Zobrazeno 1 - 10
of 19
pro vyhledávání: '"A. Jacqueline Hunter"'
Autor:
Yuyan Chen, Mark Pinese, Claire Wakefield, Frank Alvaro, Katherine Tucker, Tracey A O’Brien, Vanessa J Tyrrell, Judy Kirk, Kate Hetherington, Eliza Courtney, Kristine Barlow-Stewart, Noemi Auxiliadora Fuentes Bolanos, Bhavna Padhye, Macabe Daley, Jacqueline Hunter, Meera Warby, Sarah Josephi-Taylor, Marie Wong-Erasmus, Paulette Barahona, Pamela Ajuyah, Ann-Kristin Altekoester, Loretta M S Lau, Dianne Sylvester, Luciano Dalla Pozza
Publikováno v:
BMJ Open, Vol 13, Iss 5 (2023)
Introduction Identifying an underlying germline cancer predisposition (CP) in a child with cancer has potentially significant implications for both the child and biological relatives. Cohort studies indicate that 10%–15% of paediatric cancer patien
Externí odkaz:
https://doaj.org/article/da226946131d4fd0bb6f8385a8b6d90d
Autor:
M Browne, A. Haynes, Vesna Mijat, Liz Bentley, Michelle Goldsworthy, Lee Moir, Alison Hugill, A. Jacqueline Hunter, Nigel K. Spurr, Julie Quarterman, Roger D. Cox, Tertius Hough, A. A. Toye
Publikováno v:
Diabetes. 53:1577-1583
Here we report the first cloned N-ethyl-nitrosourea (ENU)-derived mouse model of diabetes. GENA348 was identified through free-fed plasma glucose measurement, being more than 2 SDs above the population mean of a cohort of >1,201 male ENU mutant mice.
Publikováno v:
Expert Opinion on Emerging Drugs. 8:103-122
Stroke is the third leading cause of death and the leading cause of disability in developed countries, yet remains a poorly treated condition. Treatments for stroke can be aimed at acutely improving blood flow or protecting brain tissue against ischa
Autor:
A. Jacqueline Hunter, Declan N.C. Jones, Drake S. Eggleston, S J Bolton, John G. Darker, Frank S. Walsh
Publikováno v:
European Journal of Neuroscience. 12:2847-2855
Investigation of normal and pathological diseases of the central nervous system (CNS) has been hampered by the inability to effectively manipulate protein function in vivo. In order to address this important topic, we have evaluated the ability of pe
Autor:
Karen L Murkitt, Derek N. Middlemiss, Michael Ho, A. Jacqueline Hunter, F. Brown, Jeannette M. Watson, Martyn D. Wood
Publikováno v:
British Journal of Pharmacology. 126:1620-1624
1. This study describes the pharmacological comparison of the muscarinic partial agonists sabcomeline, xanomeline and milameline at human cloned muscarinic receptor subtypes (hM1-5). 2. Radioligand binding studies at the hM1-5 muscarinic receptor sub
Autor:
Sohaila Rastan, Tertius Hough, Amy Kierman, Rachel Hardisty, Alexandra Erven, Ian C. Gray, Stepanie Voeling, Adrian Isaacs, Hsun Tsai, Mark Strivens, Rebecca Washbourne, Claire Thornton, Simon Greenaway, Mazda Hewitt, Stefan McCormick, Rachael Selley, Christine Wells, Zuzanna Tymowska-Lalanne, Phil Roby, Philomena Mburu, Derek Rogers, Jim Hagan, Charlie Reavill, Kay Davies, Peter Glenister, Elizabeth M. C. Fisher, Josephine Martin, Lucy Vizor, Mark Bouzyk, David Kelsell, Jean-Louis Gue´net, Karen P. Steel, Steve Sheardown, Nigel Spurr, Ian Gray, Jo Peters, Patrick M. Nolan, A. Jacqueline Hunter, Steve D. M. Brown
Publikováno v:
Mutagenesis of the Mouse Genome ISBN: 9781402028755
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34aac9c86aa99aa86e51736024f5ba49
https://doi.org/10.1007/978-1-4020-5057-2_5
https://doi.org/10.1007/978-1-4020-5057-2_5
Autor:
Rabinder Kumar Prinjha, Allen D. Roses, Steven M. Fox, Nikos Tsokanas, John Yates, Marjorie A. Smith, Wen Wu, Israel S. Gloger, Jill C. Richardson, Wanda M. Bodnar, Joanna D. Holbrook, Paul Cutler, Christine Debouck, Emma L. Akuffo, A. Jacqueline Hunter, Emma E. Kinsey, Rachel A. Gibson, Darren A. Gormley, David R. Willé, Deborah M. Briggs, John B. Davis
Publikováno v:
Proteomics. Clinical applications. 2(4)
Emerging disease modifying therapeutic strategies for Alzheimer's disease (AD) have generated a critical need for biomarkers of early stage disease. Here, we describe the identification and assessment of a number of candidate biomarkers in patients w
Publikováno v:
Behavioural brain research. 155(2)
The use of transgenic models in scientific research has made an enormous contribution to our understanding of the causes and symptoms of many diseases, including neurodegenerative conditions such as Alzheimer’s Disease (AD) and Parkinson’s Diseas
Autor:
Sian Clements, Elizabeth M. C. Fisher, Sohaila Rastan, Ian C. Gray, Roger D. Cox, A. Jacqueline Hunter, Josephine Peters, Patrick M. Nolan, Joanne E. Martin, Nigel K. Spurr, Peter H. Glenister, Tertius Hough, Vicky Tsipouri, Lee Moir, Mark A. Strivens, Rachael L. Selley, Steve D.M. Brown, Michelle Goldsworthy, A. A. Toye, Lucie Vizor, Stefan L. McCormack, John Wood
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 13(10)
We used ENU mutagenesis in the mouse for the rapid generation of novel mutant phenotypes for both gene function studies and use as new animal models of human disease (Nolan et al. 2000b). One focus of the program was the development of a blood bioche
Autor:
Ann Jacqueline Hunter
Publikováno v:
Annals of the New York Academy of Sciences. 1245:1-2
Animal models have played an important role in target validation, screening of compounds for efficacy and optimization of pharmacokinetic properties and toxicological testing. However, new paradigms for drug discovery and development will require a g