Zobrazeno 1 - 10
of 3 805
pro vyhledávání: '"A. J. R. Heck"'
Autor:
Eva Maria Stork, Danique M. H. van Rijswijck, Karin A. van Schie, Max Hoek, Theresa Kissel, Hans Ulrich Scherer, Tom W. J. Huizinga, Albert J. R. Heck, Rene E. M. Toes, Albert Bondt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The presence of autoantibodies is a defining feature of many autoimmune diseases. The number of unique autoantibody clones is conceivably limited by immune tolerance mechanisms, but unknown due to limitations of the currently applied technol
Externí odkaz:
https://doaj.org/article/e6689c79691043a1a6804fa22db7f6ee
Autor:
Isabel Reinisch, Helene Michenthaler, Alba Sulaj, Elisabeth Moyschewitz, Jelena Krstic, Markus Galhuber, Ruonan Xu, Zina Riahi, Tongtong Wang, Nemanja Vujic, Melina Amor, Riccardo Zenezini Chiozzi, Martin Wabitsch, Dagmar Kolb, Anastasia Georgiadi, Lisa Glawitsch, Ellen Heitzer, Tim J. Schulz, Michael Schupp, Wenfei Sun, Hua Dong, Adhideb Ghosh, Anne Hoffmann, Dagmar Kratky, Laura C. Hinte, Ferdinand von Meyenn, Albert J. R. Heck, Matthias Blüher, Stephan Herzig, Christian Wolfrum, Andreas Prokesch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on the regulation of AT immune infiltration is still elusive
Externí odkaz:
https://doaj.org/article/84abdd4dbbbf4fedab68791a6e68856d
Autor:
Remy M. Muts, Maurits A. den Boer, Bart W. Bardoel, Piet C. Aerts, Carla J. C. de Haas, Albert J. R. Heck, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Antibodies play a key role in the immune defence against Gram-negative bacteria. After binding to bacterial surface antigens, IgG and IgM can activate the complement system and trigger formation of lytic membrane attack complex (MAC) pores.
Externí odkaz:
https://doaj.org/article/d8056fd0ab184a219de2c9b130cb1b1f
Autor:
Juan Manuel Valverde, Geronimo Dubra, Michael Phillips, Austin Haider, Carlos Elena-Real, Aurélie Fournet, Emile Alghoul, Dhanvantri Chahar, Nuria Andrés-Sanchez, Matteo Paloni, Pau Bernadó, Guido van Mierlo, Michiel Vermeulen, Henk van den Toorn, Albert J. R. Heck, Angelos Constantinou, Alessandro Barducci, Kingshuk Ghosh, Nathalie Sibille, Puck Knipscheer, Liliana Krasinska, Daniel Fisher, Maarten Altelaar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Cell cycle transitions result from global changes in protein phosphorylation states triggered by cyclin-dependent kinases (CDKs). To understand how this complexity produces an ordered and rapid cellular reorganisation, we generated a high-re
Externí odkaz:
https://doaj.org/article/e9908b9e43c84a22ae719efb78f9bc6b
Autor:
Ying Wang, Carlos F. D. Faurby, Fabian Ruf, Patrik I. Sund, Kasper Nielsen, Nicolas Volet, Martijn J. R. Heck, Nikolai Bart, Andreas D. Wieck, Arne Ludwig, Leonardo Midolo, Stefano Paesani, Peter Lodahl
Publikováno v:
npj Quantum Information, Vol 9, Iss 1, Pp 1-5 (2023)
Abstract We develop a quantum photonic platform that interconnects a high-quality quantum dot single-photon source and a low-loss photonic integrated circuit made in silicon nitride. The platform is characterized and programmed to demonstrate various
Externí odkaz:
https://doaj.org/article/d483a1b37e9a4d56a0b0dc72514790c9
Autor:
Sebastiaan C. de Graaf, Albert Bondt, Danique M. H. van Rijswijck, Hannah G. Juncker, Sien J. Mulleners, Mirjam J. A. Damen, Max Hoek, Britt J. van Keulen, Johannes B. van Goudoever, Albert J. R. Heck, Kelly A. Dingess
Publikováno v:
Frontiers in Nutrition, Vol 10 (2024)
IntroductionUpon vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) humans will start to produce antibodies targeting virus specific antigens that will end up in circulation. In lactating women such antibodies will also
Externí odkaz:
https://doaj.org/article/5e96a5bf2be6463bb05b7f835f7fbe78
Autor:
Dario A. T. Cramer, Vojtech Franc, Anna-Katharina Heidenreich, Michaela Hook, Mahdi Adibzadeh, Dietmar Reusch, Albert J. R. Heck, Markus Haberger
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe development of increasingly complex antibody formats, such as bispecifics, can lead to the formation of increasingly complex high- and low-molecular-weight by-products. Here, we focus on the characterization of high molecular weight speci
Externí odkaz:
https://doaj.org/article/4977507ea3b54d6db73e493e7b387a53
Autor:
Lucas M. P. Chataigner, Christos Gogou, Maurits A. den Boer, Cátia P. Frias, Dominique M. E. Thies-Weesie, Joke C. M. Granneman, Albert J. R. Heck, Dimphna H. Meijer, Bert J. C. Janssen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
In this work the authors show how a combination of glycosylations, rigid and flexible parts within neurofascin 155 and contactin 1 define a 7.4 nm distance at the myelin-axon interface and allow bridging of three-fold larger distances in the synapse.
Externí odkaz:
https://doaj.org/article/513723d5ffb7423c95683e8e1a05d211
Autor:
Danique M. H. van Rijswijck, Albert Bondt, Max Hoek, Karlijn van der Straten, Tom G. Caniels, Meliawati Poniman, Dirk Eggink, Chantal Reusken, Godelieve J. de Bree, Rogier W. Sanders, Marit J. van Gils, Albert J. R. Heck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Profiling antibody repertoires using proteomic approaches may provide a way of screening for antibody cross-reactivity against SARS-CoV-2 variants. Here the authors use a IgG1 specific cleavage method to analyse the IgG1 repertoire within recovered p
Externí odkaz:
https://doaj.org/article/eeaed92f1ab84dfd938e3ee685a8d51e
Autor:
Elyse S. Fischer, Conny W. H. Yu, Johannes F. Hevler, Stephen H. McLaughlin, Sarah L. Maslen, Albert J. R. Heck, Stefan M. V. Freund, David Barford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Formation of the mitotic checkpoint complex (MCC) is catalysed by a phosphorylation-dependent scaffold. This work provides structural details of how a tripartite Mad1:Bub1:Cdc20 complex presents Cdc20 to Mad2, triggering open-to-closed conversion of
Externí odkaz:
https://doaj.org/article/25af90ef4aa84deab038bcc19c9bacc5