Zobrazeno 1 - 10
of 1 179
pro vyhledávání: '"A. J. Saykin"'
Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation
Autor:
Pradeep Varathan Pugalenthi, Bing He, Linhui Xie, Kwangsik Nho, Andrew J. Saykin, Jingwen Yan
Publikováno v:
BioData Mining, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract Alzheimer’s disease (AD) is a highly heritable brain dementia, along with substantial failure of cognitive function. Large-scale genome-wide association studies (GWASs) have led to a set of SNPs significantly associated with AD and related
Externí odkaz:
https://doaj.org/article/08d95b1169a6436d9516f10b1c912f11
Autor:
Sang‐Won Han, Young Ho Park, Paula J Bice, David A. Bennett, SangYun Kim, Andrew J. Saykin, Kwangsik Nho
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 10, Pp 2799-2804 (2024)
Abstract A synaptic protein, Neuronal Pentraxin 2 (NPTX2), has emerged as a pivotal biomarker for Alzheimer's dementia (AD). We identified candidate miRNAs targeting NPTX2 and performed association and mediation analyses using multi‐omics data (N =
Externí odkaz:
https://doaj.org/article/0de7246f31f447c58a400279cbcd01b2
Autor:
Junhao Wen, Zhijian Yang, Ilya M. Nasrallah, Yuhan Cui, Guray Erus, Dhivya Srinivasan, Ahmed Abdulkadir, Elizabeth Mamourian, Gyujoon Hwang, Ashish Singh, Mark Bergman, Jingxuan Bao, Erdem Varol, Zhen Zhou, Aleix Boquet-Pujadas, Jiong Chen, Arthur W. Toga, Andrew J. Saykin, Timothy J. Hohman, Paul M. Thompson, Sylvia Villeneuve, Randy Gollub, Aristeidis Sotiras, Katharina Wittfeld, Hans J. Grabe, Duygu Tosun, Murat Bilgel, Yang An, Daniel S. Marcus, Pamela LaMontagne, Tammie L. Benzinger, Susan R. Heckbert, Thomas R. Austin, Lenore J. Launer, Mark Espeland, Colin L. Masters, Paul Maruff, Jurgen Fripp, Sterling C. Johnson, John C. Morris, Marilyn S. Albert, R. Nick Bryan, Susan M. Resnick, Luigi Ferrucci, Yong Fan, Mohamad Habes, David Wolk, Li Shen, Haochang Shou, Christos Davatzikos
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alzheimer’s disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain a
Externí odkaz:
https://doaj.org/article/56d631e8319148739bce0f8e8b35d005
Autor:
Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Paula J. Bice, Jared R. Brosch, Rachael Deardorff, Kelley Faber, Martin R. Farlow, Tatiana Foroud, Sujuan Gao, Thea Rosewood, Jun Pyo Kim, Kelly Nudelman, Meichen Yu, Paul Aisen, Reisa Sperling, Basavaraj Hooli, Sergey Shcherbinin, Diana Svaldi, Clifford R. Jack, William J. Jagust, Susan Landau, Aparna Vasanthakumar, Jeffrey F. Waring, Vincent Doré, Simon M. Laws, Colin L. Masters, Tenielle Porter, Christopher C. Rowe, Victor L. Villemagne, Logan Dumitrescu, Timothy J. Hohman, Julia B. Libby, Elizabeth Mormino, Rachel F. Buckley, Keith Johnson, Hyun-Sik Yang, Ronald C. Petersen, Vijay K. Ramanan, Nilüfer Ertekin-Taner, Prashanthi Vemuri, Ann D. Cohen, Kang-Hsien Fan, M. Ilyas Kamboh, Oscar L. Lopez, David A. Bennett, Muhammad Ali, Tammie Benzinger, Carlos Cruchaga, Diana Hobbs, Philip L. De Jager, Masashi Fujita, Vaishnavi Jadhav, Bruce T. Lamb, Andy P. Tsai, Isabel Castanho, Jonathan Mill, Michael W. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI), the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN), the Australian Imaging, Biomarker & Lifestyle Study (AIBL), Andrew J. Saykin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron
Externí odkaz:
https://doaj.org/article/534dba93d5bf4620975ce9a0f564baf7
