Spatial structure impacts adaptive therapy by shaping intra-tumoral competition

Autor: Maximilian A. R. Strobl, Jill Gallaher, Jeffrey West, Mark Robertson-Tessi, Philip K. Maini, Alexander R. A. Anderson

Publikováno v: Communications Medicine, Vol 2, Iss 1, Pp 1-18 (2022)

Strobl et al. develop an agent-based spatial model of drug resistance in tumour cells under adaptive therapy. Using this model, they investigate how the tumour’s spatial architecture impacts intratumoural competitive dynamics of drug-sensitive vs.

Externí odkaz: https://doaj.org/article/6398a24b99384ae086f2c9a62bb96631

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles

Autor: Andreas Walker, Tatjana Schwarz, Janine Brinkmann-Paulukat, Karin Wisskirchen, Christopher Menne, Elahe Salimi Alizei, Helenie Kefalakes, Martin Theissen, Daniel Hoffmann, Julian Schulze zur Wiesch, Mala K. Maini, Markus Cornberg, Anke RM Kraft, Verena Keitel, Hans H. Bock, Peter A. Horn, Robert Thimme, Heiner Wedemeyer, Falko M. Heinemann, Tom Luedde, Christoph Neumann-Haefelin, Ulrike Protzer, Jörg Timm

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Background and aimsThere is growing interest in T cell-based immune therapies for a functional cure of chronic HBV infection including check-point inhibition, T cell-targeted vaccines or TCR-grafted effector cells. All these approaches depend on reco

Externí odkaz: https://doaj.org/article/a835df343e524209b827b09b26d8af46

Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response

Autor: Ivan Doykov, Tomas Baldwin, Justyna Spiewak, Kimberly C. Gilmour, Joseph M. Gibbons, Corinna Pade, Catherine J. Reynolds, Áine McKnight, Mahdad Noursadeghi, Mala K. Maini, Charlotte Manisty, Thomas Treibel, Gabriella Captur, Marianna Fontana, Rosemary J. Boyton, Daniel M. Altmann, Tim Brooks, Amanda Semper, James C. Moon, Kevin Mills, Wendy E. Heywood, Hakam Abbass, Aderonke Abiodun, Mashael Alfarih, Zoe Alldis, Oliver E. Amin, Mervyn Andiapen, Jessica Artico, João B. Augusto, Georgina L. Baca, Sasha N.L. Bailey, Anish N. Bhuva, Alex Boulter, Ruth Bowles, Olivia V. Bracken, Ben O’Brien, Natalie Bullock, David K. Butler, Olivia Carr, Nicola Champion, Carmen Chan, Aneesh Chandran, Tom Coleman, Jorge Couto de Sousa, Xose Couto-Parada, Eleanor Cross, Teresa Cutino-Moguel, Silvia D’Arcangelo, Rhodri H. Davies, Brooke Douglas, Cecilia Di Genova, Keenan Dieobi-Anene, Mariana O. Diniz, Anaya Ellis, Karen Feehan, Malcolm Finlay, Nasim Forooghi, Sasha Francis, David Gillespie, Derek Gilroy, Matt Hamblin, Gabrielle Harker, Georgia Hemingway, Jacqueline Hewson, Wendy Heywood, Lauren M. Hickling, Bethany Hicks, Aroon D. Hingorani, Lee Howes, Ivie Itua, Victor Jardim, Wing-Yiu Jason Lee, Melaniepetra Jensen, Jessica Jones, Meleri Jones, George Joy, Vikas Kapil, Caoimhe Kelly, Hibba Kurdi, Jonathan Lambourne, Kai-Min Lin, Siyi Liu, Aaron Lloyd, Sarah Louth, Vineela Mandadapu, Katia Menacho, Celina Mfuko, Sebastian Millward, Oliver Mitchelmore, Christopher Moon, James Moon, Diana Muñoz Sandoval, Sam M. Murray, Ashley Otter, Susana Palma, Ruth Parker, Kush Patel, Mihaela Pawarova, Steffen E. Petersen, Brian Piniera, Franziska P. Pieper, Lisa Rannigan, Alicja Rapala, Amy Richards, Matthew Robathan, Joshua Rosenheim, Cathy Rowe, Matthew Royds, Jane Sackville West, Genine Sambile, Nathalie M. Schmidt, Hannah Selman, Andreas Seraphim, Mihaela Simion, Angelique Smit, Michelle Sugimoto, Leo Swadling, Stephen Taylor, Nigel Temperton, Stephen Thomas, George D. Thornton, Thomas A. Treibel, Art Tucker, Ann Varghese, Jessry Veerapen, Mohit Vijayakumar, Tim Warner, Sophie Welch, Hannah White, Theresa Wodehouse, Lucinda Wynne, Dan Zahedi

Publikováno v: Cell Reports: Methods, Vol 2, Iss 9, Pp 100279- (2022)

Summary: Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immune

Externí odkaz: https://doaj.org/article/9be530f264774b93a8869c019914391d

Isolation of human intrahepatic leukocytes for phenotypic and functional characterization by flow cytometry

Autor: Stephanie Kucykowicz, Oliver E. Amin, Alice R. Burton, Leo Swadling, Nathalie M. Schmidt, Nekisa Zakeri, Jessica Davies, Gloryanne Aidoo-Micah, Kerstin A. Stegmann, Nicholas J. Easom, Anna Jeffery-Smith, Mala K. Maini, Laura J. Pallett

Publikováno v: STAR Protocols, Vol 3, Iss 2, Pp 101356- (2022)

Summary: With the growing appreciation of tissue-resident immunity, studying tissue-specific immune cells contributing to both homeostasis and disease is imperative. Here, we provide a protocol for the isolation of human intrahepatic leukocytes (IHL)

Externí odkaz: https://doaj.org/article/45abae595f3b493592066ff2dfbe21a4

Inference of the SARS-CoV-2 generation time using UK household data

Autor: William S Hart, Sam Abbott, Akira Endo, Joel Hellewell, Elizabeth Miller, Nick Andrews, Philip K Maini, Sebastian Funk, Robin N Thompson

Publikováno v: eLife, Vol 11 (2022)

The distribution of the generation time (the interval between individuals becoming infected and transmitting the virus) characterises changes in the transmission risk during SARS-CoV-2 infections. Inferring the generation time distribution is essenti

Externí odkaz: https://doaj.org/article/0eb98f1e600a44449f9731b88eddd52d