A. Livshits, O. K. Mamaeva, Lybov G. Dezhenkova, Vladimir A. Mitkevich
Publikováno v:
European Journal of Medicinal Chemistry. 85:605-614
Novel generations of antitumor anthraquinones are expected to be advantageous over the conventional chemotherapeutic agents. Previous structure–activity relationship studies demonstrated an importance of the positively charged side chains conjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b2e2af2ec77d88af87204cbc981260
https://doi.org/10.1016/j.ejmech.2014.08.030
https://doi.org/10.1016/j.ejmech.2014.08.030
Autor:
Valentina A. Ol'shevskaya, O. K. Mamaeva, Olga F. Borisova, Lyubov G. Dezhenkova, Alexander S. Semeikin, Dmitry N. Kaluzhny, Vladimir B. Tsvetkov, Anna K. Shchyolkina, Alexander A. Shtil, Oxana A. Kovaleva, Anton V. Makarenkov
Publikováno v:
European Biophysics Journal. 43:545-554
The porphyrin-based photosensitizers capable of binding to DNA are perspective drug candidates. Here we report the interactions with calf thymus DNA of 5,10,15,20-tetrakis(N-carboxymethyl-4-pyridinium)porphyrin (P1) and its derivatives containing Zn(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a312d6e163d5a357bcc2bf076064a6
https://doi.org/10.1007/s00249-014-0984-7
https://doi.org/10.1007/s00249-014-0984-7