Zobrazeno 1 - 10
of 1 674
pro vyhledávání: '"A. J. Welsh"'
Autor:
Georg Krainer, Raphael P. B. Jacquat, Matthias M. Schneider, Timothy J. Welsh, Jieyuan Fan, Quentin A. E. Peter, Ewa A. Andrzejewska, Greta Šneiderienė, Magdalena A. Czekalska, Hannes Ausserwoeger, Lin Chai, William E. Arter, Kadi L. Saar, Therese W. Herling, Titus M. Franzmann, Vasilis Kosmoliaptsis, Simon Alberti, F. Ulrich Hartl, Steven F. Lee, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The physical characterization of proteins in terms of their sizes, interactions, and assembly states is key to understanding their biological function and dysfunction. However, this has remained a difficult task because proteins are often hi
Externí odkaz:
https://doaj.org/article/a359ec4607614996aebacbbb2897fd7b
Autor:
Ines Horvat-Menih, Hao Li, Andrew N. Priest, Shaohang Li, Andrew B. Gill, Iosif A. Mendichovszky, Susan T. Francis, Anne Y. Warren, Brent O’Carrigan, Sarah J. Welsh, James O. Jones, Antony C. P. Riddick, James N. Armitage, Thomas J. Mitchell, Grant D. Stewart, Ferdia A. Gallagher
Publikováno v:
European Radiology Experimental, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract Background Clinical imaging tools to probe aggressiveness of renal masses are lacking, and T2-weighted imaging as an integral part of magnetic resonance imaging protocol only provides qualitative information. We developed high-resolution and
Externí odkaz:
https://doaj.org/article/b6c4ff0758a645e8b1e1748405028287
Autor:
Mrityunjoy Kar, Laura T. Vogel, Gaurav Chauhan, Suren Felekyan, Hannes Ausserwöger, Timothy J. Welsh, Furqan Dar, Anjana R. Kamath, Tuomas P. J. Knowles, Anthony A. Hyman, Claus A. M. Seidel, Rohit V. Pappu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Phase separation and percolation contribute to phase transitions of multivalent macromolecules. Contributions of percolation are evident through the viscoelasticity of condensates and through the formation of heterogeneous distributions of n
Externí odkaz:
https://doaj.org/article/12c6a6e070804665adbd0503a07d444e
Autor:
Thomas J Mitchell, Hao Li, Grant D Stewart, Anne Y Warren, James N Armitage, Ferdia A Gallagher, Mary A McLean, Andrew N Priest, Andrew B Gill, Iosif Mendichovszky, João Duarte, Ines Horvat-Menih, Maria Jesus Zamora-Morales, Marta Wylot, Joshua Kaggie, Alixander S Khan, Matthew J Locke, Sarah J Welsh, James O Jones
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Introduction Localised renal masses are an increasing burden on healthcare due to the rising number of cases. However, conventional imaging cannot reliably distinguish between benign and malignant renal masses, and renal mass biopsies are unable to c
Externí odkaz:
https://doaj.org/article/90752ec8113d439d8fdb872d49956c6c
Publikováno v:
Artificial Intelligence Chemistry, Vol 2, Iss 1, Pp 100040- (2024)
The orexin 1 receptor (OX1R) is a G-protein coupled receptor that regulates a variety of physiological processes through interactions with the neuropeptides orexin A and B. Selective OX1R antagonists exhibit therapeutic effects in preclinical models
Externí odkaz:
https://doaj.org/article/a4e59885beaf4219963705c995b0d978
Autor:
Tomas Sneideris, Nadia A. Erkamp, Hannes Ausserwöger, Kadi L. Saar, Timothy J. Welsh, Daoyuan Qian, Kai Katsuya-Gaviria, Margaret L. L. Y. Johncock, Georg Krainer, Alexander Borodavka, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Antimicrobial peptides (AMPs), which combat bacterial infections by disrupting the bacterial cell membrane or interacting with intracellular targets, are naturally produced by a number of different organisms, and are increasingly also explor
Externí odkaz:
https://doaj.org/article/f347a58e300d44799db612aff9c099ee
Autor:
Georg Dorn, Christoph Gmeiner, Tebbe de Vries, Emil Dedic, Mihajlo Novakovic, Fred F. Damberger, Christophe Maris, Esteban Finol, Chris P. Sarnowski, Joachim Kohlbrecher, Timothy J. Welsh, Sreenath Bolisetty, Raffaele Mezzenga, Ruedi Aebersold, Alexander Leitner, Maxim Yulikov, Gunnar Jeschke, Frédéric H.-T. Allain
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract RNA-binding proteins (RBPs) are crucial regulators of gene expression, often composed of defined domains interspersed with flexible, intrinsically disordered regions. Determining the structure of ribonucleoprotein (RNP) complexes involving s
Externí odkaz:
https://doaj.org/article/6ecfd082137440199e61e0254d4f1997
Autor:
Rachel C M Brierley, Jodi Taylor, Nicholas Turner, Sophie Rees, Joanna Thorn, Chris Metcalfe, Emily J Henderson, Clare Clement, Tomas J Welsh, Karen Sargent, Gemma Morgan, Derren Ready, Dominic Mellon, Liping Wen, Ruth Kipping, Alastair D Hay
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0304488 (2024)
BackgroundRespiratory tract infections are readily transmitted in care homes. Airborne transmission of pathogens causing respiratory tract illness is largely unmitigated. Portable high-efficiency-particulate-air (HEPA) filtration units capture microb
Externí odkaz:
https://doaj.org/article/f5b25641d6ae46b1ade3785ea1cf2bc9
Autor:
Georg Krainer, Kadi L. Saar, William E. Arter, Timothy J. Welsh, Magdalena A. Czekalska, Raphaël P. B. Jacquat, Quentin Peter, Walther C. Traberg, Arvind Pujari, Akhila K. Jayaram, Pavankumar Challa, Christopher G. Taylor, Lize-Mari van der Linden, Titus Franzmann, Roisin M. Owens, Simon Alberti, David Klenerman, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
There are limitations with current protein sensing methods. Here the authors report DigitISA, a digital immunosensor assay based on microchip electrophoretic separation and single-molecule detection that enables quantitation of protein biomarkers in
Externí odkaz:
https://doaj.org/article/1dd14b1c42c546e0b4a6295b18856433
Autor:
Kiarash Shirbandi, Mohammad Khalafi, Joseph J Bevelacqua, Najmeh Sadeghian, Saina Adiban, Faegheh Bahaeddini Zarandi, Seyed Alireza Mortazavi, Seyedeh Hanieh Mortazavi, Seyed Mohammad Javad Mortazavi, James J Welsh
Publikováno v:
Journal of Biomedical Physics and Engineering, Vol 13, Iss 1, Pp 3-16 (2023)
Background: Alzheimer’s disease (AD) is one of the most significant public health concerns and tremendous economic challenges. Studies conducted over the past decades show that exposure to radiofrequency electromagnetic fields (RF-EMFs) may relieve
Externí odkaz:
https://doaj.org/article/ba2e4f272ed045cb972a93ee24bb1be7