Zobrazeno 1 - 5
of 5
pro vyhledávání: '"A. J. Willmer-Hulme"'
Autor:
Timothy Vollmer, William A. Sheremata, Paul O'Connor, A. J. Willmer-Hulme, Andrew D. Goodman, M. A. Libonati, Luanne M. Metz, Lael Stone, R. S. Murray
Publikováno v:
Neurology. 62:2038-2043
Relapses in multiple sclerosis (MS) can cause significant neurologic disability. Natalizumab (Antegren) is a humanized anti-alpha4-integrin antibody that inhibits the trafficking of leukocytes across endothelium by blocking binding of alpha4beta1-int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a769b06cab6874c33169777c7eae255
https://doi.org/10.1212/01.wnl.0000128136.79044.d6
https://doi.org/10.1212/01.wnl.0000128136.79044.d6
Publikováno v:
International Journal of MS Care. 2:2-5
Anti-alpha4 integrin antibody, natalizumab (Antegren), is a monoclonal antibody to a4b1 integrin adhesion molecules expressed on activated monocytes and CD4 cells. A 1-year followup of 28 patients with relapsing multiple sclerosis, randomized to 3 gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155dff8b4ce818aeb0aad5ff096b9eb7
https://doi.org/10.7224/1537-2073-2.1.2
https://doi.org/10.7224/1537-2073-2.1.2
Autor:
Michele A Libonati, David Miller, Lance D Blumhardt, William A. Sheremata, Allison J Willmer-Hulme, Paul O'Connor, Catherine M. Dalton, Omar Khan, Katherine A. Miszkiel, George P.A. Rice
Publikováno v:
The New England journal of medicine. 348(1)
In patients with multiple sclerosis, inflammatory brain lesions appear to arise from autoimmune responses involving activated lymphocytes and monocytes. The glycoprotein alpha4 integrin is expressed on the surface of these cells and plays a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c895e62901291e50cd05f523d055ee
https://pubmed.ncbi.nlm.nih.gov/12700382
https://pubmed.ncbi.nlm.nih.gov/12700382
Autor:
Mark F. Lew, Cynthia L. Comella, Mitchell F. Brin, A. J. Willmer-Hulme, Dennis D. Dykstra, Allison Brashear, J. D. Wallace, Carlos Singer, M. Koller, J. J. Murray, Stewart A. Factor, Richard Trosch, Robert L. Rodnitzky
Publikováno v:
Neurology. 53(7)
To determine the safety and efficacy of botulinum toxin type B (BoNT/B) in patients with type A-resistant cervical dystonia (CD).Local intramuscular injections of BoNT are an effective therapy for CD. After repeated use, some patients become resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16277c3713a06d0c9eb7d1017549621
https://pubmed.ncbi.nlm.nih.gov/10534247
https://pubmed.ncbi.nlm.nih.gov/10534247
Publikováno v:
Neurology. 52:1072-1072
A phase 1, randomized, placebo-controlled, five-level dose escalation safety and tolerability and pharmacokinetic study of a single IV dose of natalizumab was performed. Doses of 0.03 to 3.0 mg/kg natalizumab or placebo were studied in 28 stable rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6155cd7cda4000e9f4a099f87f3ed0
https://doi.org/10.1212/wnl.52.5.1072
https://doi.org/10.1212/wnl.52.5.1072