Výsledky vyhledávání - "A. J. Pothen"

Interobserver agreement of skeletal muscle mass measurement on head and neck CT imaging at the level of the third cervical vertebra

Autor: Anne W. Wendrich, Ernst J. Smid, Ajit J. Pothen, Justin E. Swartz, Sandra I. Bril, Inge Wegner, R. de Bree, Frank A. Pameijer, G. H. Bol

Publikováno v: European Archives of Oto-Rhino-Laryngology
European Archives of Oto-Rhino-Laryngology, 276(4), 1175. Springer Verlag

Objectives Skeletal muscle mass (SMM) is most often assessed in cancer patients on abdominal computed tomography (CT) imaging at the level of the third lumbar vertebra (L3). Abdominal CT imaging is not routinely performed in head and neck cancer (HNC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69c09bce05bcffeca1b17426e1f5d4d
http://europepmc.org/articles/PMC6426814

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Dissecting the inflammatory twitch in allergically inflamed mice

Autor: Joshua J. Pothen, Jason H. T. Bates, Lennart K. A. Lundblad, Matthew E. Poynter

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 310:L1003-L1009

We have previously advanced the hypothesis that the allergic inflammatory response in the lungs occurs as a self-limited sequence of events that begins with the onset of inflammation and then resolves back to baseline over a predetermined time course

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a180efba065da17c2515988b3b86706c
https://doi.org/10.1152/ajplung.00036.2016

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A Computational Model of Cellular Engraftment on Lung Scaffolds

Autor: Vignesh Rajendran, Bradford J. Smith, Baoshun Ma, Darcy E. Wagner, Jason H. T. Bates, Daniel J. Weiss, Joshua J. Pothen

Publikováno v: BioResearch Open Access, Vol 5, Iss 1, Pp 308-319 (2016)
BioResearch Open Access
Biores. Open Access 5, 308-319 (2016)

The possibility that stem cells might be used to regenerate tissue is now being investigated for a variety of organs, but these investigations are still essentially exploratory and have few predictive tools available to guide experimentation. We prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6d8a04655168f18334e188192fd0c8
https://doi.org/10.1089/biores.2016.0031

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Poor prognosis in human papillomavirus-positive oropharyngeal squamous cell carcinomas that overexpress hypoxia inducible factor-1α

Autor: Inge Stegeman, Ajit J. Pothen, Wilko Grolman, Stefan M. Willems, Fleurieke Karlijn Formsma, Pauline M. W. van Kempen, Ellen M. Van Cann, Justin E. Swartz

Publikováno v: Head & Neck. 38:1338-1346

Background: Hypoxia induces stabilization of the transcription factor HIF-1alpha (HIF-1α), associated with (chemo-)radiotherapy resistance in oropharyngeal squamous cell carcinoma (SCC). We investigated the effect of HIF-1α expression on survival i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::723e92ce220b0d4144f74431339101e5
https://doi.org/10.1002/hed.24445

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Prognostic value of continued smoking on survival and recurrence rates in patients with head and neck cancer: A systematic review

Autor: Inge Wegner, Lieke C R van Imhoff, Gabriëlle G J Kranenburg, Ajit J. Pothen, Sven Macco, Nicoline L Nijman, Wilko Grolman, Elisabeth J van Overbeeke

Publikováno v: Head & Neck. 38:E2214-E2220

BACKGROUND: The purpose of this systematic review was to determine the prognostic value of continued smoking after diagnosis on survival and recurrence rates in head and neck cancer. METHODS: A systematic search was performed and predefined inclusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1bf43d79920c67a2ecd377680b4a25d
https://doi.org/10.1002/hed.24082

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Clinical implications of hypoxia biomarker expression in head and neck squamous cell carcinoma: a systematic review

Autor: Inge Stegeman, Wilko Grolman, Justin E. Swartz, Ajit J. Pothen, Stefan M. Willems

Publikováno v: Cancer Medicine
Cancer Medicine, 4(7), 1101. John Wiley and Sons Ltd

Awareness increases that the tumor biology influences treatment outcome and prognosis in cancer. Tumor hypoxia is thought to decrease sensitivity to radiotherapy and some forms of chemotherapy. Presence of hypoxia may be assessed by investigating exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64acb1725286ca3722dfd4321fd3e892
http://europepmc.org/articles/PMC4529348

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A computational model of unresolved allergic inflammation in chronic asthma

Autor: Matthew E. Poynter, Jason H. T. Bates, Joshua J. Pothen

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 308:L384-L390

We have previously developed an agent-based computational model to demonstrate the feasibility of a novel hypothesis we term the inflammatory twitch. This hypothesis potentially explains the dynamics of the normal response to allergic inflammation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f75fecc9dfefda888af1f2257e7520
https://doi.org/10.1152/ajplung.00268.2014

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Low skeletal muscle mass is a predictive factor for chemotherapy dose-limiting toxicity in patients with locally advanced head and neck cancer

Autor: Ernst J. Smid, Justin E. Swartz, Alexander de Graeff, Remco de Bree, Sandra I. Bril, Anne W. Wendrich, Inge Wegner, Ajit J. Pothen

Publikováno v: Oral Oncology, 71, 26. Elsevier Limited

OBJECTIVES: Low skeletal muscle mass (SMM) or sarcopenia is emerging as an adverse prognostic factor for chemotherapy dose-limiting toxicity (CLDT) and survival in cancer patients. Our aim was to determine the impact of low SMM on CDLT in patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150614f72a3cb4466ac41469f0f70738
https://dspace.library.uu.nl/handle/1874/354730

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Use of the 2-μm continuous wave thulium laser for the resection of oral squamous cell carcinomas does not impair pathological assessment

Autor: Justin E. Swartz, Wilko Grolman, Ajit J. Pothen, Geert J. M. G. van der Heijden, Luuk M. Janssen, Ellen M. Van Cann, Stefan M. Willems, Januska Evenboer

Publikováno v: Lasers in Surgery and Medicine. 46:608-613

Background and Objective Current resection modalities for oral squamous cell carcinomas (OSCC) vary from cold steel over CO2 laser to monopolar electro-surgery (MO). We compared thulium laser (TL) as a new modality with MO with regards to pathologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc236ed70c3f17ee2e1f5e93fb4700d9
https://doi.org/10.1002/lsm.22270

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p16INK4Aand p14ARFGene Promoter Hypermethylation as Prognostic Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma: A Review

Autor: L.W. van Bockel, Ali Al-Kaabi, S. M. Willems, A. J. Pothen

Publikováno v: Disease Markers
Disease Markers, Vol 2014 (2014)

Head and neck squamous cell carcinoma is a heterogeneous group of tumors with each subtype having a distinct histopathological and molecular profile. Most tumors share, to some extent, the same multistep carcinogenic pathways, which include a wide va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408a85efe8ed6e5cbf3f9ff257fc7a63
https://doi.org/10.1155/2014/260549

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