Zobrazeno 1 - 10
of 196
pro vyhledávání: '"A. Joshua Wand"'
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1338 (2024)
Mutations in the parkin gene product Parkin give rise to autosomal recessive juvenile parkinsonism. Parkin is an E3 ubiquitin ligase that is a critical participant in the process of mitophagy. Parkin has a complex structure that integrates several al
Externí odkaz:
https://doaj.org/article/6b6946331d7443fdbbb5d5c127c6f547
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The authors present BARASA, an approach to assign backbone triple resonance spectra of proteins that augments traditional approaches with a Bayesian statistical analysis of the observed chemical shifts. The algorithm employs a simulated annealing eng
Externí odkaz:
https://doaj.org/article/b8c804182311451eb70bca6041e4fffb
Autor:
A. Joshua Wand
Publikováno v:
Structural Dynamics, Vol 10, Iss 2, Pp 020901-020901-4 (2023)
For over half a century, it has been known that protein molecules naturally undergo extensive structural fluctuations, and that these internal motions are intimately related to their functional properties. The energy landscape view has provided a pow
Externí odkaz:
https://doaj.org/article/4e334a34825a4878b3cffd5b75eedc5f
Publikováno v:
Biophysical Reports, Vol 3, Iss 1, Pp 100098- (2023)
The thermodynamics of molecular recognition by proteins is a central determinant of complex biochemistry. For over a half-century, detailed cryogenic structures have provided deep insight into the energetic contributions to ligand binding by proteins
Externí odkaz:
https://doaj.org/article/69eae41ec89b401abf3ade8765988f6c
Autor:
Duncan W. S. MacKenzie, Anna Schaefer, Julia Steckner, Christopher A. Leo, Dalia Naser, Efrosini Artikis, Aron Broom, Travis Ko, Purnank Shah, Mikaela Q. Ney, Elisa Tran, Martin T. J. Smith, Brian Fuglestad, A. Joshua Wand, Charles L. Brooks, Elizabeth M. Meiering
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(26)
Allostery is the phenomenon of coupling between distal binding sites in a protein. Such coupling is at the crux of protein function and regulation in a myriad of scenarios, yet determining the molecular mechanisms of coupling networks in proteins rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10fd9ff87b67f2d00a12c2f70002d74
https://pubmed.ncbi.nlm.nih.gov/35737838
https://pubmed.ncbi.nlm.nih.gov/35737838
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c07682323671b2ae0b15b4314ed2ab4
https://pubmed.ncbi.nlm.nih.gov/34288674
https://pubmed.ncbi.nlm.nih.gov/34288674
Publikováno v:
ACS Chem Biol
Very weak interactions between small organic molecules and proteins have long been predicted and are expected to have dissociation constants of hundreds of millimolar and above. Unfortunately, quantitative evaluation of binding in a high-resolution s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445a9fa89a7296bfd5ad7a5086db7479
https://doi.org/10.1021/acschembio.9b00353
https://doi.org/10.1021/acschembio.9b00353
Autor:
Catherine A. Royer, Amanda S. Byer, Nozomi Ando, Richard E. Gillilan, Blanca Barquera, Eric S. Boyd, Martin Gruebele, Everett L. Shock, George I. Makhatadze, Daniel R. Colman, A. Joshua Wand, Douglas H. Bartlett, Audrey A. Burnim, Maxwell B. Watkins
Publikováno v:
Annual review of biophysics. 50
Sampling and genomic efforts over the past decade have revealed an enormous quantity and diversity of life in Earth's extreme environments. This new knowledge of life on Earth poses the challenge of understandingits molecular basis in such inhospitab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a72dd996abdec5bdc15b1e36398436c
https://pubmed.ncbi.nlm.nih.gov/33637008
https://pubmed.ncbi.nlm.nih.gov/33637008
Autor:
Trevor M. Penning, Gregory D. Van Duyne, Irfan A. Asangani, A. Joshua Wand, Vincent J. Hilser, Ian A. Blair, Vera Y. Moiseenkova-Bell, Cynthia C. Sprenger, Stephen R. Plymate
Publikováno v:
The Journal of Biological Chemistry
Castration resistant prostate cancer (CRPC) continues to be androgen receptor (AR) driven. Inhibition of AR signaling in CRPC could be advanced using state-of-the-art biophysical and biochemical techniques. Structural characterization of AR and its c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604026f0eb231823b774b11f3348def9
http://europepmc.org/articles/PMC7949100
http://europepmc.org/articles/PMC7949100
Publikováno v:
In Journal of Magnetic Resonance 2008 195(2):169-178