Zobrazeno 1 - 10
of 2 064
pro vyhledávání: '"A. J. Shepherd"'
Autor:
Amit Chandra Das, James M. Nichols, Caitlin V. Crelli, Lu Liu, Riddhi Vichare, Hoang Vu Pham, Caitlyn M. Gaffney, Fisher R. Cherry, Peter M. Grace, Andrew J. Shepherd, Jelena M. Janjic
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract A major and irreversible complication of diabetes is diabetic peripheral neuropathy (DPN), which can lead to significant disability and decreased quality of life. Prior work demonstrates the peptide hormone Angiotensin II (Ang II) is release
Externí odkaz:
https://doaj.org/article/64ead22a811e40809c09ebfdfe02ebad
Autor:
Marwan Awad Ahmed, Helen D. Bailey, Gavin Pereira, Scott W. White, Kingsley Wong, Rhonda Marriott, Matthew J. L. Hare, Bridgette J. McNamara, Carrington C. J. Shepherd
Publikováno v:
BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Australian Aboriginal and Torres Strait Islander women with diabetes in pregnancy (DIP) are more likely to have glycaemic levels above the target range, and their babies are thus at higher risk of excessive fetal growth. Shoulder
Externí odkaz:
https://doaj.org/article/9f31faf0a4314135a8f9cc57e16efde6
Autor:
Junping Jing, Laura Bover, C Ian Mockridge, Kerry L Cox, Mark S Cragg, Tatyana Inzhelevskaya, Chris A Penfold, Vikki English, Jane E Willoughby, Hong Shi, Peter J Morley, Heather Jackson, Roopa Srinivasan, Tom Murray, Axel Hoos, Paul Bojczuk, James Smothers, Niranjan Yanamandra, Lang Dou, Sabyasachi Bhattacharya, Laura Seestaller-Wehr, David Kilian, Kui S Voo, Mel John, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Sara J Brett, Christopher Hopson, Elaine Paul, Stephen L Martin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-
Externí odkaz:
https://doaj.org/article/1d4a1e220c0f453894379600a08cb4a4
Autor:
Lulu Xue, Alex G. Hamilton, Gan Zhao, Zebin Xiao, Rakan El-Mayta, Xuexiang Han, Ningqiang Gong, Xinhong Xiong, Junchao Xu, Christian G. Figueroa-Espada, Sarah J. Shepherd, Alvin J. Mukalel, Mohamad-Gabriel Alameh, Jiaxi Cui, Karin Wang, Andrew E. Vaughan, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lipid nanoparticles for delivering mRNA therapeutics hold immense promise for the treatment of a wide range of lung-associated diseases. However, the lack of effective methodologies capable of identifying the pulmonary delivery profile of ch
Externí odkaz:
https://doaj.org/article/5610f990ab3349ad8170012a73e2cbb4
Publikováno v:
Gastroenterology Research and Practice, Vol 2011 (2011)
Helicobacter pylori infection, often acquired in early childhood, is a global cause of undernutrition, gastritis, peptic ulcer disease and gastric carcinoma. This study tested the feasibility of using H. pylori shed in the faeces as a source of DNA f
Externí odkaz:
https://doaj.org/article/6984bc8512424bffa4b64d5da7aaec41
Autor:
Alexander T. Williams, Jing Chen, Kayesha Coley, Chiara Batini, Abril Izquierdo, Richard Packer, Erik Abner, Stavroula Kanoni, David J. Shepherd, Robert C. Free, Edward J. Hollox, Nigel J. Brunskill, Ioanna Ntalla, Nicola Reeve, Christopher E. Brightling, Laura Venn, Emma Adams, Catherine Bee, Susan E. Wallace, Manish Pareek, Anna L. Hansell, Tõnu Esko, Estonian Biobank Research Team, Daniel Stow, Benjamin M. Jacobs, David A. van Heel, Genes & Health Research Team, William Hennah, Balasubramanya S. Rao, Frank Dudbridge, Louise V. Wain, Nick Shrine, Martin D. Tobin, Catherine John
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake a genome-wide association study of
Externí odkaz:
https://doaj.org/article/e621fa13197b48d594bb390c78b9b2c1
Autor:
Wei Liao, PhD, Meredith Ray, PhD, Carrie Fehnel, BBA, Jordan Goss, MA, Catherine J. Shepherd, MFA, Anita Patel, MHA, Talat Qureshi, BS, Federico Caro, BA, Jessica Roma, AS, Anna Derrick, AA, Anberitha T. Matthews, PhD, Nicholas R. Faris, M. Div, Matthew Smeltzer, PhD, Raymond U. Osarogiagbon, M.B.B.S., FACP
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 2, Pp 100629- (2024)
Introduction: Low-dose computed tomography screening (LDCT) and lung nodule programs (LNP) promote early lung cancer detection, improve survival; Multidisciplinary Care Programs (MDC) promote guideline-concordant care. The impact of such program-base
Externí odkaz:
https://doaj.org/article/001d7cb51e044686839e25f4550701e9
Publikováno v:
PLoS Biology, Vol 21, Iss 10, p e3002348 (2023)
The survival of a population during environmental shifts depends on whether the rate of phenotypic adaptation keeps up with the rate of changing conditions. A common way to achieve this is via change to gene regulatory network (GRN) connections-known
Externí odkaz:
https://doaj.org/article/277106f7dff841ecb93905df4fd9e65e
Autor:
Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M. Billingsley, Rakan El-Mayta, Sarah J. Shepherd, Mohamad-Gabriel Alameh, Drew Weissman, Michael J. Mitchell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Gene delivery to fibroblasts for liver fibrosis treatment remains challenging. Here the authors develop a combinatorial library of ligand-tethered lipidoids via a modular synthetic method and adopt a 2-round screening strategy to identify lipidoids f
Externí odkaz:
https://doaj.org/article/81996ac972bd4186941bbb28373c56ae
Stability of a Simple Bioreactor Model with a General Growth Function, Bacterial Feed and Death Rate
Autor:
Andrew J. Stacey, John J. Shepherd
Publikováno v:
International Journal Bioautomation, Vol 26, Iss 4, Pp 315-324 (2022)
Biological reactors are employed in industrial applications to break down organic waste. Here we consider the stability of an open loop CSTR, with a general growth rate function, having both a bacterial and substrate feed and a death rate. Reactors w
Externí odkaz:
https://doaj.org/article/f7d2047dc2bb420e8b6b02ac3111f3dd