Zobrazeno 1 - 10
of 323
pro vyhledávání: '"A. J. Turley"'
Autor:
Alessandra Castiglioni, Yagai Yang, Katherine Williams, Alvin Gogineni, Ryan S. Lane, Amber W. Wang, Justin A. Shyer, Zhe Zhang, Stephanie Mittman, Alan Gutierrez, Jillian L. Astarita, Minh Thai, Jeffrey Hung, Yeqing Angela Yang, Tony Pourmohamad, Patricia Himmels, Marco De Simone, Justin Elstrott, Aude-Hélène Capietto, Rafael Cubas, Zora Modrusan, Wendy Sandoval, James Ziai, Stephen E. Gould, Wenxian Fu, Yulei Wang, James T. Koerber, Shomyseh Sanjabi, Ira Mellman, Shannon J. Turley, Sören Müller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanced cancers, particularly in the immune-excluded phenotype. While previous work demonstrates that converting tumors from excluded to inflamed
Externí odkaz:
https://doaj.org/article/fa5b40b8c1aa4ad3abed292446b9c3af
Autor:
Jillian L. Astarita, Shilpa Keerthivasan, Bushra Husain, Yasin Şenbabaoğlu, Erik Verschueren, Sarah Gierke, Victoria C. Pham, Sean M. Peterson, Cecile Chalouni, Andrew A. Pierce, Jennie R. Lill, Lino C. Gonzalez, Nadia Martinez-Martin, Shannon J. Turley
Publikováno v:
PLoS ONE, Vol 16, Iss 12 (2021)
The cancer-associated fibroblast (CAF) marker podoplanin (PDPN) is generally correlated with poor clinical outcomes in cancer patients and thus represents a promising therapeutic target. Despite its biomedical relevance, basic aspects of PDPN biology
Externí odkaz:
https://doaj.org/article/87b716521ce444d8bffa72f85fd9fcc7
Autor:
Anna S. Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, Matthew B. Buechler, Steve Lianoglou, Varun N. Kapoor, Maria E. Johansson, Johan B. Fagman, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Bo T. Porse, Antonius G. Rolink, Hans Nissbrandt, Shannon J. Turley, Hans Carlsten, Inga-Lill Mårtensson, Mikael C. I. Karlsson, Åsa Tivesten
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticula
Externí odkaz:
https://doaj.org/article/d1f804563c204b959332c0cb6ac7f78d
Autor:
Akshay T. Krishnamurty, Justin A. Shyer, Minh Thai, Vineela Gandham, Matthew B. Buechler, Yeqing Angela Yang, Rachana N. Pradhan, Amber W. Wang, Patricia L. Sanchez, Yan Qu, Beatrice Breart, Cécile Chalouni, Debra Dunlap, James Ziai, Justin Elstrott, Neelie Zacharias, Weiguang Mao, Rebecca K. Rowntree, Jack Sadowsky, Gail D. Lewis, Thomas H. Pillow, Barzin Y. Nabet, Romain Banchereau, Lucinda Tam, Roger Caothien, Natasha Bacarro, Merone Roose-Girma, Zora Modrusan, Sanjeev Mariathasan, Sören Müller, Shannon J. Turley
Publikováno v:
Nature. 611:148-154
Recent single-cell studies of cancer in both mice and humans have identified the emergence of a myofibroblast population specifically marked by the highly restricted leucine-rich-repeat-containing protein 15 (LRRC15)1–3. However, the molecular sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1180240064ddca96a7dbfb51299c508a
https://doi.org/10.1038/s41586-022-05272-1
https://doi.org/10.1038/s41586-022-05272-1
Autor:
Nikolaos Chatziandreou, Yagmur Farsakoglu, Miguel Palomino-Segura, Rocco D’Antuono, Diego Ulisse Pizzagalli, Federica Sallusto, Veronika Lukacs-Kornek, Mariagrazia Uguccioni, Davide Corti, Shannon J. Turley, Antonio Lanzavecchia, Michael C. Carroll, Santiago F. Gonzalez
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2427-2440 (2017)
The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vacci
Externí odkaz:
https://doaj.org/article/934b53f8cf8d45b48b75e2ddcf954ded
Autor:
John A. Grout, Philemon Sirven, Andrew M. Leader, Shrisha Maskey, Eglantine Hector, Isabelle Puisieux, Fiona Steffan, Evan Cheng, Navpreet Tung, Mathieu Maurin, Romain Vaineau, Lea Karpf, Martin Plaud, Anne-Laure Begue, Koushik Ganesh, Jérémy Mesple, Maria Casanova-Acebes, Alexandra Tabachnikova, Shilpa Keerthivasan, Alona Lansky, Jessica Le Berichel, Laura Walker, Adeeb H. Rahman, Sacha Gnjatic, Nicolas Girard, Marine Lefevre, Diane Damotte, Julien Adam, Jerome C. Martin, Andrea Wolf, Raja M. Flores, Mary Beth Beasley, Rachana Pradhan, Soren Muller, Thomas U. Marron, Shannon J. Turley, Miriam Merad, Ephraim Kenigsberg, Hélène Salmon
Publikováno v:
Cancer Discovery. 12:2606-2625
It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors. We identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e8ef2a76c5961ac4b575edec96e4ec
https://doi.org/10.1158/2159-8290.cd-21-1714
https://doi.org/10.1158/2159-8290.cd-21-1714
Autor:
Guadalupe Ortiz-Muñoz, Markus Brown, Catherine B. Carbone, Ximo Pechuan-Jorge, Vincent Rouilly, Henrik Lindberg, Alex T. Ritter, Gautham Raghupathi, Qianbo Sun, Tess Nicotra, Shreya R. Mantri, Angela Yang, Jonas Doerr, Deepti Nagarkar, Spyros Darmanis, Benjamin Haley, Sanjeev Mariathasan, Yulei Wang, Carlos Gomez-Roca, Carlos Eduardo de Andrea, David Spigel, Thomas Wu, Lelia Delamarre, Johannes Schöneberg, Zora Modrusan, Richard Price, Shannon J. Turley, Ira Mellman, Christine Moussion
Publikováno v:
Nature.