Autor:
Adam M. Wright, Yu-Chien Wu, Ho-Ching Yang, Shannon L. Risacher, Andrew J. Saykin, Yunjie Tong, Qiuting Wen
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background Cardiac pulsation propels blood through the cerebrovascular network to maintain cerebral homeostasis. The cerebrovascular network is uniquely surrounded by paravascular cerebrospinal fluid (pCSF), which plays a crucial role in was
Externí odkaz:
https://doaj.org/article/dd6915e075624a428a6dd64f508b45b2
Autor:
Özkan İş, Xue Wang, Joseph S. Reddy, Yuhao Min, Elanur Yilmaz, Prabesh Bhattarai, Tulsi Patel, Jeremiah Bergman, Zachary Quicksall, Michael G. Heckman, Frederick Q. Tutor-New, Birsen Can Demirdogen, Launia White, Shunsuke Koga, Vincent Krause, Yasuteru Inoue, Takahisa Kanekiyo, Mehmet Ilyas Cosacak, Nastasia Nelson, Annie J. Lee, Badri Vardarajan, Richard Mayeux, Naomi Kouri, Kaancan Deniz, Troy Carnwath, Stephanie R. Oatman, Laura J. Lewis-Tuffin, Thuy Nguyen, for the Alzheimer’s Disease Neuroimaging Initiative, Minerva M. Carrasquillo, Jonathan Graff-Radford, Ronald C. Petersen, Clifford R. Jr Jack, Kejal Kantarci, Melissa E. Murray, Kwangsik Nho, Andrew J. Saykin, Dennis W. Dickson, Caghan Kizil, Mariet Allen, Nilüfer Ertekin-Taner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular and astrocyte clusters as mai
Externí odkaz:
https://doaj.org/article/0f4d86fabcd9496f8761615d7234bc5b
Publikováno v:
PEC Innovation, Vol 4, Iss , Pp 100282- (2024)
Objectives: Lack of awareness of Alzheimer's disease (AD) among Black Americans may undermine their ability to identify potential AD risk. We examined Black Americans' perceptions and knowledge of AD, and views of a healthy brain, which may contribut
Externí odkaz:
https://doaj.org/article/2ff0866500c148c9845f644733c359b9
Autor:
Sang-Won Han, Jung-Min Pyun, Paula J. Bice, David A. Bennett, Andrew J. Saykin, Sang Yun Kim, Young Ho Park, Kwangsik Nho
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Alzheimer’s dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and machine learning analysis of miRNA can provide insights into AD pathology and prognostic/diagn
Externí odkaz:
https://doaj.org/article/c25ba0ff2be64a3bbeff0c9683d974ff
Autor:
Lauren R. Hirschfeld, Rachael Deardorff, Evgeny J. Chumin, Yu-Chien Wu, Brenna C. McDonald, Sha Cao, Shannon L. Risacher, Dahyun Yi, Min Soo Byun, Jun-Young Lee, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Kwangsik Nho, Andrew J. Saykin, Dong Young Lee, for the KBASE Research Group
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-11 (2023)
Abstract Background White matter (WM) microstructural changes in the hippocampal cingulum bundle (CBH) in Alzheimer’s disease (AD) have been described in cohorts of largely European ancestry but are lacking in other populations. Methods We assessed
Externí odkaz:
https://doaj.org/article/33636f82afb7457ca9b1d0b0072d66f4
Autor:
Zexuan Wang, Qipeng Zhan, Boning Tong, Shu Yang, Bojian Hou, Heng Huang, Andrew J. Saykin, Paul M. Thompson, Christos Davatzikos, Li Shen
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109212- (2024)
Summary: Traditional loss functions such as cross-entropy loss often quantify the penalty for each mis-classified training sample without adequately considering its distance from the ground truth class distribution in the feature space. Intuitively,
Externí odkaz:
https://doaj.org/article/0a287bbe671647cb960f6912d4ffa986