Zobrazeno 1 - 10
of 991
pro vyhledávání: '"A. K. Rustgi"'
Autor:
Rafaela Muniz de Queiroz, Gizem Efe, Asja Guzman, Naoko Hashimoto, Yusuke Kawashima, Tomoaki Tanaka, Anil K. Rustgi, Carol Prives
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Although the E3 ligase Mdm2 and its homologue and binding partner MdmX are the major regulators of the p53 tumor suppressor protein, it is now evident that Mdm2 and MdmX have multiple functions that do not involve p53. As one example, it is
Externí odkaz:
https://doaj.org/article/6c7075f8b8934d2fa532d7c44cb97399
Autor:
Ankoor H. Patel, Gaurav N. Pathak, Alexander Chen, Patricia Greenberg, Natale Mazzaferro, Anish Patel, Naveen Mallangada, Carlos D. Minacapelli, Kaitlyn Catalano, Hansel Suthar, Vinod K. Rustgi
Publikováno v:
Annals of Hepatology, Vol 29, Iss 4, Pp 101510- (2024)
Introduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH) and, ultimately, cirrhosis. Clostridioides difficile is the most common nosocom
Externí odkaz:
https://doaj.org/article/c6826053a4214e9f97a2217185d5bd24
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 687-695 (2024)
Cancer-associated fibroblasts (CAFs), a heterogenous population, can promote cancer cell proliferation, migration, invasion, immunosuppression, and therapeutic resistance in solid tumors. These effects are mediated through secretion of cytokines and
Externí odkaz:
https://doaj.org/article/d688ca4b1e51409ca99effbc12d1f412
Autor:
Kyung-Pil Ko, Shengzhe Zhang, Yuanjian Huang, Bongjun Kim, Gengyi Zou, Sohee Jun, Jie Zhang, Yahui Zhao, Cecilia Martin, Karen J. Dunbar, Gizem Efe, Anil K. Rustgi, Hiroshi Nakagawa, Haiyang Zhang, Zhihua Liu, Jae-Il Park
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109795- (2024)
Summary: Despite the promising outcomes of immune checkpoint inhibitors (ICIs), resistance to ICI presents a new challenge. Therefore, selecting patients for specific ICI applications is crucial for maximizing therapeutic efficacy. Herein, we curated
Externí odkaz:
https://doaj.org/article/b0c57a6133c14aa2a1408bad70cd2bfc
Autor:
Sureshkumar Muthupalani, Damodaran Annamalai, Yan Feng, Suresh M. Ganesan, Zhongming Ge, Mark T. Whary, Hiroshi Nakagawa, Anil K. Rustgi, Timothy C. Wang, James G. Fox
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Chronic inflammation is integral to the development of esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), although the latter has not been associated with reflux esophagitis. The L2-IL-1β transgenic mice, express
Externí odkaz:
https://doaj.org/article/0af10e9a26bd4833b248f2606b9d7ca3
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 4, Pp 445- (2024)
Externí odkaz:
https://doaj.org/article/56b577b80a8242d3a0acf3e3add11f69
Autor:
Mohamed I Elsaid, John F P Bridges, Khalid Mumtaz, Na Li, Lindsay Sobotka, Vinod K Rustgi, Electra D Paskett
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299836 (2024)
Background & aimsPrevious studies have examined the effects of metabolic syndrome (MetS) rather than its severity on race and ethnic disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). We used the MetS severity score, a v
Externí odkaz:
https://doaj.org/article/38b7658323ba46738bcd0530f58c160d
Autor:
Yue Sandra Yin, Carlos D. Minacapelli, Veenat Parmar, Carolyn C. Catalano, Abhishek Bhurwal, Kapil Gupta, Vinod K. Rustgi, Martin J. Blaser
Publikováno v:
Molecular Biomedicine, Vol 3, Iss 1, Pp 1-14 (2022)
Abstract People with acute COVID-19 due to SARS-CoV-2 infection experience a range of symptoms, but major factors contributing to severe clinical outcomes remain to be understood. Emerging evidence suggests associations between the gut microbiome and
Externí odkaz:
https://doaj.org/article/567770594b9c46e4ab3cd9909a0f20c6
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer pro
Externí odkaz:
https://doaj.org/article/fecd2f81e26b43a3b3aad7932728969f
Autor:
Kensuke Sugiura, Yasunori Masuike, Kensuke Suzuki, Alice E. Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner, Anil K. Rustgi
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial
Externí odkaz:
https://doaj.org/article/4cc16e72c1d5417fbecfca91adb61af1