Zobrazeno 1 - 10
of 19
pro vyhledávání: '"A. J. Robert McGray"'
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-29 (2022)
Abstract Oncolytic viruses (OVs) represent a new class of multi-modal immunotherapies for cancer, with OV-elicited antitumor immunity being key to their overall therapeutic efficacy. Currently, the clinical effectiveness of OV as monotherapy remains
Externí odkaz:
https://doaj.org/article/4074a2360a934ab6876fef48c4fe0a6f
Autor:
Emad Y. Alqassim, Shraddha Sharma, A. N. M. Nazmul H. Khan, Tiffany R. Emmons, Eduardo Cortes Gomez, Abdulrahman Alahmari, Kelly L. Singel, Jaron Mark, Bruce A. Davidson, A. J. Robert McGray, Qian Liu, Brian D. Lichty, Kirsten B. Moysich, Jianmin Wang, Kunle Odunsi, Brahm H. Segal, Bora E. Baysal
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing i
Externí odkaz:
https://doaj.org/article/8289df36f80e4288872e7c05d2e770f3
Autor:
A. J. Robert McGray, Ruea-Yea Huang, Sebastiano Battaglia, Cheryl Eppolito, Anthony Miliotto, Kyle B. Stephenson, Amit A. Lugade, Gill Webster, Brian D. Lichty, Mukund Seshadri, Danuta Kozbor, Kunle Odunsi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background Cancer immunotherapies are emerging as promising treatment strategies for ovarian cancer patients that experience disease relapse following first line therapy. As such, identifying strategies to bolster anti-tumor immunity and lim
Externí odkaz:
https://doaj.org/article/80478d4009594eabbb5adee11254fa6a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8742 (2021)
Immunotherapy initially demonstrated promising results in prostate cancer (PCa), but the modest or negative results of many recent trials highlight the need to overcome the poor immunogenicity of this cancer. The design of effective therapies for PCa
Externí odkaz:
https://doaj.org/article/5c344ed9dad34c6c9468f7d4881d3c10
Autor:
Zongjie Wang, Sharif Ahmed, Mahmoud Labib, Hansen Wang, Licun Wu, Fatemeh Bavaghar-Zaeimi, Nastaran Shokri, Soraly Blanco, Saraf Karim, Kasia Czarnecka-Kujawa, Edward H. Sargent, A. J. Robert McGray, Marc de Perrot, Shana O. Kelley
Publikováno v:
Nature Biomedical Engineering.
Autor:
Gregory E, Sokolow, Matthew R, Crawley, Daniel R, Morphet, Didar, Asik, Joseph A, Spernyak, A J Robert, McGray, Timothy R, Cook, Janet R, Morrow
Publikováno v:
Inorg Chem
A metal organic polyhedron (MOP) with four paramagnetic Fe(III) centers was studied as a magnetic resonance imaging (MRI) probe. The MOP was characterized in solution by using EPR and UV-vis spectroscopies, FT-ICR mass spectrometry, and in the solid
Autor:
Brendan Zangari, Takemasa Tsuji, Junko Matsuzaki, Hemn Mohammadpour, Cheryl Eppolito, Sebastiano Battaglia, Fumito Ito, Thinle Chodon, Richard Koya, A. J. Robert McGray, Kunle Odunsi
Publikováno v:
Cancer Immunology, Immunotherapy. 71:2881-2898
Autor:
Gregory E. Sokolow, Matthew R. Crawley, Daniel R. Morphet, Didar Asik, Joseph A. Spernyak, A. J. Robert McGray, Timothy R. Cook, Janet R. Morrow
Publikováno v:
Inorganic Chemistry. 61:2603-2611
Autor:
Kunle Odunsi, Feng Qian, Amit A. Lugade, Han Yu, Melissa A. Geller, Steven P. Fling, Judith C. Kaiser, Andreanne M. Lacroix, Leonard D’Amico, Nirasha Ramchurren, Chihiro Morishima, Mary L. Disis, Lucas Dennis, Patrick Danaher, Sarah Warren, Van Anh Nguyen, Sudharshan Ravi, Takemasa Tsuji, Spencer Rosario, Wenjuan Zha, Alan Hutson, Song Liu, Shashikant Lele, Emese Zsiros, A. J. Robert McGray, Jessie Chiello, Richard Koya, Thinle Chodon, Carl D. Morrison, Vasanta Putluri, Nagireddy Putluri, Donald E. Mager, Rudiyanto Gunawan, Martin A. Cheever, Sebastiano Battaglia, Junko Matsuzaki
Publikováno v:
Sci Transl Med
To uncover underlying mechanisms associated with failure of indoleamine 2,3-dioxygenase 1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical study in 17 patients with newly diagnosed advanced high-grade serous ov
Autor:
Brendan, Zangari, Takemasa, Tsuji, Junko, Matsuzaki, Hemn, Mohammadpour, Cheryl, Eppolito, Sebastiano, Battaglia, Fumito, Ito, Thinle, Chodon, Richard, Koya, A J, Robert McGray, Kunle, Odunsi
Publikováno v:
Cancer immunology, immunotherapy : CII. 71(12)
T-cell longevity is undermined by antigen-driven differentiation programs that render cells prone to attrition through several mechanisms. CD8 Tcf-1 mRNA encoding TCF-1B and TCF-1E isoforms, along with GzmB expression were assessed in CD62L TCF-1B an