A Facile Method to Produce N-Terminally Truncated α-Synuclein

Autor: Rebecca J. Thrush, Devkee M. Vadukul, Francesco A. Aprile

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

α-Synuclein is a key protein of the nervous system, which regulates the release and recycling of neurotransmitters in the synapses. It is also involved in several neurodegenerative conditions, including Parkinson’s disease and Multiple System Atro

Externí odkaz: https://doaj.org/article/c4b919db269444c5b2c2cdcfba9c5ff9

Bainite kinetic transformation of austempered AISI 6150 steel

Autor: Xue Han, Zhenpu Zhang, Yanhao Rong, Steven J. Thrush, Gary C. Barber, Hongyu Yang, Feng Qiu

Publikováno v: Journal of Materials Research and Technology, Vol 9, Iss 2, Pp 1357-1364 (2020)

This research studies the kinetic transformation and austempering temperature effect on the morphologies of bainite for AISI 6150 steel. A minimum of 10 different holding times for each austempering temperature were utilized. All the AISI 6150 steel

Externí odkaz: https://doaj.org/article/da1f6c376d794378b6ac8e25bc1e9890

Effects of N-terminal acetylation on the aggregation of disease-related α-synuclein variants

Autor: Rosie Bell, Marta Castellana-Cruz, Aishwarya Nene, Rebecca J. Thrush, Catherine K. Xu, Janet R. Kumita, Michele Vendruscolo

Mutations in the SNCA gene, which encodes the protein α-synuclein, have been linked with early onset Parkinson's disease. The exact nature of this association, however, is still poorly understood. To investigate this problem, we started from the obs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b926bd8b18979fb93268c3313fc3041

Tribological behavior of heat treated AISI 6150 steel

Autor: Zhenpu Zhang, Jiayu Hou, Qian Zou, Feng Qiu, Steven J. Thrush, Hong-Yu Yang, Gary C. Barber, Xue Han

Publikováno v: Journal of Materials Research and Technology, Vol 9, Iss 6, Pp 12293-12307 (2020)

This research presents an experimental study on the tribological behavior and plastic deformation layer response of quenched-tempered AISI 6150 steel and austempered AISI 6150 steel under sliding with a ball-on-disk type apparatus. Worn surfaces were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42849a2ef73be0d38817a62846cd20b
https://doi.org/10.1016/j.jmrt.2020.08.089

N-Terminal Acetylation of alpha-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates

Autor: Rosie Bell, Rebecca J. Thrush, Marta Castellana-Cruz, Marc Oeller, Roxine Staats, Aishwarya Nene, Patrick Flagmeier, Catherine K. Xu, Sandeep Satapathy, Celine Galvagnion, Mark R. Wilson, Christopher M. Dobson, Janet R. Kumita, Michele Vendruscolo

Publikováno v: Bell, R, Thrush, R J, Castellana-Cruz, M, Oeller, M, Staats, R, Nene, A, Flagmeier, P, Xu, C K, Satapathy, S, Galvagnion, C, Wilson, M R, Dobson, C M, Kumita, J R & Vendruscolo, M 2022, ' N-Terminal Acetylation of alpha-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates ', Biochemistry, vol. 61, no. 17, pp. 1743–1756 . https://doi.org/10.1021/acs.biochem.2c00104

Parkinson's disease is associated with the aberrant aggregation of alpha-synuclein. Although the causes of this process are still unclear, post-translational modifications of alpha-synuclein are likely to play a modulatory role. Since alpha-synuclein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb437c88f1bc125da79ff32116c790d9
https://curis.ku.dk/ws/files/319248519/acs.biochem.2c00104.pdf