Zobrazeno 1 - 10
of 214
pro vyhledávání: '"A. J. Mileto"'
Autor:
Milena M. Awad, Chathura D. Suraweera, Callum J. Vidor, Auberon Y. Ye-Lin, Galain C. Williams, Steven J. Mileto, Christopher K. Barlow, Sheena McGowan, Dena Lyras
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The Clostridia produce and secrete Large Clostridial Glucosylating Toxins (LCGTs) responsible for disease symptoms, but the secretion mechanism is largely unknown. Recently, a holin-like protein was shown to be essential for toxin secretion.
Externí odkaz:
https://doaj.org/article/4a446196e3d143f6a77c4fab0b7aaa47
Autor:
Steven J. Mileto, Melanie L. Hutton, Sarah L. Walton, Antariksh Das, Lisa J. Ioannidis, Don Ketagoda, Kylie M. Quinn, Kate M. Denton, Diana S. Hansen, Dena Lyras
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Clostridioides difficile is the most common cause of infectious antibiotic-associated diarrhea, with disease mediated by two major toxins TcdA and TcdB. In severe cases, systemic disease complications may arise, resulting in fatal disease. Systemic d
Externí odkaz:
https://doaj.org/article/aa191c606e3d4d01907ecf57b6745d17
Autor:
Avinash V. Karpe, Melanie L. Hutton, Steven J. Mileto, Meagan L. James, Chris Evans, Amol B. Ghodke, Rohan M. Shah, Suzanne S. Metcalfe, Jian-Wei Liu, Tom Walsh, Dena Lyras, Enzo A. Palombo, David J. Beale
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1636 (2023)
Apicomplexan infections, such as giardiasis and cryptosporidiosis, negatively impact a considerable proportion of human and commercial livestock populations. Despite this, the molecular mechanisms of disease, particularly the effect on the body beyon
Externí odkaz:
https://doaj.org/article/db84e36e524e4318a1a1bca1dd82130f
Publikováno v:
Nature Reviews Microbiology. 21:260-274
Autor:
Sarah E. Lucas, Sarah L. Walton, Katrina M. Mirabito Colafella, Steven J. Mileto, Dena Lyras, Kate M. Denton
Publikováno v:
Hypertension.
Gut dysfunction has emerged as a contributor to hypertension, the leading risk factor for disease globally, including stroke, heart failure, and kidney disease. This is underpinned by breakdown of the homeostatic relationship connecting intestinal ep
Autor:
Avinash V. Karpe, Melanie L. Hutton, Steven J. Mileto, Meagan L. James, Chris Evans, Rohan M. Shah, Amol B. Ghodke, Katie E. Hillyer, Suzanne S. Metcalfe, Jian-Wei Liu, Tom Walsh, Dena Lyras, Enzo A. Palombo, David J. Beale
Publikováno v:
Metabolites, Vol 11, Iss 6, p 380 (2021)
Cryptosporidiosis is a major human health concern globally. Despite well-established methods, misdiagnosis remains common. Our understanding of the cryptosporidiosis biochemical mechanism remains limited, compounding the difficulty of clinical diagno
Externí odkaz:
https://doaj.org/article/d440e1d4863b4a40a4b7ac06b4d87df7
Autor:
Avinash V Karpe, Melanie L Hutton, Steven J Mileto, Meagan L James, Chris Evans, Amol B Ghodke, Rohan M Shah, Suzanne S Metcalfe, Jian-Wei Liu, Tom Walsh, Dena Lyras, Enzo A Palombo, David J Beale
Apicomplexan infections, such as giardiasis and cryptosporidiosis, negatively impact a considerable proportion of human and commercial livestock populations. Despite this, the molecular mecha-nisms of disease, particularly the effect on the body beyo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6357e19d44da886e219df11ea927821c
https://doi.org/10.20944/preprints202212.0094.v1
https://doi.org/10.20944/preprints202212.0094.v1
Publikováno v:
The Guthrie Journal. 74
Background Buprenorphine is a synthetic opioid frequently used in combination with naloxone for the treatment of opioid use disorder (OUD). Overall buprenorphine distribution has increased nationally; however, pronounced regional differences in this
BackgroundBuprenorphine is a synthetic opioid frequently used in combination with naloxone for the treatment of opioid use disorder (OUD). Overall buprenorphine distribution has increased nationally; however, pronounced regional differences in this d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9a2c5f643e81f8578f52c4a7416d956
https://doi.org/10.1101/2022.07.01.22277139
https://doi.org/10.1101/2022.07.01.22277139
Autor:
Dena Lyras, John A. Shupe, Jaime L. Jensen, Michael J Sheedlo, Ashleigh P. Rogers, Sarah C. Bloch, Steven J. Mileto, Melanie L. Hutton, Simon Wilkins, Kevin O. Childress, Genevieve Kerr, D. Borden Lacy, Rebekah Engel, Paul J. McMurrick, Thierry Jarde, Katja Horvay, Tracey J. Flores, Helen E. Abud
Publikováno v:
Proc Natl Acad Sci U S A
Gastrointestinal infections often induce epithelial damage that must be repaired for optimal gut function. While intestinal stem cells are critical for this regeneration process [R. C. van der Wath, B. S. Gardiner, A. W. Burgess, D. W. Smith, PLoS On