Zobrazeno 1 - 10
of 21
pro vyhledávání: '"A. J. P. De Haas"'
Autor:
Sjors P. A. van der Lans, Bart W. Bardoel, Maartje Ruyken, Carla J. C. de Haas, Stan Baijens, Remy M. Muts, Lisette M. Scheepmaker, Piet C. Aerts, Marije F. L. van ’t Wout, Johannes Preiner, Renoud J. Marijnissen, Janine Schuurman, Frank J. Beurskens, Priscilla F. Kerkman, Suzan H. M. Rooijakkers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Antibody-dependent complement activation plays a key role in the natural human immune response to infections. Currently, the understanding of which antibody-antigen combinations drive a potent complement response on bacteria is limited. Here
Externí odkaz:
https://doaj.org/article/a558f4acbc8844f0b4f524c388b29ef9
Autor:
Frerich M. Masson, Salvör Káradóttir, Sjors P. A. van der Lans, Dennis J. Doorduijn, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Bart W. Bardoel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part of our innate immune resp
Externí odkaz:
https://doaj.org/article/95f5d01250314a67b82131f20bab09f7
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011262 (2024)
Engineered gene-drive techniques for population modification and/or suppression have the potential for tackling complex challenges, including reducing the spread of diseases and invasive species. Gene-drive systems with low threshold frequencies for
Externí odkaz:
https://doaj.org/article/51149145c9134ed7a0d57273d4e7497f
Autor:
Remy M. Muts, Maurits A. den Boer, Bart W. Bardoel, Piet C. Aerts, Carla J. C. de Haas, Albert J. R. Heck, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Antibodies play a key role in the immune defence against Gram-negative bacteria. After binding to bacterial surface antigens, IgG and IgM can activate the complement system and trigger formation of lytic membrane attack complex (MAC) pores.
Externí odkaz:
https://doaj.org/article/d8056fd0ab184a219de2c9b130cb1b1f
Autor:
Josefien W. Hommes, Rachel M. Kratofil, Sigrid Wahlen, Carla J. C. de Haas, Reeni B. Hildebrand, G. Kees Hovingh, Micheal Otto, Miranda van Eck, Menno Hoekstra, Suzanne J. A. Korporaal, Bas G. J. Surewaard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Staphylococcus aureus virulence has been associated with the production of phenol-soluble modulins (PSMs). These PSMs have distinct virulence functions and are known to activate, attract and lyse neutrophils. These PSM-associated biological
Externí odkaz:
https://doaj.org/article/d79e59c52eb7439aaa4c53dd098bcdb8
Autor:
Lisanne de Vor, Coco R. Beudeker, Anne Flier, Lisette M. Scheepmaker, Piet C. Aerts, Daniel C. Vijlbrief, Mireille N. Bekker, Frank J. Beurskens, Kok P. M. van Kessel, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Michiel van der Flier
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Central line associated bloodstream infections (CLABSI) with Staphylococcus epidermidis are a major cause of morbidity in neonates, who have an increased risk of infection because of their immature immune system. As especially preterm neonates suffer
Externí odkaz:
https://doaj.org/article/c668e35acaa743bdbfdce9f1042fa215
Autor:
Dennis J. Doorduijn, Dani A. C. Heesterbeek, Maartje Ruyken, Carla J. C. de Haas, Daphne A. C. Stapels, Piet C. Aerts, Suzan H. M. Rooijakkers, Bart W. Bardoel
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monome
Externí odkaz:
https://doaj.org/article/dfe85b977e9f41b49d59a18f8b19cb34
Autor:
Angelino T. Tromp, Yuxi Zhao, Ilse Jongerius, Erik C. J. M. Heezius, Pauline Abrial, Maartje Ruyken, Jos A. G. van Strijp, Carla J. C. de Haas, András N. Spaan, Kok P. M. van Kessel, Thomas Henry, Pieter-Jan A. Haas
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
Bacterial pathogens have evolved to secrete strong anti-inflammatory proteins that target the immune system. It was long speculated whether these virulence factors could serve as therapeutics in diseases in which abnormal immune activation plays a ro
Externí odkaz:
https://doaj.org/article/884250d0a4b64443b263765e26fc16a7
Autor:
Kirsten J. Koymans, Louris J. Feitsma, Adinda Bisschop, Eric G. Huizinga, Jos A. G. van Strijp, Carla J. C. de Haas, Alex J. McCarthy
Publikováno v:
Veterinary Research, Vol 49, Iss 1, Pp 1-15 (2018)
Abstract Staphylococcus aureus is a versatile opportunistic pathogen, causing disease in human and animal species. Its pathogenicity is linked to the ability of S. aureus to secrete immunomodulatory molecules. These evasion proteins bind to host rece
Externí odkaz:
https://doaj.org/article/723fcc61862743068c460d6d94a1a63a
Autor:
Eija Nissilä, Pipsa Hakala, Katarzyna Leskinen, Angela Roig, Shahan Syed, Kok P. M. Van Kessel, Jari Metso, Carla J. C. De Haas, Päivi Saavalainen, Seppo Meri, Angeliki Chroni, Jos A. G. Van Strijp, Katariina Öörni, Matti Jauhiainen, T. Sakari Jokiranta, Karita Haapasalo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma. Although
Externí odkaz:
https://doaj.org/article/50fa5f1b73774b2ebc5f09103838760f