Výsledky vyhledávání - "A. J. Krentz"

Akademický článek

PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Abstract The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta cell formation but its role on human beta cell deve

Externí odkaz: https://doaj.org/article/04c9903c45a041a292092f38195e3bde

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Akademický článek

A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

Autor: Daipayan Banerjee, Kurt Langberg, Salar Abbas, Eric Odermatt, Praveen Yerramothu, Martin Volaric, Matthew A. Reidenbach, Kathy J. Krentz, C. Dustin Rubinstein, David L. Brautigan, Tarek Abbas, Bradley D. Gelfand, Jayakrishna Ambati, Nagaraj Kerur

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated rep

Externí odkaz: https://doaj.org/article/369050a7118f414592da44c95861d278

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Akademický článek

Assessment of Mosaicism and Detection of Cryptic Alleles in CRISPR/Cas9-Engineered Neurofibromatosis Type 1 and TP53 Mutant Porcine Models Reveals Overlooked Challenges in Precision Modeling of Human Diseases

Autor: Clifford Dustin Rubinstein, Dalton T. McLean, Brent P. Lehman, Jennifer J. Meudt, Dominic T. Schomberg, Kathy J. Krentz, Jamie L. Reichert, Mark B. Meyer, Marie Adams, Charles M. Konsitzke, Dhanansayan Shanmuganayagam

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Genome editing in pigs has been made efficient, practical, and economically viable by the CRISPR/Cas9 platform, representing a promising new era in translational modeling of human disease for research and preclinical development of therapies and devi

Externí odkaz: https://doaj.org/article/c901f93349584b52870a52843c992889

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Akademický článek

Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries.

Autor: Anqi Fu, Sydney M Oberholtzer, Stefan Bagheri-Fam, Raphael H Rastetter, Claire Holdreith, Valeria L Caceres, Steven V John, Sarah A Shaw, Kathleen J Krentz, Xiaoyun Zhang, Chi-Chung Hui, Dagmar Wilhelm, Joan S Jorgensen

Publikováno v: PLoS Genetics, Vol 14, Iss 8, p e1007488 (2018)

Women and other mammalian females are born with a finite supply of oocytes that determine their reproductive lifespan. During fetal development, individual oocytes are enclosed by a protective layer of granulosa cells to form primordial follicles tha

Externí odkaz: https://doaj.org/article/10d4f1998aaa4d66826613474a5d568e

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Evolution of Type 2 Diabetes Management from a Glucocentric Approach to Cardio-Renal Risk Reduction: The New Paradigm of Care

Autor: Stephan Jacob, John E. Deanfield, Andrew J. Krentz, Lars Rydén

Publikováno v: Drugs. 81:1373-1379

For many years, clinical studies could not show that lowering glucose in patients with type 2 diabetes leads to better macrovascular outcomes. In the past few years, new data have shown that treatment with two classes of dugs developed as "glucose-lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f21d4bb433d80208547bf6cc4db635b
https://doi.org/10.1007/s40265-021-01554-6

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Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

Autor: Tamadher A. Alghamdi, Nicole A. J. Krentz, Nancy Smith, Aliya F. Spigelman, Varsha Rajesh, Alok Jha, Mourad Ferdaoussi, Jocelyn E Manning Fox, Han Sun, Zijie Sun, Anna L. Gloyn, Patrick E. MacDonald

Genome-wide association studies have identified hundreds of signals for type 2 diabetes (T2D), most of which confer risk through effects on gene expression. We previously identified the transcription factor ZMIZ1 as a probable effector transcript in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::295d231f94f5a18823e340251aa8e8d8
https://doi.org/10.1101/2022.05.18.492530

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