Zobrazeno 1 - 10
of 82
pro vyhledávání: '"A. J. Petris"'
Autor:
Kihoon Nam, Harim Tavares Dos Santos, Frank M. Maslow, Travis Small, Vinit Shanbhag, Michael J. Petris, Olga J. Baker
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24368- (2024)
Radiation therapy is a first-line treatment for head and neck cancer; however, it typically leads to hyposalivation stemming from fibrosis of the salivary gland. Current strategies to restore glandular function are dependent on the presence of residu
Externí odkaz:
https://doaj.org/article/43719b19c2094d53b60256dd4ef040b3
Autor:
Takumi Wagatsuma, Eisuke Suzuki, Miku Shiotsu, Akiko Sogo, Yukina Nishito, Hideya Ando, Hisashi Hashimoto, Michael J. Petris, Masato Kinoshita, Taiho Kambe
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) are essential for pigmentation. They are generally classified as type-3 copper proteins, with binuclear copper active sites. Although there is experimental evidence f
Externí odkaz:
https://doaj.org/article/ba217f3439014ff892ecfb33883a13ee
Autor:
Hille Fieten, Yadvinder Gill, Alan J. Martin, Mafalda Concilli, Karen Dirksen, Frank G. van Steenbeek, Bart Spee, Ted S. G. A. M. van den Ingh, Ellen C. C. P. Martens, Paola Festa, Giancarlo Chesi, Bart van de Sluis, Roderick H. J. H. Houwen, Adrian L. Watson, Yurii S. Aulchenko, Victoria L. Hodgkinson, Sha Zhu, Michael J. Petris, Roman S. Polishchuk, Peter A. J. Leegwater, Jan Rothuizen
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 1, Pp 25-38 (2016)
The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases caused by mutations in the genes coding for the copper transporters ATP7A and ATP7B. Menkes disease, involving ATP7A, is a fatal neurodegenerative disorde
Externí odkaz:
https://doaj.org/article/ed1cab5637da4a468e9d141775e641c2
Autor:
Mohammad Zulkifli, Amy N. Spelbring, Yuteng Zhang, Shivatheja Soma, Si Chen, Luxi Li, Trung Le, Vinit Shanbhag, Michael J. Petris, Tai-Yen Chen, Martina Ralle, David P. Barondeau, Vishal M. Gohil
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Recent studies have uncovered the therapeutic potential of elesclomol (ES), a copper-ionophore, for copper deficiency disorders. However, we currently do not understand the mechanism by which copper brought into cells as ES–Cu(II) is released and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45f336221f47a3e54e268dcee5a5fc59
https://doi.org/10.1073/pnas.2216722120
https://doi.org/10.1073/pnas.2216722120
Publikováno v:
Neurobiology of Disease, Vol 81, Iss , Pp 154-161 (2015)
ATP7A mutations impair copper metabolism resulting in three distinct genetic disorders in humans. These diseases are characterized by neurological phenotypes ranging from intellectual disability to neurodegeneration. Severe ATP7A loss-of-function all
Externí odkaz:
https://doaj.org/article/0942e2c9bf204861b1f7dfa36e4b29a3
Autor:
Christopher J. Hlynialuk, Binbing Ling, Zakery N. Baker, Paul A. Cobine, Lisa D. Yu, Aren Boulet, Timothy Wai, Amzad Hossain, Amr M. El Zawily, Pamela J. McFie, Scot J. Stone, Francisca Diaz, Carlos T. Moraes, Deepa Viswanathan, Michael J. Petris, Scot C. Leary
Publikováno v:
Cell Reports, Vol 10, Iss 6, Pp 933-943 (2015)
Human SCO1 fulfills essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper (Cu) homeostasis, yet it remains unclear why pathogenic mutations in this gene cause such clinically heterogeneous forms of disease. Here, we esta
Externí odkaz:
https://doaj.org/article/0340b7e99d004b629b58872104cbc6a2
Autor:
Hannah Faith Greene, Byung-Eun Kim, Michael J. Petris, Mohammad Zulkifli, Liam M. Guthrie, James C. Sacchettini, Elyssa Nunez, Thomas Snavely, Arjun Acharya, Andres Silva, Vishal M. Gohil, Brogan Lynch, Vinit Shanbhag, Sai Yuan, Franklin R. Lopez, Shivatheja Soma, Courtney De Ville
Publikováno v:
Science
Elesclomol rescues Menkes disease mice Menkes disease results from loss-of-function mutations in the P-type copper-transporting adenosine triphosphatase ATP7A. Children diagnosed with Menkes present with connective tissue abnormalities and neurodegen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8e07eb8a2db245d605c596bc6aa201
https://doi.org/10.1126/science.aaz8899
https://doi.org/10.1126/science.aaz8899
Autor:
Michael J. Petris, Michael L. Schilsky, Justin R. Cross, Q Ping Dou, Gina M. DeNicola, Ashley I. Bush, Peng Yuan, Roman S. Polishchuk, Sanjeev Gupta, Donita C. Brady, Stephen G. Kaler, Katherine J. Franz, Vishal M. Gohil, Nicholas K. Tonks, Vivek Mittal, Svetlana Lutsenko, Linda Van Aelst, Eva J Ge, Dan Xi, Martina Ralle, Angela Casini, Christopher J. Chang, Linda T. Vahdat, Paul A. Cobine
Publikováno v:
Nat Rev Cancer
Nature Reviews Cancer, vol 22, iss 2
Nature Reviews Cancer, vol 22, iss 2
Copper is an essential nutrient whose redox properties make it both beneficial and toxic to the cell. Recent progress in studying transition metal signalling has forged new links between researchers of different disciplines that can help translate ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5164f6aef86627fe77e70977f340f74
https://pubmed.ncbi.nlm.nih.gov/34764459
https://pubmed.ncbi.nlm.nih.gov/34764459
Autor:
Lucas T Woods, Jean M Camden, Farid G El-Sayed, Mahmoud G Khalafalla, Michael J Petris, Laurie Erb, Gary A Weisman
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0123641 (2015)
Transforming growth factor-β (TGF-β) is a multi-functional cytokine with a well-described role in the regulation of tissue fibrosis and regeneration in the liver, kidney and lung. Submandibular gland (SMG) duct ligation and subsequent deligation in
Externí odkaz:
https://doaj.org/article/ef6716bf45674d6489c3c78a66c7d69e
Autor:
Ying Zhao, Kui Li, Chunwei Cao, Xiaojuan Liang, Jianguo Zhao, Michael J. Petris, Yajun Wang, Cong Tao, Jianfei Pan, Yiping Fan, Yanfang Wang
Publikováno v:
Diabetologia. 62:2340-2353
ATPase copper transporting α (ATP7A), also known as Menkes disease protein, is a P-type ATPase that transports copper across cell membranes. The critical role of ATP7A-mediated copper homeostasis has been well recognised in various organs, such as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a59cb3577494cb55d46b4191deb207b
https://doi.org/10.1007/s00125-019-4966-2
https://doi.org/10.1007/s00125-019-4966-2