The immune phenotype of a tumour is a key predictor of its response to immunotherapy1–4. Patients who respond to checkpoint blockade generally present with immune-inflamed5–7 tumours that are highly infiltrated by T cells. However, not all inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8538c3f5c22f9717c1cbbb9f3b2027c
https://doi.org/10.1038/s41586-023-06132-2
https://doi.org/10.1038/s41586-023-06132-2
Autor:
Hélène Salmon, Ephraim Kenigsberg, Miriam Merad, Shannon J. Turley, Thomas U. Marron, Soren Muller, Rachana Pradhan, Mary Beth Beasley, Raja M. Flores, Andrea Wolf, Jerome C. Martin, Julien Adam, Diane Damotte, Marine Lefevre, Nicolas Girard, Sacha Gnjatic, Adeeb H. Rahman, Laura Walker, Jessica Le Berichel, Alona Lansky, Shilpa Keerthivasan, Alexandra Tabachnikova, Maria Casanova-Acebes, Jérémy Mesple, Koushik Ganesh, Anne-Laure Begue, Martin Plaud, Lea Karpf, Romain Vaineau, Mathieu Maurin, Navpreet Tung, Evan Cheng, Fiona Steffan, Isabelle Puisieux, Eglantine Hector, Shrisha Maskey, Andrew M. Leader, Philemon Sirven, John A. Grout
Supplementary Figure from Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8703b6a28ad25f45d12d647457ede2f3
https://doi.org/10.1158/2159-8290.22541772.v1
https://doi.org/10.1158/2159-8290.22541772.v1
Autor:
Hélène Salmon, Ephraim Kenigsberg, Miriam Merad, Shannon J. Turley, Thomas U. Marron, Soren Muller, Rachana Pradhan, Mary Beth Beasley, Raja M. Flores, Andrea Wolf, Jerome C. Martin, Julien Adam, Diane Damotte, Marine Lefevre, Nicolas Girard, Sacha Gnjatic, Adeeb H. Rahman, Laura Walker, Jessica Le Berichel, Alona Lansky, Shilpa Keerthivasan, Alexandra Tabachnikova, Maria Casanova-Acebes, Jérémy Mesple, Koushik Ganesh, Anne-Laure Begue, Martin Plaud, Lea Karpf, Romain Vaineau, Mathieu Maurin, Navpreet Tung, Evan Cheng, Fiona Steffan, Isabelle Puisieux, Eglantine Hector, Shrisha Maskey, Andrew M. Leader, Philemon Sirven, John A. Grout
Supplementary Table from Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00031f7fd3da6dccf6c6a6be337b155b
https://doi.org/10.1158/2159-8290.22541733.v1
https://doi.org/10.1158/2159-8290.22541733.v1
Autor:
Hélène Salmon, Ephraim Kenigsberg, Miriam Merad, Shannon J. Turley, Thomas U. Marron, Soren Muller, Rachana Pradhan, Mary Beth Beasley, Raja M. Flores, Andrea Wolf, Jerome C. Martin, Julien Adam, Diane Damotte, Marine Lefevre, Nicolas Girard, Sacha Gnjatic, Adeeb H. Rahman, Laura Walker, Jessica Le Berichel, Alona Lansky, Shilpa Keerthivasan, Alexandra Tabachnikova, Maria Casanova-Acebes, Jérémy Mesple, Koushik Ganesh, Anne-Laure Begue, Martin Plaud, Lea Karpf, Romain Vaineau, Mathieu Maurin, Navpreet Tung, Evan Cheng, Fiona Steffan, Isabelle Puisieux, Eglantine Hector, Shrisha Maskey, Andrew M. Leader, Philemon Sirven, John A. Grout
It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors. We identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345b8d50748817952a44758bb1b8fd57
https://doi.org/10.1158/2159-8290.c.6549735
https://doi.org/10.1158/2159-8290.c.6549735