Zobrazeno 1 - 10
of 1 832
pro vyhledávání: '"A. J. Waters"'
Publikováno v:
Ocean Science, Vol 20, Pp 1657-1676 (2024)
Satellite altimeter measurements of sea surface height (SSH) are a crucial component of current operational ocean forecasting systems. The launch of the Surface Water and Ocean Topography (SWOT) wide-swath altimeter (WiSA) mission is bringing a step
Externí odkaz:
https://doaj.org/article/84fc190b7ffb4d3281af349d5458a23f
Publikováno v:
JIMD Reports, Vol 65, Iss 6, Pp 433-441 (2024)
Abstract Glutaric aciduria type 1 (GA1) is an inherited neurometabolic disorder, in which deficiency of glutaryl‐CoA dehydrogenase leads to accumulation of glutaric acid (GA) and 3‐hydroxyglutaric acid (3‐HG). Some low excretors may exhibit onl
Externí odkaz:
https://doaj.org/article/b014b0ec9efc4fb6b585fa913d9cfcbc
Autor:
Heather Pekeles, Saoussen Berrahmoune, Christelle Dassi, Anthony C.T. Cheung, Tommy Gagnon, Paula J. Waters, Ralf Eberhard, Daniela Buhas, Kenneth A. Myers
Publikováno v:
EClinicalMedicine, Vol 74, Iss , Pp 102740- (2024)
Summary: Background: DNA polymerase gamma (POLG)-related disorders are a group of rare neurodegenerative mitochondrial diseases caused by pathogenic variants in POLG, the gene encoding POLG. Patients may experience a range of signs and symptoms, incl
Externí odkaz:
https://doaj.org/article/5c771b201fc2471fa8c75fd0226fc779
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32424- (2024)
Current in vitro biofilm modelling of the opportunistic pathogen, Pseudomonas aeruginosa (PA) in people with cystic fibrosis (PwCF) is limited in its ability to mimic the complexities of the cystic fibrosis (CF) lung environment. Recent adaptations o
Externí odkaz:
https://doaj.org/article/34c867b999054a56aaba6ec84716f0a4
Autor:
Elizabeth J. Radford, Hong-Kee Tan, Malin H. L. Andersson, James D. Stephenson, Eugene J. Gardner, Holly Ironfield, Andrew J. Waters, Daniel Gitterman, Sarah Lindsay, Federico Abascal, Iñigo Martincorena, Anna Kolesnik-Taylor, Elise Ng-Cordell, Helen V. Firth, Kate Baker, John R. B. Perry, David J. Adams, Sebastian S. Gerety, Matthew E. Hurles
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Loss-of-function of DDX3X is a leading cause of neurodevelopmental disorders (NDD) in females. DDX3X is also a somatically mutated cancer driver gene proposed to have tumour promoting and suppressing effects. We perform saturation genome edi
Externí odkaz:
https://doaj.org/article/787606f0736b45d2b045e1283e0cd595
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract Mathematical models to predict skin permeation tend to be based on animal derived experimental data as well as knowing physicochemical properties of the compound under investigation, such as molecular volume, polarity and lipophilicity. This
Externí odkaz:
https://doaj.org/article/b2f951ca8f89490191d1cdf2709efc6c
Publikováno v:
Animals, Vol 14, Iss 17, p 2608 (2024)
Emerging evidence in women supports the notion that pregnancy may reset disease resistance, thereby providing protection against subsequent adverse health outcomes, but this hypothesis has not been adequately explored in domestic dogs. Cranial crucia
Externí odkaz:
https://doaj.org/article/267c9ce3ae72470290d9cddd62571f59
Autor:
David J. Waters, Rong Fu, Andres E. Carrillo, Emily C. Chiang, Aimee H. Maras, Seema S. Kengeri, Cheri L. Suckow
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Cranial cruciate ligament (CCL) rupture is one of the most commonly diagnosed orthopedic conditions of pet dogs, making estimated lifetime cruciate ligament survival an attractive endpoint for studies attempting to define clinical and geneti
Externí odkaz:
https://doaj.org/article/c4fe36ff97814d4ba79b871f1d4ee2ff
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e21712- (2023)
Protein stability is fundamental to maintain pharmaceutical efficacy in the nascent field of biologics. One particular property that is essential for therapeutic effect is retention of the folded 3-dimensional conformation, i.e. once unfolding has oc
Externí odkaz:
https://doaj.org/article/ae870c1aa3ba411296fee1162e5dc82b
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionTobacco smoking is a leading cause of preventable death worldwide. The perinatal period provides a unique opportunity for intervention, as many smokers quit smoking during pregnancy but relapse postpartum. Novel relapse prevention interve
Externí odkaz:
https://doaj.org/article/8c3be58968e64839a0b7b331e9f2fe16